Right ventricular morphology and the onset of dyspnea: the MESA-right ventricle study.
<h4>Background</h4>The association of right ventricular (RV) structure and function with symptoms in individuals without cardiopulmonary disease is unknown. We hypothesized that greater RV mass and RV end-diastolic volume (RVEDV), smaller RV stroke volume (RVSV), and lower RV ejection fr...
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0056826&type=printable |
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| author | Michael R Kaufmann R Graham Barr João A C Lima Amy Praestgaard Aditya Jain Harikrishna Tandri David A Bluemke Steven M Kawut |
| author_facet | Michael R Kaufmann R Graham Barr João A C Lima Amy Praestgaard Aditya Jain Harikrishna Tandri David A Bluemke Steven M Kawut |
| author_sort | Michael R Kaufmann |
| collection | DOAJ |
| description | <h4>Background</h4>The association of right ventricular (RV) structure and function with symptoms in individuals without cardiopulmonary disease is unknown. We hypothesized that greater RV mass and RV end-diastolic volume (RVEDV), smaller RV stroke volume (RVSV), and lower RV ejection fraction (RVEF) measured by cardiac magnetic resonance imaging (MRI) in participants free of clinical cardiovascular disease at baseline would be associated with a greater risk of self-reported dyspnea.<h4>Methods</h4>The Multi-Ethnic Study of Atherosclerosis (MESA) performed cardiac MRIs on participants without clinical cardiovascular disease between 2000 and 2002. We excluded subjects who reported "prevalent" dyspnea at the first assessment (24 months). The presence of dyspnea was assessed at 24 months, 42 months, and 60 months from baseline. Cox proportional hazards models were used to examine the relationship between RV measures and incident dyspnea.<h4>Results</h4>In the final study sample (N = 2763), there were significant interactions between RV measures and sex in terms of the risk of dyspnea (p<0.05). Among men (N = 1453), lower RV mass (p = 0.003), smaller RVEDV (p<0.001), smaller RV end-systolic volume (RVESV) (p = 0.03) and decreased RVSV (p<0.001) were associated with an increased risk of developing dyspnea after adjusting for covariates. Associations remained after adjusting for left ventricular function and lung function. However, there were no significant associations between RV measures and the risk of dyspnea in women.<h4>Conclusions</h4>Lower RV mass and smaller RV volumes were associated with an increased risk of dyspnea in men, but not in women. |
| format | Article |
| id | doaj-art-4f996ba9a17f4677bbd1e8f7960c9dbe |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-4f996ba9a17f4677bbd1e8f7960c9dbe2025-08-20T02:30:38ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0182e5682610.1371/journal.pone.0056826Right ventricular morphology and the onset of dyspnea: the MESA-right ventricle study.Michael R KaufmannR Graham BarrJoão A C LimaAmy PraestgaardAditya JainHarikrishna TandriDavid A BluemkeSteven M Kawut<h4>Background</h4>The association of right ventricular (RV) structure and function with symptoms in individuals without cardiopulmonary disease is unknown. We hypothesized that greater RV mass and RV end-diastolic volume (RVEDV), smaller RV stroke volume (RVSV), and lower RV ejection fraction (RVEF) measured by cardiac magnetic resonance imaging (MRI) in participants free of clinical cardiovascular disease at baseline would be associated with a greater risk of self-reported dyspnea.<h4>Methods</h4>The Multi-Ethnic Study of Atherosclerosis (MESA) performed cardiac MRIs on participants without clinical cardiovascular disease between 2000 and 2002. We excluded subjects who reported "prevalent" dyspnea at the first assessment (24 months). The presence of dyspnea was assessed at 24 months, 42 months, and 60 months from baseline. Cox proportional hazards models were used to examine the relationship between RV measures and incident dyspnea.<h4>Results</h4>In the final study sample (N = 2763), there were significant interactions between RV measures and sex in terms of the risk of dyspnea (p<0.05). Among men (N = 1453), lower RV mass (p = 0.003), smaller RVEDV (p<0.001), smaller RV end-systolic volume (RVESV) (p = 0.03) and decreased RVSV (p<0.001) were associated with an increased risk of developing dyspnea after adjusting for covariates. Associations remained after adjusting for left ventricular function and lung function. However, there were no significant associations between RV measures and the risk of dyspnea in women.<h4>Conclusions</h4>Lower RV mass and smaller RV volumes were associated with an increased risk of dyspnea in men, but not in women.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0056826&type=printable |
| spellingShingle | Michael R Kaufmann R Graham Barr João A C Lima Amy Praestgaard Aditya Jain Harikrishna Tandri David A Bluemke Steven M Kawut Right ventricular morphology and the onset of dyspnea: the MESA-right ventricle study. PLoS ONE |
| title | Right ventricular morphology and the onset of dyspnea: the MESA-right ventricle study. |
| title_full | Right ventricular morphology and the onset of dyspnea: the MESA-right ventricle study. |
| title_fullStr | Right ventricular morphology and the onset of dyspnea: the MESA-right ventricle study. |
| title_full_unstemmed | Right ventricular morphology and the onset of dyspnea: the MESA-right ventricle study. |
| title_short | Right ventricular morphology and the onset of dyspnea: the MESA-right ventricle study. |
| title_sort | right ventricular morphology and the onset of dyspnea the mesa right ventricle study |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0056826&type=printable |
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