Cardiometabolic state links neurovascular burden with brain structure and function: Evidence from EEG and MRI
Aging affects brain structure and function alongside metabolic and vascular processes leading to energetic impairments. While local neurometabolic dysfunction in aging is well-documented, the influence of systemic cardiometabolic and vascular markers on brain structure and function remains less unde...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-08-01
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| Series: | NeuroImage |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1053811925003118 |
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| author | Daniel Franco-O’Byrne Ana M. Castro-Laguardia Carolina Delgado James M. Shine David Huepe Raul González-Gomez Enzo Tagliazucchi Cecilia Gonzalez-Campo Agustín Ibañez Vicente Medel |
| author_facet | Daniel Franco-O’Byrne Ana M. Castro-Laguardia Carolina Delgado James M. Shine David Huepe Raul González-Gomez Enzo Tagliazucchi Cecilia Gonzalez-Campo Agustín Ibañez Vicente Medel |
| author_sort | Daniel Franco-O’Byrne |
| collection | DOAJ |
| description | Aging affects brain structure and function alongside metabolic and vascular processes leading to energetic impairments. While local neurometabolic dysfunction in aging is well-documented, the influence of systemic cardiometabolic and vascular markers on brain structure and function remains less understood. We examine the link between cardiometabolic dysfunction (measured by an allostatic load index) and neurovascular burden (measured by white matter hyperintensities), and their associations with brain changes, including ventricular and hippocampal volume, as well as EEG activity, across the adult lifesplan. Analyzing data from 196 healthy individuals across ages (20–75 years), we found a significant positive correlation between allostatic load index and white-matter hyperintensities, irrespective of age. White matter hyperintensities are also positively linked with ventricular enlargement, but not hippocampal atrophy. The allostatic load index mediated the relationship between white-matter hyperintensities and ventricular volume. Regarding brain function, changes in the spectral aperiodic exponent but not periodic alpha power were linked to white matter hyperintensities and the allostatic load index. The allostatic load index also mediated the relationship between spectral aperiodic exponent and white matter hyperintensities. Thus, findings suggest that the cardiometabolic state, as measured by the allostatic load index, plays a crucial role in brain health in aging, particularly influencing ventricular enlargement and increased aperiodic activity. |
| format | Article |
| id | doaj-art-4f9d7c4ae44f4e3888eb4f8a37466347 |
| institution | Kabale University |
| issn | 1095-9572 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage |
| spelling | doaj-art-4f9d7c4ae44f4e3888eb4f8a374663472025-08-20T03:30:47ZengElsevierNeuroImage1095-95722025-08-0131612130810.1016/j.neuroimage.2025.121308Cardiometabolic state links neurovascular burden with brain structure and function: Evidence from EEG and MRIDaniel Franco-O’Byrne0Ana M. Castro-Laguardia1Carolina Delgado2James M. Shine3David Huepe4Raul González-Gomez5Enzo Tagliazucchi6Cecilia Gonzalez-Campo7Agustín Ibañez8Vicente Medel9Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ibáñez, Santiago, Chile; Center for Social and Cognitive Neuroscience (CSCN), School of Psychology, Universidad Adolfo Ibáñez, Santiago, ChileLatin American Brain Health Institute (BrainLat), Universidad Adolfo Ibáñez, Santiago, Chile; Center for Social and Cognitive Neuroscience (CSCN), School of Psychology, Universidad Adolfo Ibáñez, Santiago, ChileDepartamento de Neurociencia, Facultad de Medicina, Universidad de Chile, Santiago, ChileThe University of Sydney, New South Wales, AustraliaCenter for Social and Cognitive Neuroscience (CSCN), School of Psychology, Universidad Adolfo Ibáñez, Santiago, ChileLatin American Brain Health Institute (BrainLat), Universidad Adolfo Ibáñez, Santiago, ChileLatin American Brain Health Institute (BrainLat), Universidad Adolfo Ibáñez, Santiago, ChileConsejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), ArgentinaLatin American Brain Health Institute (BrainLat), Universidad Adolfo Ibáñez, Santiago, Chile; Centro de Neurociencias Cognitivas, Universidad de San Andrés, Victoria, Provincia de Buenos Aires, Argentina; Global Brain Health Institute (GBHI), University of California San Francisco (UCSF), USA University of Trinity Dublin, Ireland; Corresponding authors.Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ibáñez, Santiago, Chile; Corresponding authors.Aging affects brain structure and function alongside metabolic and vascular processes leading to energetic impairments. While local neurometabolic dysfunction in aging is well-documented, the influence of systemic cardiometabolic and vascular markers on brain structure and function remains less understood. We examine the link between cardiometabolic dysfunction (measured by an allostatic load index) and neurovascular burden (measured by white matter hyperintensities), and their associations with brain changes, including ventricular and hippocampal volume, as well as EEG activity, across the adult lifesplan. Analyzing data from 196 healthy individuals across ages (20–75 years), we found a significant positive correlation between allostatic load index and white-matter hyperintensities, irrespective of age. White matter hyperintensities are also positively linked with ventricular enlargement, but not hippocampal atrophy. The allostatic load index mediated the relationship between white-matter hyperintensities and ventricular volume. Regarding brain function, changes in the spectral aperiodic exponent but not periodic alpha power were linked to white matter hyperintensities and the allostatic load index. The allostatic load index also mediated the relationship between spectral aperiodic exponent and white matter hyperintensities. Thus, findings suggest that the cardiometabolic state, as measured by the allostatic load index, plays a crucial role in brain health in aging, particularly influencing ventricular enlargement and increased aperiodic activity.http://www.sciencedirect.com/science/article/pii/S1053811925003118Cardiometabolic stateWhite matter hyperintensitiesNeurovascular burdenAperiodic activityVentricular enlargement |
| spellingShingle | Daniel Franco-O’Byrne Ana M. Castro-Laguardia Carolina Delgado James M. Shine David Huepe Raul González-Gomez Enzo Tagliazucchi Cecilia Gonzalez-Campo Agustín Ibañez Vicente Medel Cardiometabolic state links neurovascular burden with brain structure and function: Evidence from EEG and MRI NeuroImage Cardiometabolic state White matter hyperintensities Neurovascular burden Aperiodic activity Ventricular enlargement |
| title | Cardiometabolic state links neurovascular burden with brain structure and function: Evidence from EEG and MRI |
| title_full | Cardiometabolic state links neurovascular burden with brain structure and function: Evidence from EEG and MRI |
| title_fullStr | Cardiometabolic state links neurovascular burden with brain structure and function: Evidence from EEG and MRI |
| title_full_unstemmed | Cardiometabolic state links neurovascular burden with brain structure and function: Evidence from EEG and MRI |
| title_short | Cardiometabolic state links neurovascular burden with brain structure and function: Evidence from EEG and MRI |
| title_sort | cardiometabolic state links neurovascular burden with brain structure and function evidence from eeg and mri |
| topic | Cardiometabolic state White matter hyperintensities Neurovascular burden Aperiodic activity Ventricular enlargement |
| url | http://www.sciencedirect.com/science/article/pii/S1053811925003118 |
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