Cardiac function evaluation in healthy volunteers and patients with implantable cardioverter-defibrillators using high-bandwidth spoiled gradient-echo cine
Background: Implantable cardioverter-defibrillators (ICDs) cause banding artifacts around areas of B0 inhomogeneity in conventional steady-state free precession (SSFP) cine sequences. Alternatively, high-bandwidth gradient-recalled echo (GRE) cine sequences can be used to minimize artifacts in the m...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-01-01
|
| Series: | Journal of Cardiovascular Magnetic Resonance |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1097664725000559 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850124539920384000 |
|---|---|
| author | Calder D. Sheagren Naseem Shadafny Terenz Escartin Maria Terricabras Christopher C. Cheung Idan Roifman Graham A. Wright |
| author_facet | Calder D. Sheagren Naseem Shadafny Terenz Escartin Maria Terricabras Christopher C. Cheung Idan Roifman Graham A. Wright |
| author_sort | Calder D. Sheagren |
| collection | DOAJ |
| description | Background: Implantable cardioverter-defibrillators (ICDs) cause banding artifacts around areas of B0 inhomogeneity in conventional steady-state free precession (SSFP) cine sequences. Alternatively, high-bandwidth gradient-recalled echo (GRE) cine sequences can be used to minimize artifacts in the myocardium. In this study, we assessed the bias and interobserver variability in cardiac volumes and ejection fractions between GRE cines in acquired in the presence of ICDS and ground-truth SSFP cines (without ICDs present) in a population of healthy volunteers. Further, a small cohort of ICD patients was recruited and scanned to demonstrate clinical feasibility. Methods: High-bandwidth GRE cine was performed in 11 healthy volunteers with taped ICDs mimicking clinical implants. After the ICD was removed, ground-truth SSFP cine was performed. Two observers separately assessed image quality metrics and contoured the cine images to return cardiac volumes and ejection fractions. Nine patients with an ICD were also scanned with the GRE cine protocol before contrast administration; data were contoured by two observers and analyzed for interobserver agreement. Results: In the healthy volunteer dataset, no statistically significant differences were found when comparing volumes or ejection fractions between sequences (p > 0.05). Statistically significant differences were found when comparing right ventricular ejection fraction (RVEF) (p = 0.009) and right ventricular end-systolic volume (p = 0.029) between observers, with no other significant interobserver differences. The interobserver variability of patient left ventricular ejection fraction and RVEF data was 3–4%, with lower image quality metrics for patient scans than volunteer scans. Conclusion: GRE cine imaging in healthy volunteers with taped ICDs demonstrated good agreement with SSFP cine, but increased interobserver variability. In patients, reducing the breath-hold duration caused a decrease in image quality, with GRE cine imaging in patients with ICDs demonstrating poorer image quality and greater interobserver variability than in healthy volunteer studies. Future work is needed to improve GRE cine image quality in patients with ICDs to reduce interobserver variability and improve clinical confidence. |
| format | Article |
| id | doaj-art-4f95579723a04ad7b9e76eee5b9ff9f5 |
| institution | OA Journals |
| issn | 1097-6647 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Cardiovascular Magnetic Resonance |
| spelling | doaj-art-4f95579723a04ad7b9e76eee5b9ff9f52025-08-20T02:34:16ZengElsevierJournal of Cardiovascular Magnetic Resonance1097-66472025-01-0127110189310.1016/j.jocmr.2025.101893Cardiac function evaluation in healthy volunteers and patients with implantable cardioverter-defibrillators using high-bandwidth spoiled gradient-echo cineCalder D. Sheagren0Naseem Shadafny1Terenz Escartin2Maria Terricabras3Christopher C. Cheung4Idan Roifman5Graham A. Wright6Department of Medical Biophysics, University of Toronto, 101 College St, Toronto, M5G 1L7 Ontario, Canada; Physical Sciences Platform, Sunnybrook Research Institute, 2075 Bayview Ave, Toronto, M4N 3M5 Ontario, Canada; Corresponding author.Schulich Heart Research Program, Sunnybrook Health Sciences Centre, 2075 Bayview Ave, Toronto, M4N 3M5 Ontario, CanadaDepartment of Medical Biophysics, University of Toronto, 101 College St, Toronto, M5G 1L7 Ontario, Canada; Physical Sciences Platform, Sunnybrook Research Institute, 2075 Bayview Ave, Toronto, M4N 3M5 Ontario, CanadaSchulich Heart Research Program, Sunnybrook Health Sciences Centre, 2075 Bayview Ave, Toronto, M4N 3M5 Ontario, CanadaSchulich Heart Research Program, Sunnybrook Health Sciences Centre, 2075 Bayview Ave, Toronto, M4N 3M5 Ontario, CanadaSchulich Heart Research Program, Sunnybrook Health Sciences Centre, 2075 Bayview Ave, Toronto, M4N 3M5 Ontario, CanadaDepartment of Medical Biophysics, University of Toronto, 101 College St, Toronto, M5G 1L7 Ontario, Canada; Physical Sciences Platform, Sunnybrook Research Institute, 2075 Bayview Ave, Toronto, M4N 3M5 Ontario, CanadaBackground: