Woxuanzhongzhou formula improves DHEAS and high-fat diet-induced IR and anovulatory mice via AMPK/PGC1- α/Irisin pathway

Woxuanzhongzhou formula improves DHEAS and high-fat diet-induced IR and anovulatory mice via AMPK/PGC1- α/Irisin pathway

Abstract Background Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder in women of reproductive age. Anovulation is one of the most important clinical features of PCOS, and insulin resistance (IR) is one of the critical pathogenic factors. Woxuanzhongzhou (WXZZ) is a tradi...

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Bibliographic Details
Main Authors: Haijuan Liu, Guohua Wang, Conglu Sui, Yanan Guo, Xiangyu He
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Journal of Ovarian Research
Subjects:
Polycystic ovary syndrome
Insulin resistance
Irisin
FNDC5
AMPK
PGC1-α
Online Access:https://doi.org/10.1186/s13048-025-01587-5
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