Type I MET inhibitors cooperate with PD-1 blockade to promote rejection of hepatocellular carcinoma

Type I MET inhibitors cooperate with PD-1 blockade to promote rejection of hepatocellular carcinoma

Blockade of the immune checkpoints programmed death-1 (PD-1) and cytotoxic lymphocyte antigen 4 has improved outcomes for patients with hepatocellular carcinoma (HCC), yet most still fail to achieve objective clinical benefit. MET plays key roles in both HCC tumorigenesis and immunosuppressive condi...

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Bibliographic Details
Main Authors: Michael A Curran, Joanna Schmidt, Ahmed O Kaseb, Arthur Liu, Madeline Steiner, Ricardo DeAzevedo, Broderick X Turner, Sherwin Newton, Rachel Fleming, Angelica Tolentino
Format: Article
Language:English
Published: BMJ Publishing Group 2024-10-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/12/10/e009690.full
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