New Insights on Post-COVID-19 Pulmonary Fibrosis: Risk Factors and Clinical Correlations

New Insights on Post-COVID-19 Pulmonary Fibrosis: Risk Factors and Clinical Correlations

Background: The coronavirus disease 2019 (COVID-19) effect on the lungs ranges from an asymptomatic infection to a critical illness with acute respiratory failure, acute respiratory distress syndrome (ARDS), septic shock, or multiorgan failure. Pulmonary fibrosis, as a short-term or long-term compli...

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Main Authors: Nasir Abdelrafie, Lienda Bashier Eltayeb, Habab Merghani Yassin, Dalia G Hamouda, Alaa Eltayeb Omer, Abeer Abd Alla Elhassan Babekir, Alwaleed Khalid Al Balushi, Juhaina Abdullah Al Battashi, Maha Hadid Al Alawiya, Maram Yaqoob Al Zadjali, Shahd Abdullatif Al Balushi, Sirin Khasib Al Majarafi
Format: Article
Language:English
Published: International Medical Research and Development Corporation 2024-12-01
Series:International Journal of Biomedicine
Subjects:
sars-cov-2
covid-19
risk factors
pulmonary fibrosis
Online Access:http://www.ijbm.org/articles/i56/ijbm_14(4)_oa21.pdf
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Summary:Background: The coronavirus disease 2019 (COVID-19) effect on the lungs ranges from an asymptomatic infection to a critical illness with acute respiratory failure, acute respiratory distress syndrome (ARDS), septic shock, or multiorgan failure. Pulmonary fibrosis, as a short-term or long-term complication of SARS-CoV-2 infection, is a progressive and fatal sequel to COVID-19. The present study assessed the risk factors and clinical findings associated with post-COVID-19 pulmonary fibrosis. Methods and Results: This case-control study was conducted among Omani citizens and residents of Sohar State, Oman, from 01 Jan 2020 to 31 Dec 2022. The study involved 106 patients with post-COVID-19 pulmonary fibrosis (the main group) and 102 subjects who recovered from COVID-19 without pulmonary fibrosis (the control group). Advanced age, length of hospital stay, and the need for mechanical ventilation were significantly associated with post-COVID-19 pulmonary fibrosis. Moreover, the current study reported a significant elevation in total white blood cell count, serum lactate dehydrogenase, serum creatinine, and D-dimer levels among patients with pulmonary fibrosis. Conclusion: The current study demonstrated a potential association between post-COVID-19 pulmonary fibrosis and severity-associated markers of COVID-19.
ISSN:2158-0510
2158-0529

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