The First Example of a <i>Model</i> Amphiphilic Polymer Conetwork Containing a Hydrophobic Oligopeptide: The Case of End-Linked Tetra[Poly(ethylene glycol)-<i>b</i>-oligo(<i>L</i>-alanine)]
Herein we describe the development of the first <i>model</i> amphiphilic polymer conetwork (APCN) comprising a short hydrophobic hexa(<i>L</i>-alanine) segment being the outer block of an amphiphilic four-armed star block copolymer with inner poly(ethylene glycol) (PEG) block...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-04-01
|
| Series: | Gels |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2310-2861/11/5/331 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850257011646660608 |
|---|---|
| author | Demetris E. Apostolides George Michael Costas S. Patrickios Takamasa Sakai Iro Kyroglou Maria Kasimatis Hermis Iatrou Sylvain Prévost Michael Gradzielski |
| author_facet | Demetris E. Apostolides George Michael Costas S. Patrickios Takamasa Sakai Iro Kyroglou Maria Kasimatis Hermis Iatrou Sylvain Prévost Michael Gradzielski |
| author_sort | Demetris E. Apostolides |
| collection | DOAJ |
| description | Herein we describe the development of the first <i>model</i> amphiphilic polymer conetwork (APCN) comprising a short hydrophobic hexa(<i>L</i>-alanine) segment being the outer block of an amphiphilic four-armed star block copolymer with inner poly(ethylene glycol) (PEG) blocks bearing benzaldehyde terminal groups and end-linked with another four-armed star PEG homopolymer (tetraPEG star) bearing aryl-substituted acylhydrazide terminal groups. The present successful synthesis that yielded the peptide-containing model APCN was preceded by several unsuccessful efforts that followed different synthetic strategies. In addition to the synthetic work, we also present the structural characterization of the peptide-bearing APCN in D<sub>2</sub>O using small-angle neutron scattering (SANS). |
| format | Article |
| id | doaj-art-4f9d2054380e4a7fa1e0ccd8ea839051 |
| institution | OA Journals |
| issn | 2310-2861 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Gels |
| spelling | doaj-art-4f9d2054380e4a7fa1e0ccd8ea8390512025-08-20T01:56:31ZengMDPI AGGels2310-28612025-04-0111533110.3390/gels11050331The First Example of a <i>Model</i> Amphiphilic Polymer Conetwork Containing a Hydrophobic Oligopeptide: The Case of End-Linked Tetra[Poly(ethylene glycol)-<i>b</i>-oligo(<i>L</i>-alanine)]Demetris E. Apostolides0George Michael1Costas S. Patrickios2Takamasa Sakai3Iro Kyroglou4Maria Kasimatis5Hermis Iatrou6Sylvain Prévost7Michael Gradzielski8Department of Chemistry, University of Cyprus, P.O. Box 20537, Nicosia 1678, CyprusDepartment of Chemistry, University of Cyprus, P.O. Box 20537, Nicosia 1678, CyprusDepartment of Chemistry, University of Cyprus, P.O. Box 20537, Nicosia 1678, CyprusDepartment of Bioengineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, JapanDepartment of Chemistry, National and Kapodistrian University of Athens, Zografou, 15771 Athens, GreeceDepartment of Chemistry, National and Kapodistrian University of Athens, Zografou, 15771 Athens, GreeceDepartment of Chemistry, National and Kapodistrian University of Athens, Zografou, 15771 Athens, GreeceInstitut Max von Laue—Paul Langevin (ILL), 71 Avenue des Martyrs—CS 20156, 38042 Grenoble, FranceStranski-Laboratorium für Physikalische und Theoretische Chemie, Institut für Chemie, Technische Universität Berlin, Straße des 17. Juni 124, 10623 Berlin, GermanyHerein we describe the development of the first <i>model</i> amphiphilic polymer conetwork (APCN) comprising a short hydrophobic hexa(<i>L</i>-alanine) segment being the outer block of an amphiphilic four-armed star block copolymer with inner poly(ethylene glycol) (PEG) blocks bearing benzaldehyde terminal groups and end-linked with another four-armed star PEG homopolymer (tetraPEG star) bearing aryl-substituted acylhydrazide terminal groups. The present successful synthesis that yielded the peptide-containing model APCN was preceded by several unsuccessful efforts that followed different synthetic strategies. In addition to the synthetic work, we also present the structural characterization of the peptide-bearing APCN in D<sub>2</sub>O using small-angle neutron scattering (SANS).https://www.mdpi.com/2310-2861/11/5/331amphiphilic polymer conetworkspeptidestetraPEGSANSaqueous swelling |
