Intravital imaging of a massive lymphocyte response in the cortical dura of mice after peripheral infection by trypanosomes.

Peripheral infection by Trypanosoma brucei, the protozoan responsible for sleeping sickness, activates lymphocytes, and, at later stages, causes meningoencephalitis. We have videoed the cortical meninges and superficial parenchyma of C56BL/6 reporter mice infected with T.b.brucei. By use of a two-ph...

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Bibliographic Details
Main Authors: Jonathan A Coles, Elmarie Myburgh, Ryan Ritchie, Alana Hamilton, Jean Rodgers, Jeremy C Mottram, Michael P Barrett, James M Brewer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-04-01
Series:PLoS Neglected Tropical Diseases
Online Access:https://doi.org/10.1371/journal.pntd.0003714
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