Quantitative imaging outperforms No-reflow in predicting functional outcomes in a translational stroke model

Quantitative imaging outperforms No-reflow in predicting functional outcomes in a translational stroke model

Microvascular dysfunction and no-reflow are considered a major cause of secondary damage despite revascularization in acute ischemic stroke (AIS), ultimately affecting patient outcomes. We used quantitative PET-MRI imaging to characterize early microvascular damages in a preclinical non-human primat...

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Bibliographic Details
Main Authors: Justine Debatisse, Lucie Chalet, Omer Faruk Eker, Tae-Hee Cho, Guillaume Becker, Océane Wateau, Marlène Wiart, Nicolas Costes, Inés Mérida, Christelle Léon, Jean-Baptiste Langlois, Sophie Lancelot, François Lux, Timothé Boutelier, Norbert Nighoghossian, Laura Mechtouff, Emmanuelle Canet-Soulas
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Neurotherapeutics
Subjects:
Acute ischemic stroke
Thrombectomy
No-reflow
PET-MRI
Blood-brain barrier
Oxygen metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S1878747925000078
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