FORMULATION AND OPTIMIZATION OF DOMPERIDONE-LOADED LIQUID SNEDDS: CHARACTERIZATION AND IN-VITRO EVALUATION
This research concentrated on developing and optimizing domperidone-loaded Self- nanoemulsifying drug delivery system (SNEDDS) to enhance solubility, stability, and availability. Domperidone (DOM), a lipophilic drug characterized by its limited solubility in water, was integrated into SNEDDS formul...
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University of Zakho
2025-07-01
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| Series: | Science Journal of University of Zakho |
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| Online Access: | http://sjuoz.uoz.edu.krd/index.php/sjuoz/article/view/1576 |
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| author | Sara Rassol Adnan Burhan Qader |
| author_facet | Sara Rassol Adnan Burhan Qader |
| author_sort | Sara Rassol |
| collection | DOAJ |
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This research concentrated on developing and optimizing domperidone-loaded Self- nanoemulsifying drug delivery system (SNEDDS) to enhance solubility, stability, and availability. Domperidone (DOM), a lipophilic drug characterized by its limited solubility in water, was integrated into SNEDDS formulations utilizing a range of oils, surfactants, and cosurfactants. Solubility studies indicated that orange oil exhibited the highest solubility for DOM at (47.94 mg/mL ± 0.085) against oils, Cremophor EL among surfactants, and Transcutol HP against cosurfactants. The solubility enhancement can be attributed to the formation of nanoemulsions, which effectively diminish particle size and enhances surface area, leading to improved dissolution and accelerated absorption. The optimization of the formulation was conducted utilizing a pseudo-ternary phase diagram, twelve successful formulations were evaluated and characterized for self-emulsification, stability, and drug release. In-vitro characterization demonstrated that F1 formula (Orange oil+ Cremophor EL+ Transcutol HP) using (2:8, oil: S.mix ratio) released DOM at rates up to 3.7 times greater than those of commercial products. The rapid emulsification times, ranging from (13.75 ± 0.528 to 32.17 ± 1.193 seconds), consistent droplet sizes, and a low PDI (0.28 ± 0.03 to 0.68 ± 0.2) have significantly improved bioavailability
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| format | Article |
| id | doaj-art-4f90fa15df09414a9afc1a9b41bbf9ed |
| institution | DOAJ |
| issn | 2663-628X 2663-6298 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | University of Zakho |
| record_format | Article |
| series | Science Journal of University of Zakho |
| spelling | doaj-art-4f90fa15df09414a9afc1a9b41bbf9ed2025-08-20T03:08:40ZengUniversity of ZakhoScience Journal of University of Zakho2663-628X2663-62982025-07-0113310.25271/sjuoz.2025.13.3.1576FORMULATION AND OPTIMIZATION OF DOMPERIDONE-LOADED LIQUID SNEDDS: CHARACTERIZATION AND IN-VITRO EVALUATIONSara Rassol0Adnan Burhan Qader 1Department of Pharmaceutics, College of Pharmacy, Hawler Medical University, Erbil, Kurdistan Region, IraqDepartment of Pharmaceutics, College of Pharmacy, Hawler Medical University, Erbil, Kurdistan Region, Iraq This research concentrated on developing and optimizing domperidone-loaded Self- nanoemulsifying drug delivery system (SNEDDS) to enhance solubility, stability, and availability. Domperidone (DOM), a lipophilic drug characterized by its limited solubility in water, was integrated into SNEDDS formulations utilizing a range of oils, surfactants, and cosurfactants. Solubility studies indicated that orange oil exhibited the highest solubility for DOM at (47.94 mg/mL ± 0.085) against oils, Cremophor EL among surfactants, and Transcutol HP against cosurfactants. The solubility enhancement can be attributed to the formation of nanoemulsions, which effectively diminish particle size and enhances surface area, leading to improved dissolution and accelerated absorption. The optimization of the formulation was conducted utilizing a pseudo-ternary phase diagram, twelve successful formulations were evaluated and characterized for self-emulsification, stability, and drug release. In-vitro characterization demonstrated that F1 formula (Orange oil+ Cremophor EL+ Transcutol HP) using (2:8, oil: S.mix ratio) released DOM at rates up to 3.7 times greater than those of commercial products. The rapid emulsification times, ranging from (13.75 ± 0.528 to 32.17 ± 1.193 seconds), consistent droplet sizes, and a low PDI (0.28 ± 0.03 to 0.68 ± 0.2) have significantly improved bioavailability http://sjuoz.uoz.edu.krd/index.php/sjuoz/article/view/1576AvailabilityDomperidone (DOMSelf-Nanoemulsifying Drug Delivery SystemSolubility Study |
| spellingShingle | Sara Rassol Adnan Burhan Qader FORMULATION AND OPTIMIZATION OF DOMPERIDONE-LOADED LIQUID SNEDDS: CHARACTERIZATION AND IN-VITRO EVALUATION Science Journal of University of Zakho Availability Domperidone (DOM Self-Nanoemulsifying Drug Delivery System Solubility Study |
| title | FORMULATION AND OPTIMIZATION OF DOMPERIDONE-LOADED LIQUID SNEDDS: CHARACTERIZATION AND IN-VITRO EVALUATION |
| title_full | FORMULATION AND OPTIMIZATION OF DOMPERIDONE-LOADED LIQUID SNEDDS: CHARACTERIZATION AND IN-VITRO EVALUATION |
| title_fullStr | FORMULATION AND OPTIMIZATION OF DOMPERIDONE-LOADED LIQUID SNEDDS: CHARACTERIZATION AND IN-VITRO EVALUATION |
| title_full_unstemmed | FORMULATION AND OPTIMIZATION OF DOMPERIDONE-LOADED LIQUID SNEDDS: CHARACTERIZATION AND IN-VITRO EVALUATION |
| title_short | FORMULATION AND OPTIMIZATION OF DOMPERIDONE-LOADED LIQUID SNEDDS: CHARACTERIZATION AND IN-VITRO EVALUATION |
| title_sort | formulation and optimization of domperidone loaded liquid snedds characterization and in vitro evaluation |
| topic | Availability Domperidone (DOM Self-Nanoemulsifying Drug Delivery System Solubility Study |
| url | http://sjuoz.uoz.edu.krd/index.php/sjuoz/article/view/1576 |
| work_keys_str_mv | AT sararassol formulationandoptimizationofdomperidoneloadedliquidsneddscharacterizationandinvitroevaluation AT adnanburhanqader formulationandoptimizationofdomperidoneloadedliquidsneddscharacterizationandinvitroevaluation |