The potency-ratio of ciprofol and propofol under procedural sedation and anesthesia for outpatient hysteroscopy during cervical dilation: a study using up-and-down sequential allocation method
Abstract Background Ciprofol(HSK3486) is a novel 2,6-disubstituted phenol derivate, a short-acting intravenous sedative, which has similar efficacy characteristics as propofol with less incidence of side effect. Both ciprofol and propofol are often used in outpatient hysteroscopic surgery for sedati...
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2024-11-01
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| Series: | BMC Anesthesiology |
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| Online Access: | https://doi.org/10.1186/s12871-024-02793-2 |
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| author | Lin Jin Cui-cui Jiao Xiao-ping Chen Li-hong Sun Yu Zhang Xin-zhong Cheng Jin-zhong Wang Xiao-wei Qian |
| author_facet | Lin Jin Cui-cui Jiao Xiao-ping Chen Li-hong Sun Yu Zhang Xin-zhong Cheng Jin-zhong Wang Xiao-wei Qian |
| author_sort | Lin Jin |
| collection | DOAJ |
| description | Abstract Background Ciprofol(HSK3486) is a novel 2,6-disubstituted phenol derivate, a short-acting intravenous sedative, which has similar efficacy characteristics as propofol with less incidence of side effect. Both ciprofol and propofol are often used in outpatient hysteroscopic surgery for sedation. However, the relative potency of these two drugs has not been fully determined in this context. Objective Our study aimed to investigate the potency-ratio of ciprofol and propofol under procedural sedation and anesthesia in restraining reaction of outpatient hysteroscopy dilatation. Methods The ED50 (effective dose in 50% of subjects) value for ciprofol and propofol were calculated by Up-and-Down Sequential Allocation Method. 60 healthy patients undergoing daytime hysteroscopy were randomly divided into two groups, which were intravenously injected with ciprofol at an initial dose of 0.4 mg/kg (group C) or propofol at an initial dose of 2 mg/kg (group P) at 2 min after intravenous injection of sufentanil 0.15ug/kg. A successful response is defined as the absence of patient movement in the case of cervical dilation. Conversely, the presence of patient movement is defined as failure. After successful or failed responses, each follow-up patient in the corresponding group was reduced or increased with propofol 0.5 mg/kg or ciprofol 0.1 mg/kg, respectively. Results The estimated ED50 value for ciprofol and propofol in restraining reaction of hysteroscopy dilatation was 0.444 mg/kg (95% CI, 0.385-0.503 mg/kg) and 1.985 mg/kg (95% CI, 1.801–2.170 mg/kg), respectively. The incidence of respiratory depression, hypoxemia and injection pain in ciprofol was significantly lower than those in propofol. Conclusion The ED50 of ciprofol and propofol in preventing hysteroscopy dilatation reaction was 0.444 mg/kg (95% CI, 0.385-0.503 mg/kg) and 1.985 mg/kg (95% CI, 1.801–2.170 mg/kg) for outpatient hysteroscopy. The potency-ratio of ciprofol and propofol observed in our study was 1.0:4.5(95%CI,1:3.9-1:5.1). Trial registration The study was registered at Chinese Clinical Trial Registry http//www.chictr.org.cn/ (Registration date19/11/22 Trial ID ChiCTR2200065954). |
| format | Article |
| id | doaj-art-4f8face872404ff2aebd084e2eddbddf |
| institution | OA Journals |
| issn | 1471-2253 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | BMC |
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| series | BMC Anesthesiology |
| spelling | doaj-art-4f8face872404ff2aebd084e2eddbddf2025-08-20T02:38:35ZengBMCBMC Anesthesiology1471-22532024-11-012411810.1186/s12871-024-02793-2The potency-ratio of ciprofol and propofol under procedural sedation and anesthesia for outpatient hysteroscopy during cervical dilation: a study using up-and-down sequential allocation methodLin Jin0Cui-cui Jiao1Xiao-ping Chen2Li-hong Sun3Yu Zhang4Xin-zhong Cheng5Jin-zhong Wang6Xiao-wei Qian7Department of Anesthesiology, Women’s Hospital, Zhejiang University School of MedicineDepartment of Anesthesiology, Women’s Hospital, Zhejiang University School of MedicineDepartment of Anesthesiology, Women’s Hospital, Zhejiang University School of MedicineDepartment of Anesthesiology, Women’s Hospital, Zhejiang University School of MedicineDepartment of