Role of plasma neuropeptide Y in acute myocardial infarction: a case-control study
Abstract Background As neuropeptide Y is associated with endothelial dysfunction, this study explored the relationship between neuropeptide Y and acute myocardial infarction. Methods We included 128 acute myocardial infarction cases and 62 controls. Using the SYNTAX scoring system, the acute myocard...
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BMC
2024-11-01
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| Series: | BMC Cardiovascular Disorders |
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| Online Access: | https://doi.org/10.1186/s12872-024-04373-1 |
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| author | Yan-li Zheng Hui-li Lin Yue-ting Li Mei-mei Li Jing-ru Du Wan-da Wang Yao-guo Wang Yin-lian Cai |
| author_facet | Yan-li Zheng Hui-li Lin Yue-ting Li Mei-mei Li Jing-ru Du Wan-da Wang Yao-guo Wang Yin-lian Cai |
| author_sort | Yan-li Zheng |
| collection | DOAJ |
| description | Abstract Background As neuropeptide Y is associated with endothelial dysfunction, this study explored the relationship between neuropeptide Y and acute myocardial infarction. Methods We included 128 acute myocardial infarction cases and 62 controls. Using the SYNTAX scoring system, the acute myocardial infarction group was sub-grouped into “SYNTAX ≤ 22,” “SYNTAX = 23–32,” and “SYNTAX ≥ 33.” Plasma neuropeptide Y, endothelin, endothelial nitric oxide synthase, and thromboxane A2 levels were measured. Results The acute myocardial infarction group had higher plasma neuropeptide Y, endothelin, and thromboxane A2 levels than controls ([58.76 ± 17.63 vs. 37.48 ± 11.36 ng/ml, P = 0.000], [36.16 ± 10.04 vs. 27.80 ± 7.18 pg/ml, P = 0.000], and [27.69 ± 6.91 vs. 24.32 ± 7.28 pg/ml, P = 0.002], respectively). The acute myocardial infarction group also had lower plasma endothelial nitric oxide synthase levels than controls (3.00 ± 0.94 vs. 4.05 ± 1.44 ng/ml, P = 0.000). Additionally, the receiver operating characteristic curve analysis showed that a neuropeptide Y value of 49.94 ng/ml could help diagnose acute myocardial infarction (sensitivity: 70.9%; specificity: 91.9%). The SYNTAX scores, smoking, plasma endothelin, thromboxane A2, and neuropeptide Y levels were positively correlated, whereas plasma endothelial nitric oxide synthase and neuropeptide Y levels were negatively correlated. Lastly, plasma neuropeptide Y levels were different among subgroups (P < 0.05); patients with higher SYNTAX scores had higher neuropeptide Y levels. Conclusions The levels of plasma NPY may be accociated with the AMI process. |
| format | Article |
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| institution | DOAJ |
| issn | 1471-2261 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj-art-4fb093fced4a4eae93eba7f3f35986932025-08-20T02:51:45ZengBMCBMC Cardiovascular Disorders1471-22612024-11-012411910.1186/s12872-024-04373-1Role of plasma neuropeptide Y in acute myocardial infarction: a case-control studyYan-li Zheng0Hui-li Lin1Yue-ting Li2Mei-mei Li3Jing-ru Du4Wan-da Wang5Yao-guo Wang6Yin-lian Cai7Department of Cardiology, The Second Affiliated Hospital of Fujian Medical UniversityDepartment of Cardiology, The Second Affiliated Hospital of Fujian Medical University Department of Nephrology, The Second Affiliated Hospital of Fujian Medical UniversityDepartment of Cardiology, The Second Affiliated Hospital of Fujian Medical UniversityDepartment of Cardiology, The Second Affiliated Hospital of Fujian Medical UniversityDepartment of Cardiology, The Second Affiliated Hospital of Fujian Medical UniversityDepartment of Cardiology, The Second Affiliated Hospital of Fujian Medical UniversityDepartment of Cardiology, The Second Affiliated Hospital of Fujian Medical UniversityAbstract Background As neuropeptide Y is associated with endothelial dysfunction, this study explored the relationship between neuropeptide Y and acute myocardial infarction. Methods We included 128 acute myocardial infarction cases and 62 controls. Using the SYNTAX scoring system, the acute myocardial infarction group was sub-grouped into “SYNTAX ≤ 22,” “SYNTAX = 23–32,” and “SYNTAX ≥ 33.” Plasma neuropeptide Y, endothelin, endothelial nitric oxide synthase, and thromboxane A2 levels were measured. Results The acute myocardial infarction group had higher plasma neuropeptide Y, endothelin, and thromboxane A2 levels than controls ([58.76 ± 17.63 vs. 37.48 ± 11.36 ng/ml, P = 0.000], [36.16 ± 10.04 vs. 27.80 ± 7.18 pg/ml, P = 0.000], and [27.69 ± 6.91 vs. 24.32 ± 7.28 pg/ml, P = 0.002], respectively). The acute myocardial infarction group also had lower plasma endothelial nitric oxide synthase levels than controls (3.00 ± 0.94 vs. 4.05 ± 1.44 ng/ml, P = 0.000). Additionally, the receiver operating characteristic curve analysis showed that a neuropeptide Y value of 49.94 ng/ml could help diagnose acute myocardial infarction (sensitivity: 70.9%; specificity: 91.9%). The SYNTAX scores, smoking, plasma endothelin, thromboxane A2, and neuropeptide Y levels were positively correlated, whereas plasma endothelial nitric oxide synthase and neuropeptide Y levels were negatively correlated. Lastly, plasma neuropeptide Y levels were different among subgroups (P < 0.05); patients with higher SYNTAX scores had higher neuropeptide Y levels. Conclusions The levels of plasma NPY may be accociated with the AMI process.https://doi.org/10.1186/s12872-024-04373-1Acute myocardial infarctionEndothelial functionNeuropeptide Y |
| spellingShingle | Yan-li Zheng Hui-li Lin Yue-ting Li Mei-mei Li Jing-ru Du Wan-da Wang Yao-guo Wang Yin-lian Cai Role of plasma neuropeptide Y in acute myocardial infarction: a case-control study BMC Cardiovascular Disorders Acute myocardial infarction Endothelial function Neuropeptide Y |
| title | Role of plasma neuropeptide Y in acute myocardial infarction: a case-control study |
| title_full | Role of plasma neuropeptide Y in acute myocardial infarction: a case-control study |
| title_fullStr | Role of plasma neuropeptide Y in acute myocardial infarction: a case-control study |
| title_full_unstemmed | Role of plasma neuropeptide Y in acute myocardial infarction: a case-control study |
| title_short | Role of plasma neuropeptide Y in acute myocardial infarction: a case-control study |
| title_sort | role of plasma neuropeptide y in acute myocardial infarction a case control study |
| topic | Acute myocardial infarction Endothelial function Neuropeptide Y |
| url | https://doi.org/10.1186/s12872-024-04373-1 |
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