Malignant Transformation of an Ovarian Endometrioma during Endometriosis Treatment: A Case Report

Dienogest (DNG) is considered to be effective against ovarian endometrioma (OMA). We report a rare case of OMA transformation to ovarian cancer during long-term endometriosis treatment with a periodic administration of a gonadotropin-releasing hormone agonist (Gn-RH agonist) and DNG. The patient was...

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Main Authors: Hiroaki Takagi, Emi Takata, Jinichi Sakamoto, Satoko Fujita, Masahiro Takakura, Toshiyuki Sasagawa
Format: Article
Language:English
Published: Wiley 2018-01-01
Series:Case Reports in Obstetrics and Gynecology
Online Access:http://dx.doi.org/10.1155/2018/6210172
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author Hiroaki Takagi
Emi Takata
Jinichi Sakamoto
Satoko Fujita
Masahiro Takakura
Toshiyuki Sasagawa
author_facet Hiroaki Takagi
Emi Takata
Jinichi Sakamoto
Satoko Fujita
Masahiro Takakura
Toshiyuki Sasagawa
author_sort Hiroaki Takagi
collection DOAJ
description Dienogest (DNG) is considered to be effective against ovarian endometrioma (OMA). We report a rare case of OMA transformation to ovarian cancer during long-term endometriosis treatment with a periodic administration of a gonadotropin-releasing hormone agonist (Gn-RH agonist) and DNG. The patient was a 41-year-old Japanese woman. OMA and adenomyosis of the uterus were revealed via computed tomography. Consequently, she underwent conservative treatment without undergoing surgery because her overall status was poor. She received cyclic therapy (Gn-RH agonist and DNG) for approximately eight years. However, she reported lumbago and underwent close medical examination at our hospital after about eight years of treatment. Under the suspicion of malignant transformation, she underwent surgery. The pathological diagnosis was clear cell carcinoma of the right ovary (stage 2B). After surgery, she received six courses of chemotherapy (conventional TC). No evidence of disease was observed after chemotherapy. Our findings suggest that malignant transformation of OMA can occur during DNG treatment. Since the delayed detection of ovarian cancer greatly affects the prognosis, women older than 40 with OMA are encouraged to undergo regular check-ups every few months.
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series Case Reports in Obstetrics and Gynecology
spelling doaj-art-4f7a72c2489c491f95accf78cbc8907f2025-08-20T03:20:19ZengWileyCase Reports in Obstetrics and Gynecology2090-66842090-66922018-01-01201810.1155/2018/62101726210172Malignant Transformation of an Ovarian Endometrioma during Endometriosis Treatment: A Case ReportHiroaki Takagi0Emi Takata1Jinichi Sakamoto2Satoko Fujita3Masahiro Takakura4Toshiyuki Sasagawa5Department of Obstetrics and Gynecology, Kanazawa Medical University, School of Medicine, JapanDepartment of Obstetrics and Gynecology, Kanazawa Medical University, School of Medicine, JapanDepartment of Obstetrics and Gynecology, Kanazawa Medical University, School of Medicine, JapanDepartment of Obstetrics and Gynecology, Kanazawa Medical University, School of Medicine, JapanDepartment of Obstetrics and Gynecology, Kanazawa Medical University, School of Medicine, JapanDepartment of Obstetrics and Gynecology, Kanazawa Medical University, School of Medicine, JapanDienogest (DNG) is considered to be effective against ovarian endometrioma (OMA). We report a rare case of OMA transformation to ovarian cancer during long-term endometriosis treatment with a periodic administration of a gonadotropin-releasing hormone agonist (Gn-RH agonist) and DNG. The patient was a 41-year-old Japanese woman. OMA and adenomyosis of the uterus were revealed via computed tomography. Consequently, she underwent conservative treatment without undergoing surgery because her overall status was poor. She received cyclic therapy (Gn-RH agonist and DNG) for approximately eight years. However, she reported lumbago and underwent close medical examination at our hospital after about eight years of treatment. Under the suspicion of malignant transformation, she underwent surgery. The pathological diagnosis was clear cell carcinoma of the right ovary (stage 2B). After surgery, she received six courses of chemotherapy (conventional TC). No evidence of disease was observed after chemotherapy. Our findings suggest that malignant transformation of OMA can occur during DNG treatment. Since the delayed detection of ovarian cancer greatly affects the prognosis, women older than 40 with OMA are encouraged to undergo regular check-ups every few months.http://dx.doi.org/10.1155/2018/6210172
spellingShingle Hiroaki Takagi
Emi Takata
Jinichi Sakamoto
Satoko Fujita
Masahiro Takakura
Toshiyuki Sasagawa
Malignant Transformation of an Ovarian Endometrioma during Endometriosis Treatment: A Case Report
Case Reports in Obstetrics and Gynecology
title Malignant Transformation of an Ovarian Endometrioma during Endometriosis Treatment: A Case Report
title_full Malignant Transformation of an Ovarian Endometrioma during Endometriosis Treatment: A Case Report
title_fullStr Malignant Transformation of an Ovarian Endometrioma during Endometriosis Treatment: A Case Report
title_full_unstemmed Malignant Transformation of an Ovarian Endometrioma during Endometriosis Treatment: A Case Report
title_short Malignant Transformation of an Ovarian Endometrioma during Endometriosis Treatment: A Case Report
title_sort malignant transformation of an ovarian endometrioma during endometriosis treatment a case report
url http://dx.doi.org/10.1155/2018/6210172
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AT emitakata malignanttransformationofanovarianendometriomaduringendometriosistreatmentacasereport
AT jinichisakamoto malignanttransformationofanovarianendometriomaduringendometriosistreatmentacasereport
AT satokofujita malignanttransformationofanovarianendometriomaduringendometriosistreatmentacasereport
AT masahirotakakura malignanttransformationofanovarianendometriomaduringendometriosistreatmentacasereport
AT toshiyukisasagawa malignanttransformationofanovarianendometriomaduringendometriosistreatmentacasereport