Frankincense ameliorates endometriosis via inducing apoptosis and reducing adhesion
Background: Frankincense, a resin derived from trees of the Boswellia genus, has been used as an incense and a type of herbal medicine for treating inflammatory diseases such arthritis, chronic bowel illness, and asthma. While endometriosis is a well-known inflammatory gynecological illness caused b...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-06-01
|
| Series: | Integrative Medicine Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213422023000264 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850260519434321920 |
|---|---|
| author | Min Kyoung Cho Jung-Sook Jin Yunju Jo Jung Ho Han Su Shin Sung-Jin Bae Dongryeol Ryu Jongkil Joo Jang-Kyung Park Ki-Tae Ha |
| author_facet | Min Kyoung Cho Jung-Sook Jin Yunju Jo Jung Ho Han Su Shin Sung-Jin Bae Dongryeol Ryu Jongkil Joo Jang-Kyung Park Ki-Tae Ha |
| author_sort | Min Kyoung Cho |
| collection | DOAJ |
| description | Background: Frankincense, a resin derived from trees of the Boswellia genus, has been used as an incense and a type of herbal medicine for treating inflammatory diseases such arthritis, chronic bowel illness, and asthma. While endometriosis is a well-known inflammatory gynecological illness caused by the ectopic attachment and development of uterine tissue over the menstrual cycle, the impact of frankincense on this illness is poorly understood. The purpose of this study was to explore the effects of frankincense on endometriosis. Methods: We used a network pharmacological assessment, in vitro and in vivo investigations with a human endometriotic cell line as well as a syngeneic uterine transfer mouse model. High-performance liquid chromatographic analysis was used to compare water-extracted frankincense (Fr) to its reference compounds and validate the sample. Results: A network pharmacological analysis suggested a positive effect of Fr on endometriosis. Fr relieved endometriosis by reducing ectopic endometrial adherence and development, according to both in vivo and in vitro models. We suggested that the ER stress/p53-apoptosis and chemokine-migration/adhesion pathways underlie Fr's anti-endometriotic action using RNA sequencing and bioinformatic analysis. Conclusion: This study revealed the potential effect of Fr on endometriosis using an experimental investigation. Fr may have the potential to be an effective and safe treatment for endometriosis. |
| format | Article |
| id | doaj-art-4f97a46570bb4dd3a00c5a4fa7cbfe9d |
| institution | OA Journals |
| issn | 2213-4220 |
| language | English |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Integrative Medicine Research |
| spelling | doaj-art-4f97a46570bb4dd3a00c5a4fa7cbfe9d2025-08-20T01:55:37ZengElsevierIntegrative Medicine Research2213-42202023-06-0112210094710.1016/j.imr.2023.100947Frankincense ameliorates endometriosis via inducing apoptosis and reducing adhesionMin Kyoung Cho0Jung-Sook Jin1Yunju Jo2Jung Ho Han3Su Shin4Sung-Jin Bae5Dongryeol Ryu6Jongkil Joo7Jang-Kyung Park8Ki-Tae Ha9Korean Medical Research Center for Healthy Aging, Pusan National University, Yangsan, Republic of Korea; Department of Molecular Biology and Immunology, Kosin University College of Medicine, Busan, Republic of KoreaKorean Medical Research Center for Healthy Aging, Pusan National University, Yangsan, Republic of KoreaDepartment of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon, Republic of KoreaKorean Medical Research Center for Healthy Aging, Pusan National University, Yangsan, Republic of Korea; Department of Korean Medical Science, School of Korean Medicine, Pusan National University, Yangsan, Republic of KoreaDepartment of Korean Medical Science, School of Korean Medicine, Pusan National University, Yangsan, Republic of KoreaDepartment of Molecular Biology and Immunology, Kosin University College of Medicine, Busan, Republic of KoreaDepartment of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon, Republic of KoreaDepartment of Korean Obstetrics and Gynecology, Pusan National University Korean Medicine Hospital, Yangsan, Republic of KoreaDepartment of Obstetrics and Gynecology, Pusan National University Hospital, Busan, Republic of Korea; Corresponding authors at: Department of Korean Medicine Obstetrics and Gynecology, Pusan National University Korean Medicine Hospital, Geumo-ro 20, Yangsan, Gyeongsangnam-do, 50612, Republic of Korea (J.