Reviewing prognostic factors associated with recurrence in clinically early-stage low-risk endometrial cancer
Objective: We sought to re-explore the association between well-known prognostic factors and recurrence in presumed early-stage low-risk endometrial cancer (EC). Methods: A retrospective cohort study was carried out on patients who underwent surgical treatment by the same surgeon for presumed early-...
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| Format: | Article |
| Language: | English |
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Thieme Revinter Publicações Ltda.
2022-10-01
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| Series: | Brazilian Journal of Oncology |
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| Online Access: | https://www.brazilianjournalofoncology.com.br/details/180/en-US/reviewing-prognostic-factors-associated-with-recurrence-in-clinically-early-stage-low-risk-endometrial-cancer |
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| author | Thales Paulo Batista Rafael Palmeira Santana Camilla Maria Guimarães Augusto Nivaldo Sobral Morais Maria Lídia Amaral Barbosa Ventura Artur Lício Rocha Bezerra |
| author_facet | Thales Paulo Batista Rafael Palmeira Santana Camilla Maria Guimarães Augusto Nivaldo Sobral Morais Maria Lídia Amaral Barbosa Ventura Artur Lício Rocha Bezerra |
| author_sort | Thales Paulo Batista |
| collection | DOAJ |
| description | Objective: We sought to re-explore the association between well-known prognostic factors and recurrence in presumed early-stage low-risk endometrial cancer (EC). Methods: A retrospective cohort study was carried out on patients who underwent surgical treatment by the same surgeon for presumed early-stage low-risk EC between September 2003 to August 2017. The prognostic value of well-known clinicopathological factors for diseasefree survival (DFS) was reviewed by univariate log-rank test. Results: One hundred and five patients fit the criteria for this analysis. These patients underwent total hysterectomy plus bilateral salpingo-oophorectomy with no lymph nodes dissection (10.5%) or with a sampling dissection alone (89.5%). Adjuvant therapies were applied in 52 (40.1%) of them as pelvic radiotherapy (29.5%) or chemoradiation (11.4%). Our cumulative 3y-DFS and OS were 88.1% and 97.7%, respectively. The univariate survival analysis confirmed histological grade 3 (3y-DFS of 89.9% vs. 33.3%, p=0.004), MMI ≥50% (3y-DFS of 95.2% vs. 71.3%, p=0.003), lymph node metastasis (3y-DFS of 88.3% vs. 60%; p=0.028) and more advanced pathological stages (3y-DFS of 91.2% vs. 56.3; p<0.001) as significantly associated to recurrences. Conclusion: We confirmed the association of classical prognostic factors such as high histological grade, deeper MMI, lymph node metastasis and more advanced pathological stages with disease recurrence in this cohort of patients from Northeast Brazil. Further efforts are needed to avoid overtreatment in patients with low risk of relapses. |
| format | Article |
| id | doaj-art-4f8236decc7249568c996d334ed486d8 |
| institution | OA Journals |
| issn | 2526-8732 |
| language | English |
| publishDate | 2022-10-01 |
| publisher | Thieme Revinter Publicações Ltda. |
| record_format | Article |
| series | Brazilian Journal of Oncology |
| spelling | doaj-art-4f8236decc7249568c996d334ed486d82025-08-20T02:05:39ZengThieme Revinter Publicações Ltda.Brazilian Journal of Oncology2526-87322022-10-01180010.5935/2526-8732.20220244Reviewing prognostic factors associated with recurrence in clinically early-stage low-risk endometrial cancerThales Paulo Batista0https://orcid.org/0000-0001-5320-3205Rafael Palmeira Santana1Camilla Maria Guimarães Augusto2Nivaldo Sobral Morais3Maria Lídia Amaral Barbosa Ventura4Artur Lício Rocha Bezerra5Instituto de Medicina Integral professor Fernando Figueira (IMIP), Department of Surgery/Oncology - Recife - Pernambuco - BrazilInstituto de Medicina Integral professor Fernando Figueira (IMIP), Faculdade Pernambucana de Saúde - Recife - Pernambuco - BrazilInstituto de Medicina Integral professor Fernando Figueira (IMIP), Faculdade Pernambucana de Saúde - Recife - Pernambuco - BrazilInstituto de Medicina Integral professor Fernando Figueira (IMIP), Faculdade Pernambucana de Saúde - Recife - Pernambuco - BrazilInstituto de Medicina Integral professor Fernando Figueira (IMIP), Faculdade Pernambucana de Saúde - Recife - Pernambuco - BrazilInstituto de Medicina Integral professor Fernando Figueira (IMIP), Faculdade Pernambucana de Saúde - Recife - Pernambuco - BrazilObjective: We sought to re-explore the association between well-known prognostic factors and recurrence in presumed early-stage low-risk endometrial cancer (EC). Methods: A retrospective cohort study was carried out on patients who underwent surgical treatment by the same surgeon for presumed early-stage low-risk EC between September 2003 to August 2017. The prognostic value of well-known clinicopathological factors for diseasefree survival (DFS) was reviewed by univariate log-rank test. Results: One hundred and five patients fit the criteria for this analysis. These patients underwent total hysterectomy plus bilateral salpingo-oophorectomy with no lymph nodes dissection (10.5%) or with a sampling dissection alone (89.5%). Adjuvant therapies were applied in 52 (40.1%) of them as pelvic radiotherapy (29.5%) or chemoradiation (11.4%). Our cumulative 3y-DFS and OS were 88.1% and 97.7%, respectively. The univariate survival analysis confirmed histological grade 3 (3y-DFS of 89.9% vs. 33.3%, p=0.004), MMI ≥50% (3y-DFS of 95.2% vs. 71.3%, p=0.003), lymph node metastasis (3y-DFS of 88.3% vs. 60%; p=0.028) and more advanced pathological stages (3y-DFS of 91.2% vs. 56.3; p<0.001) as significantly associated to recurrences. Conclusion: We confirmed the association of classical prognostic factors such as high histological grade, deeper MMI, lymph node metastasis and more advanced pathological stages with disease recurrence in this cohort of patients from Northeast Brazil. Further efforts are needed to avoid overtreatment in patients with low risk of relapses.https://www.brazilianjournalofoncology.com.br/details/180/en-US/reviewing-prognostic-factors-associated-with-recurrence-in-clinically-early-stage-low-risk-endometrial-cancerendometrial neoplasmprognosissurvival analysisdisease-free survivallocoregional neoplasm recurrences |
| spellingShingle | Thales Paulo Batista Rafael Palmeira Santana Camilla Maria Guimarães Augusto Nivaldo Sobral Morais Maria Lídia Amaral Barbosa Ventura Artur Lício Rocha Bezerra Reviewing prognostic factors associated with recurrence in clinically early-stage low-risk endometrial cancer Brazilian Journal of Oncology endometrial neoplasm prognosis survival analysis disease-free survival locoregional neoplasm recurrences |
| title | Reviewing prognostic factors associated with recurrence in clinically early-stage low-risk endometrial cancer |
| title_full | Reviewing prognostic factors associated with recurrence in clinically early-stage low-risk endometrial cancer |
| title_fullStr | Reviewing prognostic factors associated with recurrence in clinically early-stage low-risk endometrial cancer |
| title_full_unstemmed | Reviewing prognostic factors associated with recurrence in clinically early-stage low-risk endometrial cancer |
| title_short | Reviewing prognostic factors associated with recurrence in clinically early-stage low-risk endometrial cancer |
| title_sort | reviewing prognostic factors associated with recurrence in clinically early stage low risk endometrial cancer |
| topic | endometrial neoplasm prognosis survival analysis disease-free survival locoregional neoplasm recurrences |
| url | https://www.brazilianjournalofoncology.com.br/details/180/en-US/reviewing-prognostic-factors-associated-with-recurrence-in-clinically-early-stage-low-risk-endometrial-cancer |
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