Predictive Value of 5-Methoxytryptophan on Clinical Outcome in Patients with Sepsis Associated Acute Kidney Injury
Xue Sun,1– 3 Yang Liu,4 Yan Liu,5 Shaozheng Ai,1– 3 Pengli Luo1,2 1Department of Nephrology, Affiliated Hospital of Qinghai University, Xining, 810000, People’s Republic of China; 2Clinical Research Center for Chronic Kidney Disease in Qinghai Province, Xining, 810000, People’s Republic of China; 3R...
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Dove Medical Press
2025-05-01
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| author | Sun X Liu Y Liu Y Ai S Luo P |
| author_facet | Sun X Liu Y Liu Y Ai S Luo P |
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| description | Xue Sun,1– 3 Yang Liu,4 Yan Liu,5 Shaozheng Ai,1– 3 Pengli Luo1,2 1Department of Nephrology, Affiliated Hospital of Qinghai University, Xining, 810000, People’s Republic of China; 2Clinical Research Center for Chronic Kidney Disease in Qinghai Province, Xining, 810000, People’s Republic of China; 3Research Center for High Altitude Medicine, Key Laboratory of High Altitude Medicine(Ministry of Education), Key Laboratory of Application and Foundation for High Altitude Medicine Research in Qinghai Province (Qinghai-Utah Joint Research Key Laboratory for High Altitude Medicine), Qinghai University, Xining, 810000, People’s Republic of China; 4Department of Chest Surgery, Affiliated Hospital of Qinghai University, Xining, 810000, People’s Republic of China; 5Department of Public Health, Qinghai University Medical College, Xining, 810000, People’s Republic of ChinaCorrespondence: Pengli Luo, The Affiliated Hospital of Qinghai University, No. 29 Tongren Road, Xining City, 810000, People’s Republic of China, Tel +8615297093191, Email qhlpl2108@163.comPurpose: Our study aims to investigate specific changes in serological 5-MTP expression in sepsis-associated acute kidney injury (SA-AKI) patients and assess its potential as a biomarker for SA-AKI occurrence. Additionally, we seek to evaluate the predictive value of 5-MTP in long-term clinical prognosis following SA-AKI.Patients and Methods: A prospective cohort study included 31 healthy controls and 78 patients diagnosed with sepsis at the Affiliated Hospital of Qinghai University. Following the collection of serological samples, 5-MTP levels were determined using targeted metabolomics.Additionally, we collected clinical data, including blood routine, biochemical, inflammatory indicators and severity of disease. Spearman correlation, COX regression analysis and Kaplan-Meier curves were used to evaluate the correlation between serum 5-MTP and renal function and the value of prognosis.Results: The findings revealed that serum 5-MTP levels were significantly elevated in SA-AKI patients compared to both the healthy control and sepsis groups(P< 0.05), and were associated with Scr, BUN, and eGFR levels(P< 0.05). Additionally, 5-MTP was identified as an independent influencing factor for all-cause mortality in patients with sepsis and SA-AKI. Higher levels of 5-MTP were linked to faster recovery of kidney function, while lower levels were associated with increased 90-day all-cause mortality in SA-AKI patients.Conclusion: 5-MTP may have a protective role in the development of SA-AKI, and an early increase in serological expression of 5-MTP could positively impact the prognosis of sepsis and SA-AKI.Keywords: sepsis associated acute kidney injury1, 5-methoxytryptophan2, prognosis3, 90-day mortality rate4, biomarker5 |
| format | Article |
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| spelling | doaj-art-4f9fe4d56c1447cea935cd86ba41d5e62025-08-20T02:24:08ZengDove Medical PressJournal of Inflammation Research1178-70312025-05-01Volume 18Issue 168656875103364Predictive Value of 5-Methoxytryptophan on Clinical Outcome in Patients with Sepsis Associated Acute Kidney InjurySun X0Liu Y1Liu YAi S2Luo PNephrologyThoracic surgeryNephropathy DepartmentXue Sun,1– 3 Yang Liu,4 Yan Liu,5 Shaozheng Ai,1– 3 Pengli Luo1,2 1Department of Nephrology, Affiliated Hospital of Qinghai University, Xining, 810000, People’s Republic of China; 2Clinical Research Center for Chronic Kidney Disease in Qinghai