XIAP 3′-untranslated region serves as a competitor for HMGA2 by arresting endogenous let-7a-5p in human hepatocellular carcinoma

X-linked inhibitor of apoptosis protein functions as an intrinsic regulator of apoptosis by inhibition of caspase activity and possesses a pivotal role in human cancer development and progression. A growing body of literature has demonstrated that microRNAs lead to the degradation or translational r...

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Main Authors: Wen-Yong Wu, Si-Qi Tao, Xiao-Nan Wang, Peter E Lobie, Zheng-Sheng Wu
Format: Article
Language:English
Published: SAGE Publishing 2017-07-01
Series:Tumor Biology
Online Access:https://doi.org/10.1177/1010428317719578
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author Wen-Yong Wu
Si-Qi Tao
Xiao-Nan Wang
Peter E Lobie
Zheng-Sheng Wu
author_facet Wen-Yong Wu
Si-Qi Tao
Xiao-Nan Wang
Peter E Lobie
Zheng-Sheng Wu
author_sort Wen-Yong Wu
collection DOAJ
description X-linked inhibitor of apoptosis protein functions as an intrinsic regulator of apoptosis by inhibition of caspase activity and possesses a pivotal role in human cancer development and progression. A growing body of literature has demonstrated that microRNAs lead to the degradation or translational repression of messenger RNAs by binding to the non-coding region of messenger RNA at the 3′-untranslated region. Here, we revealed that the expression of HMGA2 is upregulated with X-linked inhibitor of apoptosis protein after transfection of X-linked inhibitor of apoptosis protein 3′-untranslated region in hepatocellular carcinoma cells, suggesting that X-linked inhibitor of apoptosis protein 3′-untranslated region serves as a competitor for microRNAs and prevent the co-targeted messenger RNA, HMGA2, from being suppressed. We further identified that let-7a-5p could bind to both the X-linked inhibitor of apoptosis protein 3′-untranslated region and HMGA2 3′-untranslated region. Moreover, we demonstrated that the forced expression of X-linked inhibitor of apoptosis protein 3′-untranslated region increases the oncogenicity of hepatocellular carcinoma cells in vitro. Cell functional analyses were performed to examine the association of HMGA2 status and X-linked inhibitor of apoptosis protein 3′-untranslated region. We have also measured the functional readout of let-7a-5p and HMGA2, an assay often employed to provide substantial evidence for the effects of X-linked inhibitor of apoptosis protein 3′-untranslated region on hepatocellular carcinoma cells. In general, our findings suggest that X-linked inhibitor of apoptosis protein 3′-untranslated region serves as a competitive endogenous RNA for HMGA2 to activate hepatocellular carcinoma progression by arresting endogenous let-7a-5p.
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spelling doaj-art-4f696f9fba1d477fa5b7c91dbcc3b4dc2025-08-20T03:33:36ZengSAGE PublishingTumor Biology1423-03802017-07-013910.1177/1010428317719578XIAP 3′-untranslated region serves as a competitor for HMGA2 by arresting endogenous let-7a-5p in human hepatocellular carcinomaWen-Yong Wu0Si-Qi Tao1Xiao-Nan Wang2Peter E Lobie3Zheng-Sheng Wu4Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, ChinaDepartment of Pathology, Anhui Medical University, Hefei, ChinaLaboratory of Pathogenic Microbiology and Immunology, Anhui Medical University, Hefei, ChinaTsinghua Berkeley Shenzhen Institute, Tsinghua University Graduate School at Shenzhen, Shenzhen, ChinaDepartment of Pathology, Anhui Medical University, Hefei, ChinaX-linked inhibitor of apoptosis protein functions as an intrinsic regulator of apoptosis by inhibition of caspase activity and possesses a pivotal role in human cancer development and progression. A growing body of literature has demonstrated that microRNAs lead to the degradation or translational repression of messenger RNAs by binding to the non-coding region of messenger RNA at the 3′-untranslated region. Here, we revealed that the expression of HMGA2 is upregulated with X-linked inhibitor of apoptosis protein after transfection of X-linked inhibitor of apoptosis protein 3′-untranslated region in hepatocellular carcinoma cells, suggesting that X-linked inhibitor of apoptosis protein 3′-untranslated region serves as a competitor for microRNAs and prevent the co-targeted messenger RNA, HMGA2, from being suppressed. We further identified that let-7a-5p could bind to both the X-linked inhibitor of apoptosis protein 3′-untranslated region and HMGA2 3′-untranslated region. Moreover, we demonstrated that the forced expression of X-linked inhibitor of apoptosis protein 3′-untranslated region increases the oncogenicity of hepatocellular carcinoma cells in vitro. Cell functional analyses were performed to examine the association of HMGA2 status and X-linked inhibitor of apoptosis protein 3′-untranslated region. We have also measured the functional readout of let-7a-5p and HMGA2, an assay often employed to provide substantial evidence for the effects of X-linked inhibitor of apoptosis protein 3′-untranslated region on hepatocellular carcinoma cells. In general, our findings suggest that X-linked inhibitor of apoptosis protein 3′-untranslated region serves as a competitive endogenous RNA for HMGA2 to activate hepatocellular carcinoma progression by arresting endogenous let-7a-5p.https://doi.org/10.1177/1010428317719578
spellingShingle Wen-Yong Wu
Si-Qi Tao
Xiao-Nan Wang
Peter E Lobie
Zheng-Sheng Wu
XIAP 3′-untranslated region serves as a competitor for HMGA2 by arresting endogenous let-7a-5p in human hepatocellular carcinoma
Tumor Biology
title XIAP 3′-untranslated region serves as a competitor for HMGA2 by arresting endogenous let-7a-5p in human hepatocellular carcinoma
title_full XIAP 3′-untranslated region serves as a competitor for HMGA2 by arresting endogenous let-7a-5p in human hepatocellular carcinoma
title_fullStr XIAP 3′-untranslated region serves as a competitor for HMGA2 by arresting endogenous let-7a-5p in human hepatocellular carcinoma
title_full_unstemmed XIAP 3′-untranslated region serves as a competitor for HMGA2 by arresting endogenous let-7a-5p in human hepatocellular carcinoma
title_short XIAP 3′-untranslated region serves as a competitor for HMGA2 by arresting endogenous let-7a-5p in human hepatocellular carcinoma
title_sort xiap 3 untranslated region serves as a competitor for hmga2 by arresting endogenous let 7a 5p in human hepatocellular carcinoma
url https://doi.org/10.1177/1010428317719578
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