Polypoid Cystitis: A Retrospective Case‐Series of 112 Dogs
ABSTRACT Background Polypoid cystitis (PoC) in dogs is associated with chronic inflammatory bladder conditions and is discovered during evaluation for signs of lower urinary tract disease, or incidentally. Objective To describe PoC in dogs evaluated in an academic practice. Animals Dogs with confirm...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-05-01
|
| Series: | Journal of Veterinary Internal Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/jvim.70049 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849729597947510784 |
|---|---|
| author | Matthew P. Price Rachael Thomas Mathew Breen Allison R. Kendall Shelly L. Vaden |
| author_facet | Matthew P. Price Rachael Thomas Mathew Breen Allison R. Kendall Shelly L. Vaden |
| author_sort | Matthew P. Price |
| collection | DOAJ |
| description | ABSTRACT Background Polypoid cystitis (PoC) in dogs is associated with chronic inflammatory bladder conditions and is discovered during evaluation for signs of lower urinary tract disease, or incidentally. Objective To describe PoC in dogs evaluated in an academic practice. Animals Dogs with confirmed (n = 59) or presumptive (n = 53) PoC were evaluated between January 2004 and October 2020. Methods For this retrospective study, medical records were searched for PoC. Results The most common presenting signs of 112 dogs with PoC were hematuria (n = 42; 38%), stranguria (n = 28; 25%), and pollakiuria (n = 25; 22%). Polyps were found incidentally (n = 13; 12%). Urinary tract infection (UTI; n = 61; 54%) or urolithiasis (n = 38; 34%) was a common presumptive cause. Escherichia coli (n = 39; 53%), Enterococcus faecalis (n = 14; 19%) and Staphylococcus pseudintermedius (n = 5; 7%) were isolated from dogs with UTI. Ultrasonographic findings (n = 101) included polypoid structures (n = 44; 44%), broad‐based masses (n = 16; 26%), and bladder wall thickening (n = 25; 25%); mostly in the cranioventral bladder apex (n = 56; 80%). Of 41 specimens tested, none had evidence of the BRAF V595E mutation. Urinary tract neoplasia was not reported in any dog during follow‐up (range 1 month–8.4 years; median 8 months). Interventions included antibiotic or anti‐inflammatory administration, and surgical or cystoscopic ablation. During follow‐up, recurrent signs of lower urinary tract disease were reported in 23 (20%) dogs. Conclusions and Clinical Importance History of either UTI or urolithiasis, compatible imaging findings, and absence of detectable BRAF V595E mutation support the presumptive diagnosis of PoC in dogs. Affected dogs have a good prognosis, warranting differentiation from other urinary tract diseases. |
| format | Article |
| id | doaj-art-4f66d62da7574297aee0a6ebbfc9b819 |
| institution | DOAJ |
| issn | 0891-6640 1939-1676 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Veterinary Internal Medicine |
| spelling | doaj-art-4f66d62da7574297aee0a6ebbfc9b8192025-08-20T03:09:11ZengWileyJournal of Veterinary Internal Medicine0891-66401939-16762025-05-01393n/an/a10.1111/jvim.70049Polypoid Cystitis: A Retrospective Case‐Series of 112 DogsMatthew P. Price0Rachael Thomas1Mathew Breen2Allison R. Kendall3Shelly L. Vaden4Department of Clinical Sciences North Carolina State University, North Carolina State Veterinary Hospital Raleigh North Carolina USADepartment of Molecular Biomedical Sciences North Carolina State University at Raleigh Raleigh North Carolina USADepartment of Molecular Biomedical Sciences North Carolina State University at Raleigh Raleigh North Carolina USANorth Carolina State University Raleigh North Carolina USADepartment of Clinical Sciences North Carolina State University, North Carolina State Veterinary Hospital Raleigh North Carolina USAABSTRACT Background Polypoid cystitis (PoC) in dogs is associated with chronic inflammatory bladder conditions and is discovered during evaluation for signs of lower urinary tract disease, or incidentally. Objective To describe PoC in dogs evaluated in an academic practice. Animals Dogs with confirmed (n = 59) or presumptive (n = 53) PoC were evaluated between January 2004 and October 2020. Methods For this retrospective study, medical records were searched for PoC. Results The most common presenting signs of 112 dogs with PoC were hematuria (n = 42; 38%), stranguria (n = 28; 25%), and pollakiuria (n = 25; 22%). Polyps were found incidentally (n = 13; 12%). Urinary tract infection (UTI; n = 61; 54%) or urolithiasis (n = 38; 34%) was a common presumptive cause. Escherichia coli (n = 39; 53%), Enterococcus faecalis (n = 14; 19%) and Staphylococcus pseudintermedius (n = 5; 7%) were isolated from dogs with UTI. Ultrasonographic findings (n = 101) included polypoid structures (n = 44; 44%), broad‐based masses (n = 16; 26%), and bladder wall thickening (n = 25; 25%); mostly in the cranioventral bladder apex (n = 56; 80%). Of 41 specimens tested, none had evidence of the BRAF V595E mutation. Urinary tract neoplasia was not reported in any dog during follow‐up (range 1 month–8.4 years; median 8 months). Interventions included antibiotic or anti‐inflammatory administration, and surgical or cystoscopic ablation. During follow‐up, recurrent signs of lower urinary tract disease were reported in 23 (20%) dogs. Conclusions and Clinical Importance History of either UTI or urolithiasis, compatible imaging findings, and absence of detectable BRAF V595E mutation support the presumptive diagnosis of PoC in dogs. Affected dogs have a good prognosis, warranting differentiation from other urinary tract diseases.https://doi.org/10.1111/jvim.70049bladderBRAF V595E mutationinflammatorypolypurinary tract |
| spellingShingle | Matthew P. Price Rachael Thomas Mathew Breen Allison R. Kendall Shelly L. Vaden Polypoid Cystitis: A Retrospective Case‐Series of 112 Dogs Journal of Veterinary Internal Medicine bladder BRAF V595E mutation inflammatory polyp urinary tract |
| title | Polypoid Cystitis: A Retrospective Case‐Series of 112 Dogs |
| title_full | Polypoid Cystitis: A Retrospective Case‐Series of 112 Dogs |
| title_fullStr | Polypoid Cystitis: A Retrospective Case‐Series of 112 Dogs |
| title_full_unstemmed | Polypoid Cystitis: A Retrospective Case‐Series of 112 Dogs |
| title_short | Polypoid Cystitis: A Retrospective Case‐Series of 112 Dogs |
| title_sort | polypoid cystitis a retrospective case series of 112 dogs |
| topic | bladder BRAF V595E mutation inflammatory polyp urinary tract |
| url | https://doi.org/10.1111/jvim.70049 |
| work_keys_str_mv | AT matthewpprice polypoidcystitisaretrospectivecaseseriesof112dogs AT rachaelthomas polypoidcystitisaretrospectivecaseseriesof112dogs AT mathewbreen polypoidcystitisaretrospectivecaseseriesof112dogs AT allisonrkendall polypoidcystitisaretrospectivecaseseriesof112dogs AT shellylvaden polypoidcystitisaretrospectivecaseseriesof112dogs |