Innate Immune Sensors and Cell Death—Frontiers Coordinating Homeostasis, Immunity, and Inflammation in Skin
The skin provides a life-sustaining interface between the body and the external environment. A dynamic communication among immune and non-immune cells in the skin is essential to ensure body homeostasis. Dysregulated cellular communication can lead to the manifestation of inflammatory skin condition...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-02-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/17/2/241 |
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| author | Ye Mon Soe Seen Ling Sim Snehlata Kumari |
| author_facet | Ye Mon Soe Seen Ling Sim Snehlata Kumari |
| author_sort | Ye Mon Soe |
| collection | DOAJ |
| description | The skin provides a life-sustaining interface between the body and the external environment. A dynamic communication among immune and non-immune cells in the skin is essential to ensure body homeostasis. Dysregulated cellular communication can lead to the manifestation of inflammatory skin conditions. In this review, we will focus on the following two key frontiers in the skin: innate immune sensors and cell death, as well as their cellular crosstalk in the context of skin homeostasis and inflammation. This review will highlight the recent advancements and mechanisms of how these pathways integrate signals and orchestrate skin immunity, focusing on inflammatory skin diseases and skin infections in mice and humans. |
| format | Article |
| id | doaj-art-4fb153eda70b45d78a7591f90ee5f1a8 |
| institution | OA Journals |
| issn | 1999-4915 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj-art-4fb153eda70b45d78a7591f90ee5f1a82025-08-20T02:03:32ZengMDPI AGViruses1999-49152025-02-0117224110.3390/v17020241Innate Immune Sensors and Cell Death—Frontiers Coordinating Homeostasis, Immunity, and Inflammation in SkinYe Mon Soe0Seen Ling Sim1Snehlata Kumari2Frazer Institute, The University of Queensland, Dermatology Research Centre, Woolloongabba, Brisbane, QLD 4102, AustraliaFrazer Institute, The University of Queensland, Dermatology Research Centre, Woolloongabba, Brisbane, QLD 4102, AustraliaFrazer Institute, The University of Queensland, Dermatology Research Centre, Woolloongabba, Brisbane, QLD 4102, AustraliaThe skin provides a life-sustaining interface between the body and the external environment. A dynamic communication among immune and non-immune cells in the skin is essential to ensure body homeostasis. Dysregulated cellular communication can lead to the manifestation of inflammatory skin conditions. In this review, we will focus on the following two key frontiers in the skin: innate immune sensors and cell death, as well as their cellular crosstalk in the context of skin homeostasis and inflammation. This review will highlight the recent advancements and mechanisms of how these pathways integrate signals and orchestrate skin immunity, focusing on inflammatory skin diseases and skin infections in mice and humans.https://www.mdpi.com/1999-4915/17/2/241skin homeostasisinnate immune sensorsprogrammed cell deathapoptosisnecroptosispyroptosis |
| spellingShingle | Ye Mon Soe Seen Ling Sim Snehlata Kumari Innate Immune Sensors and Cell Death—Frontiers Coordinating Homeostasis, Immunity, and Inflammation in Skin Viruses skin homeostasis innate immune sensors programmed cell death apoptosis necroptosis pyroptosis |
| title | Innate Immune Sensors and Cell Death—Frontiers Coordinating Homeostasis, Immunity, and Inflammation in Skin |
| title_full | Innate Immune Sensors and Cell Death—Frontiers Coordinating Homeostasis, Immunity, and Inflammation in Skin |
| title_fullStr | Innate Immune Sensors and Cell Death—Frontiers Coordinating Homeostasis, Immunity, and Inflammation in Skin |
| title_full_unstemmed | Innate Immune Sensors and Cell Death—Frontiers Coordinating Homeostasis, Immunity, and Inflammation in Skin |
| title_short | Innate Immune Sensors and Cell Death—Frontiers Coordinating Homeostasis, Immunity, and Inflammation in Skin |
| title_sort | innate immune sensors and cell death frontiers coordinating homeostasis immunity and inflammation in skin |
| topic | skin homeostasis innate immune sensors programmed cell death apoptosis necroptosis pyroptosis |
| url | https://www.mdpi.com/1999-4915/17/2/241 |
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