Mannose/stearyl chloride doubly functionalized polyethylenimine as a nucleic acid vaccine carrier to promote macrophage uptake

Mannose/stearyl chloride doubly functionalized polyethylenimine as a nucleic acid vaccine carrier to promote macrophage uptake

Transmembrane transport remains a significant challenge for nucleic acid vaccine vectors. Promoting the ability of immune cells, such as macrophages, to capture foreign stimuli is also an effective approach to improving cross-presentation. In addition, polyethyleneimine (PEI) has gained attention in...

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Bibliographic Details
Main Authors: Lu Bai, Xiaoqi Chen, Chengyu Li, Haijun Zhou, Yantao Li, Jijun Xiao, Fen Zhang, Hua Cheng, Mengmeng Zhou
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Drug Delivery
Subjects:
Polyethyleneimine
nucleic acid vaccine carrier
nanoparticle
endocytosis
vaccine delivery
Online Access:https://www.tandfonline.com/doi/10.1080/10717544.2024.2427138
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