Immunotherapy for Recurrent and Metastatic Cervical Cancer: A Review
Objectives: This review aims to summarize the current literature on recurrent and metastatic (r/m) cervical cancer, especially first-line and second-line immunotherapy. Clinical benefits including efficacy and safety of new therapeutic options are also reviewed. Mechanism: The published relevant art...
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| Format: | Article |
| Language: | English |
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IMR Press
2024-07-01
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| Series: | Clinical and Experimental Obstetrics & Gynecology |
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| Online Access: | https://www.imrpress.com/journal/CEOG/51/7/10.31083/j.ceog5107155 |
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| _version_ | 1849693862771032064 |
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| author | Yuke Wu Xiang He |
| author_facet | Yuke Wu Xiang He |
| author_sort | Yuke Wu |
| collection | DOAJ |
| description | Objectives: This review aims to summarize the current literature on recurrent and metastatic (r/m) cervical cancer, especially first-line and second-line immunotherapy. Clinical benefits including efficacy and safety of new therapeutic options are also reviewed. Mechanism: The published relevant articles were searched from multiple databases, including PubMed, Ovid, and Scopus. The key terms included recurrent cervical cancer, advanced cervical cancer, metastatic cervical cancer, and immunotherapy. The data of the latest clinical trials was retrieved from ClinicalTrials.gov (https://clinicaltrials.gov). Findings in Brief: In late 2021, pembrolizumab in combination with chemotherapy with or without bevacizumab was approved as the first-line treatment for recurrent and metastatic cervical cancer. Also tisotumab vedotin was approved as the second-line immunotherapy for r/m cervical cancer. Moreover, a plethora of clinical immunotherapy trials were approved in different countries, and some received as breakthrough therapy designations. Pembrolizumab, cemiplimab, atezolizumab, cadonilimab, zimberelimab, balstilimab and zalifrelimab, nivolumab, and tisotumab vedotin were reviewed with overall survival, progression-free survival, rate of objective response and adverse effects in order to review the efficacy and safety of different therapeutic option. Conclusions: The majority of trials indicated that immunotherapy can significantly improve the overall survival (OS) and progression-free survival (PFS) of r/m cervical cancer patients without negatively affecting health-related quality-of-life (HRQoL), and demonstrated that immunotherapy is an effective and safe treatment for r/m cervical cancer. |
| format | Article |
| id | doaj-art-4f57a1c7c13c48c1bc71f7cdf102b448 |
| institution | DOAJ |
| issn | 0390-6663 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Clinical and Experimental Obstetrics & Gynecology |
| spelling | doaj-art-4f57a1c7c13c48c1bc71f7cdf102b4482025-08-20T03:20:16ZengIMR PressClinical and Experimental Obstetrics & Gynecology0390-66632024-07-0151715510.31083/j.ceog5107155S0390-6663(24)02364-9Immunotherapy for Recurrent and Metastatic Cervical Cancer: A ReviewYuke Wu0Xiang He1Department of Gynecology and Obstetrics, West China Second University Hospital, Sichuan University, 610041 Chengdu, Sichuan, ChinaDepartment of Gynecology and Obstetrics, West China Second University Hospital, Sichuan University, 610041 Chengdu, Sichuan, ChinaObjectives: This review aims to summarize the current literature on recurrent and metastatic (r/m) cervical cancer, especially first-line and second-line immunotherapy. Clinical benefits including efficacy and safety of new therapeutic options are also reviewed. Mechanism: The published relevant articles were searched from multiple databases, including PubMed, Ovid, and Scopus. The key terms included recurrent cervical cancer, advanced cervical cancer, metastatic cervical cancer, and immunotherapy. The data of the latest clinical trials was retrieved from ClinicalTrials.gov (https://clinicaltrials.gov). Findings in Brief: In late 2021, pembrolizumab in combination with chemotherapy with or without bevacizumab was approved as the first-line treatment for recurrent and metastatic cervical cancer. Also tisotumab vedotin was approved as the second-line immunotherapy for r/m cervical cancer. Moreover, a plethora of clinical immunotherapy trials were approved in different countries, and some received as breakthrough therapy designations. Pembrolizumab, cemiplimab, atezolizumab, cadonilimab, zimberelimab, balstilimab and zalifrelimab, nivolumab, and tisotumab vedotin were reviewed with overall survival, progression-free survival, rate of objective response and adverse effects in order to review the efficacy and safety of different therapeutic option. Conclusions: The majority of trials indicated that immunotherapy can significantly improve the overall survival (OS) and progression-free survival (PFS) of r/m cervical cancer patients without negatively affecting health-related quality-of-life (HRQoL), and demonstrated that immunotherapy is an effective and safe treatment for r/m cervical cancer.https://www.imrpress.com/journal/CEOG/51/7/10.31083/j.ceog5107155recurrent and metastatic cervical canceradvanced cervical cancerfirst-line immunotherapysecond-line immunotherapy |
| spellingShingle | Yuke Wu Xiang He Immunotherapy for Recurrent and Metastatic Cervical Cancer: A Review Clinical and Experimental Obstetrics & Gynecology recurrent and metastatic cervical cancer advanced cervical cancer first-line immunotherapy second-line immunotherapy |
| title | Immunotherapy for Recurrent and Metastatic Cervical Cancer: A Review |
| title_full | Immunotherapy for Recurrent and Metastatic Cervical Cancer: A Review |
| title_fullStr | Immunotherapy for Recurrent and Metastatic Cervical Cancer: A Review |
| title_full_unstemmed | Immunotherapy for Recurrent and Metastatic Cervical Cancer: A Review |
| title_short | Immunotherapy for Recurrent and Metastatic Cervical Cancer: A Review |
| title_sort | immunotherapy for recurrent and metastatic cervical cancer a review |
| topic | recurrent and metastatic cervical cancer advanced cervical cancer first-line immunotherapy second-line immunotherapy |
| url | https://www.imrpress.com/journal/CEOG/51/7/10.31083/j.ceog5107155 |
| work_keys_str_mv | AT yukewu immunotherapyforrecurrentandmetastaticcervicalcancerareview AT xianghe immunotherapyforrecurrentandmetastaticcervicalcancerareview |