Anesthesiology, Women’s Hospital, Zhejiang University School of MedicineDepartment of Anesthesiology, Women’s Hospital, Zhejiang University School of MedicineDepartment of Anesthesiology, Hangzhou Ninth People’s HospitalDepartment of Anesthesiology, Women’s Hospital, Zhejiang University School of MedicineAbstract Background Ciprofol(HSK3486) is a novel 2,6-disubstituted phenol derivate, a short-acting intravenous sedative, which has similar efficacy characteristics as propofol with less incidence of side effect. Both ciprofol and propofol are often used in outpatient hysteroscopic surgery for sedation. However, the relative potency of these two drugs has not been fully determined in this context. Objective Our study aimed to investigate the potency-ratio of ciprofol and propofol under procedural sedation and anesthesia in restraining reaction of outpatient hysteroscopy dilatation. Methods The ED50 (effective dose in 50% of subjects) value for ciprofol and propofol were calculated by Up-and-Down Sequential Allocation Method. 60 healthy patients undergoing daytime hysteroscopy were randomly divided into two groups, which were intravenously injected with ciprofol at an initial dose of 0.4 mg/kg (group C) or propofol at an initial dose of 2 mg/kg (group P) at 2 min after intravenous injection of sufentanil 0.15ug/kg. A successful response is defined as the absence of patient movement in the case of cervical dilation. Conversely, the presence of patient movement is defined as failure. After successful or failed responses, each follow-up patient in the corresponding group was reduced or increased with propofol 0.5 mg/kg or ciprofol 0.1 mg/kg, respectively. Results The estimated ED50 value for ciprofol and propofol in restraining reaction of hysteroscopy dilatation was 0.444 mg/kg (95% CI, 0.385-0.503 mg/kg) and 1.985 mg/kg (95% CI, 1.801–2.170 mg/kg), respectively. The incidence of respiratory depression, hypoxemia and injection pain in ciprofol was significantly lower than those in propofol. Conclusion The ED50 of ciprofol and propofol in preventing hysteroscopy dilatation reaction was 0.444 mg/kg (95% CI, 0.385-0.503 mg/kg) and 1.985 mg/kg (95% CI, 1.801–2.170 mg/kg) for outpatient hysteroscopy. The potency-ratio of ciprofol and propofol observed in our study was 1.0:4.5(95%CI,1:3.9-1:5.1). Trial registration The study was registered at Chinese Clinical Trial Registry http//www.chictr.org.cn/ (Registration date19/11/22 Trial ID ChiCTR2200065954).https://doi.org/10.1186/s12871-024-02793-2CiprofolPropofolHysteroscopyED50Anethesia |
| spellingShingle | Lin Jin Cui-cui Jiao Xiao-ping Chen Li-hong Sun Yu Zhang Xin-zhong Cheng Jin-zhong Wang Xiao-wei Qian The potency-ratio of ciprofol and propofol under procedural sedation and anesthesia for outpatient hysteroscopy during cervical dilation: a study using up-and-down sequential allocation method BMC Anesthesiology Ciprofol Propofol Hysteroscopy ED50 Anethesia |
| title | The potency-ratio of ciprofol and propofol under procedural sedation and anesthesia for outpatient hysteroscopy during cervical dilation: a study using up-and-down sequential allocation method |
| title_full | The potency-ratio of ciprofol and propofol under procedural sedation and anesthesia for outpatient hysteroscopy during cervical dilation: a study using up-and-down sequential allocation method |
| title_fullStr | The potency-ratio of ciprofol and propofol under procedural sedation and anesthesia for outpatient hysteroscopy during cervical dilation: a study using up-and-down sequential allocation method |
| title_full_unstemmed | The potency-ratio of ciprofol and propofol under procedural sedation and anesthesia for outpatient hysteroscopy during cervical dilation: a study using up-and-down sequential allocation method |
| title_short | The potency-ratio of ciprofol and propofol under procedural sedation and anesthesia for outpatient hysteroscopy during cervical dilation: a study using up-and-down sequential allocation method |
| title_sort | potency ratio of ciprofol and propofol under procedural sedation and anesthesia for outpatient hysteroscopy during cervical dilation a study using up and down sequential allocation method |
| topic | Ciprofol Propofol Hysteroscopy ED50 Anethesia |
| url | https://doi.org/10.1186/s12871-024-02793-2 |
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