The First Example of a <i>Model</i> Amphiphilic Polymer Conetwork Containing a Hydrophobic Oligopeptide: The Case of End-Linked Tetra[Poly(ethylene glycol)-<i>b</i>-oligo(<i>L</i>-alanine)]

The First Example of a <i>Model</i> Amphiphilic Polymer Conetwork Containing a Hydrophobic Oligopeptide: The Case of End-Linked Tetra[Poly(ethylene glycol)-<i>b</i>-oligo(<i>L</i>-alanine)]

Herein we describe the development of the first <i>model</i> amphiphilic polymer conetwork (APCN) comprising a short hydrophobic hexa(<i>L</i>-alanine) segment being the outer block of an amphiphilic four-armed star block copolymer with inner poly(ethylene glycol) (PEG) block...

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Bibliographic Details
Main Authors: Demetris E. Apostolides, George Michael, Costas S. Patrickios, Takamasa Sakai, Iro Kyroglou, Maria Kasimatis, Hermis Iatrou, Sylvain Prévost, Michael Gradzielski
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Gels
Subjects:
amphiphilic polymer conetworks
peptides
tetraPEG
SANS
aqueous swelling
Online Access:https://www.mdpi.com/2310-2861/11/5/331
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Summary:Herein we describe the development of the first <i>model</i> amphiphilic polymer conetwork (APCN) comprising a short hydrophobic hexa(<i>L</i>-alanine) segment being the outer block of an amphiphilic four-armed star block copolymer with inner poly(ethylene glycol) (PEG) blocks bearing benzaldehyde terminal groups and end-linked with another four-armed star PEG homopolymer (tetraPEG star) bearing aryl-substituted acylhydrazide terminal groups. The present successful synthesis that yielded the peptide-containing model APCN was preceded by several unsuccessful efforts that followed different synthetic strategies. In addition to the synthetic work, we also present the structural characterization of the peptide-bearing APCN in D<sub>2</sub>O using small-angle neutron scattering (SANS).
ISSN:2310-2861

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