Mitochondrial DNA polymorphisms in individuals died from sudden cardiac death
Aim. To identify associations of mtDNA polymorphisms with sudden cardiac death.Materials and Methods. DNA was isolated from the cardiac tissue excised during the autopsy from individuals who died from sudden cardiac death (n = 260). The frequencies of the most common European mtDNA haplogroups (H, U...
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| Format: | Article |
| Language: | Russian |
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Kemerovo State Medical University
2019-12-01
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| Series: | Фундаментальная и клиническая медицина |
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| Online Access: | https://fcm.kemsmu.ru/jour/article/view/191 |
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| author | M. V. Golubenko A. V. Tsepokina R. R. Salakhov V. N. Maksimov A. A. Gurazheva B. A. Tkhorenko A. V. Ponasenko |
| author_facet | M. V. Golubenko A. V. Tsepokina R. R. Salakhov V. N. Maksimov A. A. Gurazheva B. A. Tkhorenko A. V. Ponasenko |
| author_sort | M. V. Golubenko |
| collection | DOAJ |
| description | Aim. To identify associations of mtDNA polymorphisms with sudden cardiac death.Materials and Methods. DNA was isolated from the cardiac tissue excised during the autopsy from individuals who died from sudden cardiac death (n = 260). The frequencies of the most common European mtDNA haplogroups (H, U, T and J) were determined using restriction fragment length polymorphism analysis. In addition, we performed a comparative analysis using previously published data on mtDNA polymorphisms in the West Siberian population.Results. The distribution of mtDNA haplogroups in the patients who died from sudden cardiac death was similar as in the general population: 40% for haplogroup H, 23% for haplogroup U, 12% for haplogroup T and 6.5% for haplogroup J. We found no significant differences regarding the frequency of mtDNA haplogroups in individuals who died from sudden cardiac death and the population level.Conclusion. We discovered no associations of H, U, T, and J mtDNA haplogroups with sudden cardiac death. These results indicate the necessity of a detailed analysis of mitochondrial genome to determine mtDNA variants associated with sudden cardiac death. |
| format | Article |
| id | doaj-art-4f8cb942cfec4e8cafc14922249714de |
| institution | DOAJ |
| issn | 2500-0764 2542-0941 |
| language | Russian |
| publishDate | 2019-12-01 |
| publisher | Kemerovo State Medical University |
| record_format | Article |
| series | Фундаментальная и клиническая медицина |
| spelling | doaj-art-4f8cb942cfec4e8cafc14922249714de2025-08-20T03:19:57ZrusKemerovo State Medical UniversityФундаментальная и клиническая медицина2500-07642542-09412019-12-0144646910.23946/2500-0764-2019-4-4-64-69177Mitochondrial DNA polymorphisms in individuals died from sudden cardiac deathM. V. Golubenko0A. V. Tsepokina1R. R. Salakhov2V. N. Maksimov3A. A. Gurazheva4B. A. Tkhorenko5A. V. Ponasenko6Research Institute for Complex Issues of Cardiovascular Diseases; Research Institute of Medical GeneticsResearch Institute for Complex Issues of Cardiovascular DiseasesResearch Institute of Medical GeneticsResearch Institute of Therapy and Preventive Medicine within the Research Institute of Cytology and GeneticsResearch Institute of Therapy and Preventive Medicine within the Research Institute of Cytology and GeneticsResearch Institute for Complex Issues of Cardiovascular DiseasesResearch Institute for Complex Issues of Cardiovascular DiseasesAim. To identify associations of mtDNA polymorphisms with sudden cardiac death.Materials and Methods. DNA was isolated from the cardiac tissue excised during the autopsy from individuals who died from sudden cardiac death (n = 260). The frequencies of the most common European mtDNA haplogroups (H, U, T and J) were determined using restriction fragment length polymorphism analysis. In addition, we performed a comparative analysis using previously published data on mtDNA polymorphisms in the West Siberian population.Results. The distribution of mtDNA haplogroups in the patients who died from sudden cardiac death was similar as in the general population: 40% for haplogroup H, 23% for haplogroup U, 12% for haplogroup T and 6.5% for haplogroup J. We found no significant differences regarding the frequency of mtDNA haplogroups in individuals who died from sudden cardiac death and the population level.Conclusion. We discovered no associations of H, U, T, and J mtDNA haplogroups with sudden cardiac death. These results indicate the necessity of a detailed analysis of mitochondrial genome to determine mtDNA variants associated with sudden cardiac death.https://fcm.kemsmu.ru/jour/article/view/191sudden cardiac deathmitochondrial dnagenetic polymorphism |
| spellingShingle | M. V. Golubenko A. V. Tsepokina R. R. Salakhov V. N. Maksimov A. A. Gurazheva B. A. Tkhorenko A. V. Ponasenko Mitochondrial DNA polymorphisms in individuals died from sudden cardiac death Фундаментальная и клиническая медицина sudden cardiac death mitochondrial dna genetic polymorphism |
| title | Mitochondrial DNA polymorphisms in individuals died from sudden cardiac death |
| title_full | Mitochondrial DNA polymorphisms in individuals died from sudden cardiac death |
| title_fullStr | Mitochondrial DNA polymorphisms in individuals died from sudden cardiac death |
| title_full_unstemmed | Mitochondrial DNA polymorphisms in individuals died from sudden cardiac death |
| title_short | Mitochondrial DNA polymorphisms in individuals died from sudden cardiac death |
| title_sort | mitochondrial dna polymorphisms in individuals died from sudden cardiac death |
| topic | sudden cardiac death mitochondrial dna genetic polymorphism |
| url | https://fcm.kemsmu.ru/jour/article/view/191 |
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