Plasmolipin deficiency is essential for HUVECs survival under hypoxic conditions

Plasmolipin deficiency is essential for HUVECs survival under hypoxic conditions

Abstract This study aims to explore the molecules that affect the survival of Human Umbilical Vein Endothelial Cells (HUVECs) under hypoxia and their mechanisms of action. In hypoxia, plasmolipin (PLLP) was identified through the screening of CRISPR/Cas9 and small guide RNA (sgRNA) library. Function...

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Bibliographic Details
Main Authors: Yanghua Li, Weiling Man, Xiang Li, Xiaojie Wu, Yumeng Cui, Shiyun Chen, Xianhong Li, Yanli Lin, Lihe Jiang, Youliang Wang
Format: Article
Language:English
Published: Nature Publishing Group 2025-05-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-025-02526-5
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