-K. Park); Department of Korean Medical Science, School of Korean Medicine, Pusan National University, Busandaehak-ro 49, Yangsan, Gyeongsangnam-do, 50612, Republic of Korea (K.-H. Ha).Korean Medical Research Center for Healthy Aging, Pusan National University, Yangsan, Republic of Korea; Department of Korean Medical Science, School of Korean Medicine, Pusan National University, Yangsan, Republic of Korea; Corresponding authors at: Department of Korean Medicine Obstetrics and Gynecology, Pusan National University Korean Medicine Hospital, Geumo-ro 20, Yangsan, Gyeongsangnam-do, 50612, Republic of Korea (J.-K. Park); Department of Korean Medical Science, School of Korean Medicine, Pusan National University, Busandaehak-ro 49, Yangsan, Gyeongsangnam-do, 50612, Republic of Korea (K.-H. Ha).Background: Frankincense, a resin derived from trees of the Boswellia genus, has been used as an incense and a type of herbal medicine for treating inflammatory diseases such arthritis, chronic bowel illness, and asthma. While endometriosis is a well-known inflammatory gynecological illness caused by the ectopic attachment and development of uterine tissue over the menstrual cycle, the impact of frankincense on this illness is poorly understood. The purpose of this study was to explore the effects of frankincense on endometriosis. Methods: We used a network pharmacological assessment, in vitro and in vivo investigations with a human endometriotic cell line as well as a syngeneic uterine transfer mouse model. High-performance liquid chromatographic analysis was used to compare water-extracted frankincense (Fr) to its reference compounds and validate the sample. Results: A network pharmacological analysis suggested a positive effect of Fr on endometriosis. Fr relieved endometriosis by reducing ectopic endometrial adherence and development, according to both in vivo and in vitro models. We suggested that the ER stress/p53-apoptosis and chemokine-migration/adhesion pathways underlie Fr's anti-endometriotic action using RNA sequencing and bioinformatic analysis. Conclusion: This study revealed the potential effect of Fr on endometriosis using an experimental investigation. Fr may have the potential to be an effective and safe treatment for endometriosis.http://www.sciencedirect.com/science/article/pii/S2213422023000264AdhesionApoptosisEndometriosisFrankincense |
| spellingShingle | Min Kyoung Cho Jung-Sook Jin Yunju Jo Jung Ho Han Su Shin Sung-Jin Bae Dongryeol Ryu Jongkil Joo Jang-Kyung Park Ki-Tae Ha Frankincense ameliorates endometriosis via inducing apoptosis and reducing adhesion Integrative Medicine Research Adhesion Apoptosis Endometriosis Frankincense |
| title | Frankincense ameliorates endometriosis via inducing apoptosis and reducing adhesion |
| title_full | Frankincense ameliorates endometriosis via inducing apoptosis and reducing adhesion |
| title_fullStr | Frankincense ameliorates endometriosis via inducing apoptosis and reducing adhesion |
| title_full_unstemmed | Frankincense ameliorates endometriosis via inducing apoptosis and reducing adhesion |
| title_short | Frankincense ameliorates endometriosis via inducing apoptosis and reducing adhesion |
| title_sort | frankincense ameliorates endometriosis via inducing apoptosis and reducing adhesion |
| topic | Adhesion Apoptosis Endometriosis Frankincense |
| url | http://www.sciencedirect.com/science/article/pii/S2213422023000264 |
| work_keys_str_mv | AT minkyoungcho frankincenseamelioratesendometriosisviainducingapoptosisandreducingadhesion AT jungsookjin frankincenseamelioratesendometriosisviainducingapoptosisandreducingadhesion AT yunjujo frankincenseamelioratesendometriosisviainducingapoptosisandreducingadhesion AT junghohan frankincenseamelioratesendometriosisviainducingapoptosisandreducingadhesion AT sushin frankincenseamelioratesendometriosisviainducingapoptosisandreducingadhesion AT sungjinbae frankincenseamelioratesendometriosisviainducingapoptosisandreducingadhesion AT dongryeolryu frankincenseamelioratesendometriosisviainducingapoptosisandreducingadhesion AT jongkiljoo frankincenseamelioratesendometriosisviainducingapoptosisandreducingadhesion AT jangkyungpark frankincenseamelioratesendometriosisviainducingapoptosisandreducingadhesion AT kitaeha frankincenseamelioratesendometriosisviainducingapoptosisandreducingadhesion |