The novel GSDMD inhibitor GI‐Y2 exerts antipyroptotic effects to reduce atherosclerosis

The novel GSDMD inhibitor GI‐Y2 exerts antipyroptotic effects to reduce atherosclerosis

Abstract Introduction Gasdermin D (GSDMD) and the pyroptosis it mediates are importantly involved in cardiovascular diseases (CVDs). Identifying and developing new inhibitors of GSDMD could be a promising strategy for treating pyroptosis‐mediated diseases, such as atherosclerosis. Objectives We aime...

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Main Authors: Xiaoxi Fan, Zhenfeng Cheng, Ruiyin Shao, Keke Ye, Xudong Chen, Xueli Cai, Shanshan Dai, Zhixuan Tang, Si Shi, Wenyuan Zheng, Weijian Huang, Jibo Han, Bozhi Ye
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:Clinical and Translational Medicine
Subjects:
atherosclerosis
gasdermin D
macrophage
pyroptosis
Online Access:https://doi.org/10.1002/ctm2.70263
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