Case Report: Management of recurrent UTI with tigecycline in a kidney transplant recipient
This case report describes a 37-year-old man who underwent renal transplantation and subsequently developed complicated recurrent urinary tract infections (UTIs) caused by multidrug-resistant (MDR) Klebsiella pneumoniae. Despite initial treatment with fosfomycin and meropenem, the patient experience...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Transplantation |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/frtra.2024.1496702/full |
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| author | Supreeta R. Shettar Mahadevaiah Neelambike Sumana Manjunath S. Shetty Yogeesh D. Maheshwarappa Raghukanth G. Reddy Asha Srinivasan Vamshi Dharan P Gautam Kalyatanda Shruthi Shree S C |
| author_facet | Supreeta R. Shettar Mahadevaiah Neelambike Sumana Manjunath S. Shetty Yogeesh D. Maheshwarappa Raghukanth G. Reddy Asha Srinivasan Vamshi Dharan P Gautam Kalyatanda Shruthi Shree S C |
| author_sort | Supreeta R. Shettar |
| collection | DOAJ |
| description | This case report describes a 37-year-old man who underwent renal transplantation and subsequently developed complicated recurrent urinary tract infections (UTIs) caused by multidrug-resistant (MDR) Klebsiella pneumoniae. Despite initial treatment with fosfomycin and meropenem, the patient experienced persistent UTIs, leading to multiple hospitalizations. The management of these recurrent infections eventually required the use of tigecycline. Although tigecycline is not typically considered a urinary antibiotic owing to its limited urinary excretion, it was successfully employed in this case to manage the recurrent infections. The patient was treated with tigecycline for several episodes of UTI, which provided a crucial therapeutic option in the context of antibiotic resistance. This case underscores the challenges of managing recurrent MDR UTIs in immunocompromised patients and highlights tigecycline as an effective treatment strategy when standard therapies fail. |
| format | Article |
| id | doaj-art-4f57a2be2f7440e98c80a85dc7bd7f8b |
| institution | DOAJ |
| issn | 2813-2440 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Transplantation |
| spelling | doaj-art-4f57a2be2f7440e98c80a85dc7bd7f8b2025-08-20T02:43:16ZengFrontiers Media S.A.Frontiers in Transplantation2813-24402025-02-01310.3389/frtra.2024.14967021496702Case Report: Management of recurrent UTI with tigecycline in a kidney transplant recipientSupreeta R. Shettar0Mahadevaiah Neelambike Sumana1Manjunath S. Shetty2Yogeesh D. Maheshwarappa3Raghukanth G. Reddy4Asha Srinivasan5Vamshi Dharan P6Gautam Kalyatanda7Shruthi Shree S C8JSS Medical College and Hospital, JSS Academy of Higher Education and Research, Mysuru, IndiaJSS Medical College and Hospital, JSS Academy of Higher Education and Research, Mysuru, IndiaJSS Medical College and Hospital, JSS Academy of Higher Education and Research, Mysuru, IndiaJSS Medical College and Hospital, JSS Academy of Higher Education and Research, Mysuru, IndiaJSS Medical College and Hospital, JSS Academy of Higher Education and Research, Mysuru, IndiaDivision of Nanoscience and Technology, School of Life Sciences, JSS Academy of Higher Education and Research, Mysuru, IndiaJSS Medical College and Hospital, JSS Academy of Higher Education and Research, Mysuru, IndiaDivision of Infectious Disease and Global Medicine, University of Florida, Gainesville, FL, United StatesJSS Medical College and Hospital, JSS Academy of Higher Education and Research, Mysuru, IndiaThis case report describes a 37-year-old man who underwent renal transplantation and subsequently developed complicated recurrent urinary tract infections (UTIs) caused by multidrug-resistant (MDR) Klebsiella pneumoniae. Despite initial treatment with fosfomycin and meropenem, the patient experienced persistent UTIs, leading to multiple hospitalizations. The management of these recurrent infections eventually required the use of tigecycline. Although tigecycline is not typically considered a urinary antibiotic owing to its limited urinary excretion, it was successfully employed in this case to manage the recurrent infections. The patient was treated with tigecycline for several episodes of UTI, which provided a crucial therapeutic option in the context of antibiotic resistance. This case underscores the challenges of managing recurrent MDR UTIs in immunocompromised patients and highlights tigecycline as an effective treatment strategy when standard therapies fail.https://www.frontiersin.org/articles/10.3389/frtra.2024.1496702/fullmulti-drug resistant Klebsiella pneumoniaemultidrug-resistant organismsurinary tract infectionkidney transplantationimmunocompromised conditions |
| spellingShingle | Supreeta R. Shettar Mahadevaiah Neelambike Sumana Manjunath S. Shetty Yogeesh D. Maheshwarappa Raghukanth G. Reddy Asha Srinivasan Vamshi Dharan P Gautam Kalyatanda Shruthi Shree S C Case Report: Management of recurrent UTI with tigecycline in a kidney transplant recipient Frontiers in Transplantation multi-drug resistant Klebsiella pneumoniae multidrug-resistant organisms urinary tract infection kidney transplantation immunocompromised conditions |
| title | Case Report: Management of recurrent UTI with tigecycline in a kidney transplant recipient |
| title_full | Case Report: Management of recurrent UTI with tigecycline in a kidney transplant recipient |
| title_fullStr | Case Report: Management of recurrent UTI with tigecycline in a kidney transplant recipient |
| title_full_unstemmed | Case Report: Management of recurrent UTI with tigecycline in a kidney transplant recipient |
| title_short | Case Report: Management of recurrent UTI with tigecycline in a kidney transplant recipient |
| title_sort | case report management of recurrent uti with tigecycline in a kidney transplant recipient |
| topic | multi-drug resistant Klebsiella pneumoniae multidrug-resistant organisms urinary tract infection kidney transplantation immunocompromised conditions |
| url | https://www.frontiersin.org/articles/10.3389/frtra.2024.1496702/full |
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