Fpa (YlaN) is an iron(II) binding protein that functions to relieve Fur-mediated repression of gene expression in Staphylococcus aureus

Fpa (YlaN) is an iron(II) binding protein that functions to relieve Fur-mediated repression of gene expression in Staphylococcus aureus

ABSTRACT Iron (Fe) is a trace nutrient required by nearly all organisms. As a result of the demand for Fe and the toxicity of non-chelated cytosolic ionic Fe, regulatory systems have evolved to tightly balance Fe acquisition and usage while limiting overload. In most bacteria, including the mammalia...

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Main Authors: Jeffrey M. Boyd, Kylie Ryan Kaler, Karla Esquilín-Lebrón, Ashley Pall, Courtney J. Campbell, Mary E. Foley, Gustavo Rios-Delgado, Emilee M. Mustor, Timothy G. Stephens, Hannah Bovermann, Todd M. Greco, Ileana M. Cristea, Valerie J. Carabetta, William N. Beavers, Debashish Bhattacharya, Eric P. Skaar, Lindsey N. Shaw, Timothy L. Stemmler
Format: Article
Language:English
Published: American Society for Microbiology 2024-11-01
Series:mBio
Subjects:
iron
sulfur
Fur
Staphylococcus aureus
YlaN
Fpa
Online Access:https://journals.asm.org/doi/10.1128/mbio.02310-24
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