Spectroscopic Investigation of Chlorin-Based Photosensitizers in Polymer Matrix
Chlorin e6 and its derivatives are the basis of a number of drugs used in medicine in the treatment of various diseases, including cancer, by photodynamic therapy. Nonpolar derivatives of Chlorin e6—dimethyl ether of Chlorin e6 (DME Ce6) and trimethyl ether of Chlorin e6 (TME Ce6)—are actively studi...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | International Journal of Polymer Science |
| Online Access: | http://dx.doi.org/10.1155/2021/8842052 |
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| _version_ | 1850224437183381504 |
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| author | Antonina Naumenko Nataliya Kutsevol |
| author_facet | Antonina Naumenko Nataliya Kutsevol |
| author_sort | Antonina Naumenko |
| collection | DOAJ |
| description | Chlorin e6 and its derivatives are the basis of a number of drugs used in medicine in the treatment of various diseases, including cancer, by photodynamic therapy. Nonpolar derivatives of Chlorin e6—dimethyl ether of Chlorin e6 (DME Ce6) and trimethyl ether of Chlorin e6 (TME Ce6)—are actively studied for application during photodynamic therapy. In this work, based on the electron optical absorption spectra, the interaction of photosensitizer molecules with branched star-like copolymer dextran-graft-polyacrylamide in anionic form was investigated and the possibility of using the latter as a carrier for drug delivery to tumor cells was suggested. |
| format | Article |
| id | doaj-art-4fae9db8592c4334b00f2c1d03f0fd56 |
| institution | OA Journals |
| issn | 1687-9422 1687-9430 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Polymer Science |
| spelling | doaj-art-4fae9db8592c4334b00f2c1d03f0fd562025-08-20T02:05:37ZengWileyInternational Journal of Polymer Science1687-94221687-94302021-01-01202110.1155/2021/88420528842052Spectroscopic Investigation of Chlorin-Based Photosensitizers in Polymer MatrixAntonina Naumenko0Nataliya Kutsevol1Faculty of Physics, Taras Shevchenko National University of Kyiv, Kyiv, 01601, UkraineFaculty of Chemistry, Taras Shevchenko National University of Kyiv, Kyiv, 01601, UkraineChlorin e6 and its derivatives are the basis of a number of drugs used in medicine in the treatment of various diseases, including cancer, by photodynamic therapy. Nonpolar derivatives of Chlorin e6—dimethyl ether of Chlorin e6 (DME Ce6) and trimethyl ether of Chlorin e6 (TME Ce6)—are actively studied for application during photodynamic therapy. In this work, based on the electron optical absorption spectra, the interaction of photosensitizer molecules with branched star-like copolymer dextran-graft-polyacrylamide in anionic form was investigated and the possibility of using the latter as a carrier for drug delivery to tumor cells was suggested.http://dx.doi.org/10.1155/2021/8842052 |
| spellingShingle | Antonina Naumenko Nataliya Kutsevol Spectroscopic Investigation of Chlorin-Based Photosensitizers in Polymer Matrix International Journal of Polymer Science |
| title | Spectroscopic Investigation of Chlorin-Based Photosensitizers in Polymer Matrix |
| title_full | Spectroscopic Investigation of Chlorin-Based Photosensitizers in Polymer Matrix |
| title_fullStr | Spectroscopic Investigation of Chlorin-Based Photosensitizers in Polymer Matrix |
| title_full_unstemmed | Spectroscopic Investigation of Chlorin-Based Photosensitizers in Polymer Matrix |
| title_short | Spectroscopic Investigation of Chlorin-Based Photosensitizers in Polymer Matrix |
| title_sort | spectroscopic investigation of chlorin based photosensitizers in polymer matrix |
| url | http://dx.doi.org/10.1155/2021/8842052 |
| work_keys_str_mv | AT antoninanaumenko spectroscopicinvestigationofchlorinbasedphotosensitizersinpolymermatrix AT nataliyakutsevol spectroscopicinvestigationofchlorinbasedphotosensitizersinpolymermatrix |