Province, Xining, 810000, People’s Republic of China; 3Research Center for High Altitude Medicine, Key Laboratory of High Altitude Medicine(Ministry of Education), Key Laboratory of Application and Foundation for High Altitude Medicine Research in Qinghai Province (Qinghai-Utah Joint Research Key Laboratory for High Altitude Medicine), Qinghai University, Xining, 810000, People’s Republic of China; 4Department of Chest Surgery, Affiliated Hospital of Qinghai University, Xining, 810000, People’s Republic of China; 5Department of Public Health, Qinghai University Medical College, Xining, 810000, People’s Republic of ChinaCorrespondence: Pengli Luo, The Affiliated Hospital of Qinghai University, No. 29 Tongren Road, Xining City, 810000, People’s Republic of China, Tel +8615297093191, Email qhlpl2108@163.comPurpose: Our study aims to investigate specific changes in serological 5-MTP expression in sepsis-associated acute kidney injury (SA-AKI) patients and assess its potential as a biomarker for SA-AKI occurrence. Additionally, we seek to evaluate the predictive value of 5-MTP in long-term clinical prognosis following SA-AKI.Patients and Methods: A prospective cohort study included 31 healthy controls and 78 patients diagnosed with sepsis at the Affiliated Hospital of Qinghai University. Following the collection of serological samples, 5-MTP levels were determined using targeted metabolomics.Additionally, we collected clinical data, including blood routine, biochemical, inflammatory indicators and severity of disease. Spearman correlation, COX regression analysis and Kaplan-Meier curves were used to evaluate the correlation between serum 5-MTP and renal function and the value of prognosis.Results: The findings revealed that serum 5-MTP levels were significantly elevated in SA-AKI patients compared to both the healthy control and sepsis groups(P< 0.05), and were associated with Scr, BUN, and eGFR levels(P< 0.05). Additionally, 5-MTP was identified as an independent influencing factor for all-cause mortality in patients with sepsis and SA-AKI. Higher levels of 5-MTP were linked to faster recovery of kidney function, while lower levels were associated with increased 90-day all-cause mortality in SA-AKI patients.Conclusion: 5-MTP may have a protective role in the development of SA-AKI, and an early increase in serological expression of 5-MTP could positively impact the prognosis of sepsis and SA-AKI.Keywords: sepsis associated acute kidney injury1, 5-methoxytryptophan2, prognosis3, 90-day mortality rate4, biomarker5https://www.dovepress.com/predictive-value-of-5-methoxytryptophan-on-clinical-outcome-in-patient-peer-reviewed-fulltext-article-JIRsepsis associated acute kidney injury15-methoxytryptophan2prognosis390-day mortality rate4biomarker5 |
| spellingShingle | Sun X Liu Y Liu Y Ai S Luo P Predictive Value of 5-Methoxytryptophan on Clinical Outcome in Patients with Sepsis Associated Acute Kidney Injury Journal of Inflammation Research sepsis associated acute kidney injury1 5-methoxytryptophan2 prognosis3 90-day mortality rate4 biomarker5 |
| title | Predictive Value of 5-Methoxytryptophan on Clinical Outcome in Patients with Sepsis Associated Acute Kidney Injury |
| title_full | Predictive Value of 5-Methoxytryptophan on Clinical Outcome in Patients with Sepsis Associated Acute Kidney Injury |
| title_fullStr | Predictive Value of 5-Methoxytryptophan on Clinical Outcome in Patients with Sepsis Associated Acute Kidney Injury |
| title_full_unstemmed | Predictive Value of 5-Methoxytryptophan on Clinical Outcome in Patients with Sepsis Associated Acute Kidney Injury |
| title_short | Predictive Value of 5-Methoxytryptophan on Clinical Outcome in Patients with Sepsis Associated Acute Kidney Injury |
| title_sort | predictive value of 5 methoxytryptophan on clinical outcome in patients with sepsis associated acute kidney injury |
| topic | sepsis associated acute kidney injury1 5-methoxytryptophan2 prognosis3 90-day mortality rate4 biomarker5 |
| url | https://www.dovepress.com/predictive-value-of-5-methoxytryptophan-on-clinical-outcome-in-patient-peer-reviewed-fulltext-article-JIR |
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