Implantable cardioverter-defibrillators (ICDs) cause banding artifacts around areas of B0 inhomogeneity in conventional steady-state free precession (SSFP) cine sequences. Alternatively, high-bandwidth gradient-recalled echo (GRE) cine sequences can be used to minimize artifacts in the myocardium. In this study, we assessed the bias and interobserver variability in cardiac volumes and ejection fractions between GRE cines in acquired in the presence of ICDS and ground-truth SSFP cines (without ICDs present) in a population of healthy volunteers. Further, a small cohort of ICD patients was recruited and scanned to demonstrate clinical feasibility. Methods: High-bandwidth GRE cine was performed in 11 healthy volunteers with taped ICDs mimicking clinical implants. After the ICD was removed, ground-truth SSFP cine was performed. Two observers separately assessed image quality metrics and contoured the cine images to return cardiac volumes and ejection fractions. Nine patients with an ICD were also scanned with the GRE cine protocol before contrast administration; data were contoured by two observers and analyzed for interobserver agreement. Results: In the healthy volunteer dataset, no statistically significant differences were found when comparing volumes or ejection fractions between sequences (p > 0.05). Statistically significant differences were found when comparing right ventricular ejection fraction (RVEF) (p = 0.009) and right ventricular end-systolic volume (p = 0.029) between observers, with no other significant interobserver differences. The interobserver variability of patient left ventricular ejection fraction and RVEF data was 3–4%, with lower image quality metrics for patient scans than volunteer scans. Conclusion: GRE cine imaging in healthy volunteers with taped ICDs demonstrated good agreement with SSFP cine, but increased interobserver variability. In patients, reducing the breath-hold duration caused a decrease in image quality, with GRE cine imaging in patients with ICDs demonstrating poorer image quality and greater interobserver variability than in healthy volunteer studies. Future work is needed to improve GRE cine image quality in patients with ICDs to reduce interobserver variability and improve clinical confidence.http://www.sciencedirect.com/science/article/pii/S1097664725000559Cine imagingImplantable cardioverter-defibrillatorHigh-bandwidth gradient-echo |
| spellingShingle | Calder D. Sheagren Naseem Shadafny Terenz Escartin Maria Terricabras Christopher C. Cheung Idan Roifman Graham A. Wright Cardiac function evaluation in healthy volunteers and patients with implantable cardioverter-defibrillators using high-bandwidth spoiled gradient-echo cine Journal of Cardiovascular Magnetic Resonance Cine imaging Implantable cardioverter-defibrillator High-bandwidth gradient-echo |
| title | Cardiac function evaluation in healthy volunteers and patients with implantable cardioverter-defibrillators using high-bandwidth spoiled gradient-echo cine |
| title_full | Cardiac function evaluation in healthy volunteers and patients with implantable cardioverter-defibrillators using high-bandwidth spoiled gradient-echo cine |
| title_fullStr | Cardiac function evaluation in healthy volunteers and patients with implantable cardioverter-defibrillators using high-bandwidth spoiled gradient-echo cine |
| title_full_unstemmed | Cardiac function evaluation in healthy volunteers and patients with implantable cardioverter-defibrillators using high-bandwidth spoiled gradient-echo cine |
| title_short | Cardiac function evaluation in healthy volunteers and patients with implantable cardioverter-defibrillators using high-bandwidth spoiled gradient-echo cine |
| title_sort | cardiac function evaluation in healthy volunteers and patients with implantable cardioverter defibrillators using high bandwidth spoiled gradient echo cine |
| topic | Cine imaging Implantable cardioverter-defibrillator High-bandwidth gradient-echo |
| url | http://www.sciencedirect.com/science/article/pii/S1097664725000559 |
| work_keys_str_mv | AT calderdsheagren cardiacfunctionevaluationinhealthyvolunteersandpatientswithimplantablecardioverterdefibrillatorsusinghighbandwidthspoiledgradientechocine AT naseemshadafny cardiacfunctionevaluationinhealthyvolunteersandpatientswithimplantablecardioverterdefibrillatorsusinghighbandwidthspoiledgradientechocine AT terenzescartin cardiacfunctionevaluationinhealthyvolunteersandpatientswithimplantablecardioverterdefibrillatorsusinghighbandwidthspoiledgradientechocine AT mariaterricabras cardiacfunctionevaluationinhealthyvolunteersandpatientswithimplantablecardioverterdefibrillatorsusinghighbandwidthspoiledgradientechocine AT christopherccheung cardiacfunctionevaluationinhealthyvolunteersandpatientswithimplantablecardioverterdefibrillatorsusinghighbandwidthspoiledgradientechocine AT idanroifman cardiacfunctionevaluationinhealthyvolunteersandpatientswithimplantablecardioverterdefibrillatorsusinghighbandwidthspoiledgradientechocine AT grahamawright cardiacfunctionevaluationinhealthyvolunteersandpatientswithimplantablecardioverterdefibrillatorsusinghighbandwidthspoiledgradientechocine |