A prospective, split-face, randomized controlled trial of intense pulsed light-photodynamic therapy for seborrhea
Background: Seborrhea poses a common cosmetic concern in adolescents and young adults, often accompanied by enlarged pores, and contributing to various skin conditions, including acne vulgaris and seborrheic dermatitis. At present, there is a lack of effective treatment for this problem, and the pot...
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Elsevier
2024-02-01
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| Series: | Photodiagnosis and Photodynamic Therapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1572100024000127 |
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| author | Dixin Wang Yu Yan Peiru Wang Haiyan Zhang Yajing Cao Bo Wang Linglin Zhang Xiuli Wang |
| author_facet | Dixin Wang Yu Yan Peiru Wang Haiyan Zhang Yajing Cao Bo Wang Linglin Zhang Xiuli Wang |
| author_sort | Dixin Wang |
| collection | DOAJ |
| description | Background: Seborrhea poses a common cosmetic concern in adolescents and young adults, often accompanied by enlarged pores, and contributing to various skin conditions, including acne vulgaris and seborrheic dermatitis. At present, there is a lack of effective treatment for this problem, and the potential of photodynamic therapy (PDT) in reducing sebum remains inconclusive. Objective: This exploratory, prospective, single-center, double-blinded, randomized split-face controlled trial aimed to compare the efficacy and safety of intense pulsed light-photodynamic therapy (IPL-PDT) versus IPL therapy for seborrhea. Methods: Participants with seborrhea underwent 3 times of IPL treatment (590 nm, 15–17 J/cm2 based on patient's tolerance) for one hemifacial part and IPL-PDT treatment for the other. Follow-up assessment was conducted up to 8 weeks after the final treatment. Results: Compared with single IPL treatment, IPL-PDT can significantly inhibit sebum secretion and decrease pore size. PDT group exhibited no additional damage to the skin barrier, with even lower transepidermal water loss (TEWL). Additionally, the PDT group showed superior improvement in scores of porphyrins, red areas, and ultraviolet (UV) spots. Both groups experienced only mild topical adverse effects, well tolerated by the participants. Conclusion: IPL-PDT is a more effective method than IPL in the treatment of seborrhea, as well as on the improvement of the skin barrier function. |
| format | Article |
| id | doaj-art-4f5a853ee66a4e4aa4b05b7233a2fe8a |
| institution | Kabale University |
| issn | 1572-1000 |
| language | English |
| publishDate | 2024-02-01 |
| publisher | Elsevier |
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| series | Photodiagnosis and Photodynamic Therapy |
| spelling | doaj-art-4f5a853ee66a4e4aa4b05b7233a2fe8a2024-12-11T05:55:36ZengElsevierPhotodiagnosis and Photodynamic Therapy1572-10002024-02-0145103973A prospective, split-face, randomized controlled trial of intense pulsed light-photodynamic therapy for seborrheaDixin Wang0Yu Yan1Peiru Wang2Haiyan Zhang3Yajing Cao4Bo Wang5Linglin Zhang6Xiuli Wang7Institute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, ChinaInstitute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, ChinaInstitute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, ChinaInstitute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, ChinaInstitute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Dermatology, University of Michigan, Ann Arbor, Michigan 48109, United States; Avera Medical Group Dermatology Aberdeen, Aberdeen, South Dakota 57401, United StatesInstitute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, China; Corresponding authors at: Institute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai 200043, China.Institute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, China; Corresponding authors at: Institute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai 200043, China.Background: Seborrhea poses a common cosmetic concern in adolescents and young adults, often accompanied by enlarged pores, and contributing to various skin conditions, including acne vulgaris and seborrheic dermatitis. At present, there is a lack of effective treatment for this problem, and the potential of photodynamic therapy (PDT) in reducing sebum remains inconclusive. Objective: This exploratory, prospective, single-center, double-blinded, randomized split-face controlled trial aimed to compare the efficacy and safety of intense pulsed light-photodynamic therapy (IPL-PDT) versus IPL therapy for seborrhea. Methods: Participants with seborrhea underwent 3 times of IPL treatment (590 nm, 15–17 J/cm2 based on patient's tolerance) for one hemifacial part and IPL-PDT treatment for the other. Follow-up assessment was conducted up to 8 weeks after the final treatment. Results: Compared with single IPL treatment, IPL-PDT can significantly inhibit sebum secretion and decrease pore size. PDT group exhibited no additional damage to the skin barrier, with even lower transepidermal water loss (TEWL). Additionally, the PDT group showed superior improvement in scores of porphyrins, red areas, and ultraviolet (UV) spots. Both groups experienced only mild topical adverse effects, well tolerated by the participants. Conclusion: IPL-PDT is a more effective method than IPL in the treatment of seborrhea, as well as on the improvement of the skin barrier function.http://www.sciencedirect.com/science/article/pii/S1572100024000127Oily skinSeborrheic skinIntense pulsed light-photodynamic therapy (IPL-PDT)5-Aminolevulinic acid photodynamic therapy (ALA-PDT)Photodynamic therapy (PDT) |
| spellingShingle | Dixin Wang Yu Yan Peiru Wang Haiyan Zhang Yajing Cao Bo Wang Linglin Zhang Xiuli Wang A prospective, split-face, randomized controlled trial of intense pulsed light-photodynamic therapy for seborrhea Photodiagnosis and Photodynamic Therapy Oily skin Seborrheic skin Intense pulsed light-photodynamic therapy (IPL-PDT) 5-Aminolevulinic acid photodynamic therapy (ALA-PDT) Photodynamic therapy (PDT) |
| title | A prospective, split-face, randomized controlled trial of intense pulsed light-photodynamic therapy for seborrhea |
| title_full | A prospective, split-face, randomized controlled trial of intense pulsed light-photodynamic therapy for seborrhea |
| title_fullStr | A prospective, split-face, randomized controlled trial of intense pulsed light-photodynamic therapy for seborrhea |
| title_full_unstemmed | A prospective, split-face, randomized controlled trial of intense pulsed light-photodynamic therapy for seborrhea |
| title_short | A prospective, split-face, randomized controlled trial of intense pulsed light-photodynamic therapy for seborrhea |
| title_sort | prospective split face randomized controlled trial of intense pulsed light photodynamic therapy for seborrhea |
| topic | Oily skin Seborrheic skin Intense pulsed light-photodynamic therapy (IPL-PDT) 5-Aminolevulinic acid photodynamic therapy (ALA-PDT) Photodynamic therapy (PDT) |
| url | http://www.sciencedirect.com/science/article/pii/S1572100024000127 |
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