Immunosuppression and HIV Infection: A Therapeutic Challenge
The optimal use of biological response modifiers (BRMs) in human immunodeficiency virus (HIV)-related disease depends on knowledge of the molecular basis of the immune deficiencies and dysregulations that occur during the course of the infection; evidence for the role of viral products and cytokines...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
1992-01-01
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| Series: | Canadian Journal of Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/1992/740587 |
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| Summary: | The optimal use of biological response modifiers
(BRMs) in human immunodeficiency virus (HIV)-related disease depends on knowledge of the molecular
basis of the immune deficiencies and dysregulations that occur during the course of the infection; evidence
for the role of viral products and cytokines in the suppression of immune function is discussed. Immunebased
therapies are currently being explored alone and in combination with drugs targeted to HIV and
associated opportunistic infections and malignancies. These therapies include hematopoietic growth
factors for the management of drug toxicities, cytokines, antigen- and cell-based therapies, and synthetic
immunomodulators. The entry of additional BRMs into clinical trials for HIV-disease can be facilitated by
well-designed preclinical studies that address special problems related to the disease. including the need
for concomitant therapy for the spectrum of disease manifestations encountered. |
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| ISSN: | 1180-2332 |