Cancer therapeutic implications of microRNAs in the regulation of immune checkpoint blockade
Abstract Dampening of patients’ immune response to tumor-specific antigens is a major reason for tumor development and progression. Within tumor microenvironment, aberrant expression of immune checkpoints changes T lymphocyte activity, and induces immune tolerance or escape. Inhibiting these checkpo...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
ELS Publishing (ELSP)
2019-08-01
|
| Series: | ExRNA |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s41544-019-0022-0 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849411960107433984 |
|---|---|
| author | Yan Zhang Toshihiko Tanno Chrysi Kanellopoulou |
| author_facet | Yan Zhang Toshihiko Tanno Chrysi Kanellopoulou |
| author_sort | Yan Zhang |
| collection | DOAJ |
| description | Abstract Dampening of patients’ immune response to tumor-specific antigens is a major reason for tumor development and progression. Within tumor microenvironment, aberrant expression of immune checkpoints changes T lymphocyte activity, and induces immune tolerance or escape. Inhibiting these checkpoints, called immune-checkpoint blockade, causes the re-activation of the immune response to suppress tumor progression. microRNAs (miRNAs) are small non-coding RNAs that regulate multiple biological processes including carcinogenesis. miRNAs directly and indirectly control the expression of checkpoint receptors and can benefit the immune checkpoint blockade. In this review, we summarize what is known about miRNAs that regulate the expression of various immune checkpoints in cancer therapy and discuss the clinical implications that miRNAs could be useful therapeutic partners assisting the immune checkpoint therapy. |
| format | Article |
| id | doaj-art-4f62c187f9ab4f76abcee931f319db24 |
| institution | Kabale University |
| issn | 2398-0060 |
| language | English |
| publishDate | 2019-08-01 |
| publisher | ELS Publishing (ELSP) |
| record_format | Article |
| series | ExRNA |
| spelling | doaj-art-4f62c187f9ab4f76abcee931f319db242025-08-20T03:34:36ZengELS Publishing (ELSP)ExRNA2398-00602019-08-01111610.1186/s41544-019-0022-0Cancer therapeutic implications of microRNAs in the regulation of immune checkpoint blockadeYan Zhang0Toshihiko Tanno1Chrysi Kanellopoulou2Division of Immunotherapy, Institute of Human Virology (IHV), School of Medicine, University of MarylandDivision of Immunotherapy, Institute of Human Virology (IHV), School of Medicine, University of MarylandLaboratory of Immunology, NIAID, National Institutes of HealthAbstract Dampening of patients’ immune response to tumor-specific antigens is a major reason for tumor development and progression. Within tumor microenvironment, aberrant expression of immune checkpoints changes T lymphocyte activity, and induces immune tolerance or escape. Inhibiting these checkpoints, called immune-checkpoint blockade, causes the re-activation of the immune response to suppress tumor progression. microRNAs (miRNAs) are small non-coding RNAs that regulate multiple biological processes including carcinogenesis. miRNAs directly and indirectly control the expression of checkpoint receptors and can benefit the immune checkpoint blockade. In this review, we summarize what is known about miRNAs that regulate the expression of various immune checkpoints in cancer therapy and discuss the clinical implications that miRNAs could be useful therapeutic partners assisting the immune checkpoint therapy.http://link.springer.com/article/10.1186/s41544-019-0022-0Immune checkpoint blockadeCTLA-4PD-1PD-L1microRNA |
| spellingShingle | Yan Zhang Toshihiko Tanno Chrysi Kanellopoulou Cancer therapeutic implications of microRNAs in the regulation of immune checkpoint blockade ExRNA Immune checkpoint blockade CTLA-4 PD-1 PD-L1 microRNA |
| title | Cancer therapeutic implications of microRNAs in the regulation of immune checkpoint blockade |
| title_full | Cancer therapeutic implications of microRNAs in the regulation of immune checkpoint blockade |
| title_fullStr | Cancer therapeutic implications of microRNAs in the regulation of immune checkpoint blockade |
| title_full_unstemmed | Cancer therapeutic implications of microRNAs in the regulation of immune checkpoint blockade |
| title_short | Cancer therapeutic implications of microRNAs in the regulation of immune checkpoint blockade |
| title_sort | cancer therapeutic implications of micrornas in the regulation of immune checkpoint blockade |
| topic | Immune checkpoint blockade CTLA-4 PD-1 PD-L1 microRNA |
| url | http://link.springer.com/article/10.1186/s41544-019-0022-0 |
| work_keys_str_mv | AT yanzhang cancertherapeuticimplicationsofmicrornasintheregulationofimmunecheckpointblockade AT toshihikotanno cancertherapeuticimplicationsofmicrornasintheregulationofimmunecheckpointblockade AT chrysikanellopoulou cancertherapeuticimplicationsofmicrornasintheregulationofimmunecheckpointblockade |