| spellingShingle | Demetris E. Apostolides George Michael Costas S. Patrickios Takamasa Sakai Iro Kyroglou Maria Kasimatis Hermis Iatrou Sylvain Prévost Michael Gradzielski The First Example of a <i>Model</i> Amphiphilic Polymer Conetwork Containing a Hydrophobic Oligopeptide: The Case of End-Linked Tetra[Poly(ethylene glycol)-<i>b</i>-oligo(<i>L</i>-alanine)] Gels amphiphilic polymer conetworks peptides tetraPEG SANS aqueous swelling |
| title | The First Example of a <i>Model</i> Amphiphilic Polymer Conetwork Containing a Hydrophobic Oligopeptide: The Case of End-Linked Tetra[Poly(ethylene glycol)-<i>b</i>-oligo(<i>L</i>-alanine)] |
| title_full | The First Example of a <i>Model</i> Amphiphilic Polymer Conetwork Containing a Hydrophobic Oligopeptide: The Case of End-Linked Tetra[Poly(ethylene glycol)-<i>b</i>-oligo(<i>L</i>-alanine)] |
| title_fullStr | The First Example of a <i>Model</i> Amphiphilic Polymer Conetwork Containing a Hydrophobic Oligopeptide: The Case of End-Linked Tetra[Poly(ethylene glycol)-<i>b</i>-oligo(<i>L</i>-alanine)] |
| title_full_unstemmed | The First Example of a <i>Model</i> Amphiphilic Polymer Conetwork Containing a Hydrophobic Oligopeptide: The Case of End-Linked Tetra[Poly(ethylene glycol)-<i>b</i>-oligo(<i>L</i>-alanine)] |
| title_short | The First Example of a <i>Model</i> Amphiphilic Polymer Conetwork Containing a Hydrophobic Oligopeptide: The Case of End-Linked Tetra[Poly(ethylene glycol)-<i>b</i>-oligo(<i>L</i>-alanine)] |
| title_sort | first example of a i model i amphiphilic polymer conetwork containing a hydrophobic oligopeptide the case of end linked tetra poly ethylene glycol i b i oligo i l i alanine |
| topic | amphiphilic polymer conetworks peptides tetraPEG SANS aqueous swelling |
| url | https://www.mdpi.com/2310-2861/11/5/331 |
| work_keys_str_mv | AT demetriseapostolides thefirstexampleofaimodeliamphiphilicpolymerconetworkcontainingahydrophobicoligopeptidethecaseofendlinkedtetrapolyethyleneglycolibioligoilialanine AT georgemichael thefirstexampleofaimodeliamphiphilicpolymerconetworkcontainingahydrophobicoligopeptidethecaseofendlinkedtetrapolyethyleneglycolibioligoilialanine AT costasspatrickios thefirstexampleofaimodeliamphiphilicpolymerconetworkcontainingahydrophobicoligopeptidethecaseofendlinkedtetrapolyethyleneglycolibioligoilialanine AT takamasasakai thefirstexampleofaimodeliamphiphilicpolymerconetworkcontainingahydrophobicoligopeptidethecaseofendlinkedtetrapolyethyleneglycolibioligoilialanine AT irokyroglou thefirstexampleofaimodeliamphiphilicpolymerconetworkcontainingahydrophobicoligopeptidethecaseofendlinkedtetrapolyethyleneglycolibioligoilialanine AT mariakasimatis thefirstexampleofaimodeliamphiphilicpolymerconetworkcontainingahydrophobicoligopeptidethecaseofendlinkedtetrapolyethyleneglycolibioligoilialanine AT hermisiatrou thefirstexampleofaimodeliamphiphilicpolymerconetworkcontainingahydrophobicoligopeptidethecaseofendlinkedtetrapolyethyleneglycolibioligoilialanine AT sylvainprevost thefirstexampleofaimodeliamphiphilicpolymerconetworkcontainingahydrophobicoligopeptidethecaseofendlinkedtetrapolyethyleneglycolibioligoilialanine AT michaelgradzielski thefirstexampleofaimodeliamphiphilicpolymerconetworkcontainingahydrophobicoligopeptidethecaseofendlinkedtetrapolyethyleneglycolibioligoilialanine AT demetriseapostolides firstexampleofaimodeliamphiphilicpolymerconetworkcontainingahydrophobicoligopeptidethecaseofendlinkedtetrapolyethyleneglycolibioligoilialanine AT georgemichael firstexampleofaimodeliamphiphilicpolymerconetworkcontainingahydrophobicoligopeptidethecaseofendlinkedtetrapolyethyleneglycolibioligoilialanine AT costasspatrickios firstexampleofaimodeliamphiphilicpolymerconetworkcontainingahydrophobicoligopeptidethecaseofendlinkedtetrapolyethyleneglycolibioligoilialanine AT takamasasakai firstexampleofaimodeliamphiphilicpolymerconetworkcontainingahydrophobicoligopeptidethecaseofendlinkedtetrapolyethyleneglycolibioligoilialanine AT irokyroglou firstexampleofaimodeliamphiphilicpolymerconetworkcontainingahydrophobicoligopeptidethecaseofendlinkedtetrapolyethyleneglycolibioligoilialanine AT mariakasimatis firstexampleofaimodeliamphiphilicpolymerconetworkcontainingahydrophobicoligopeptidethecaseofendlinkedtetrapolyethyleneglycolibioligoilialanine AT hermisiatrou firstexampleofaimodeliamphiphilicpolymerconetworkcontainingahydrophobicoligopeptidethecaseofendlinkedtetrapolyethyleneglycolibioligoilialanine AT sylvainprevost firstexampleofaimodeliamphiphilicpolymerconetworkcontainingahydrophobicoligopeptidethecaseofendlinkedtetrapolyethyleneglycolibioligoilialanine AT michaelgradzielski firstexampleofaimodeliamphiphilicpolymerconetworkcontainingahydrophobicoligopeptidethecaseofendlinkedtetrapolyethyleneglycolibioligoilialanine |