Distinct inflammation-related proteins associated with T cell immune recovery during chronic HIV-1 infection
Chronic inflammation and T cell dysregulation persist in individuals infected with human immunodeficiency virus type 1 (HIV-1), even after successful antiretroviral treatment. The mechanism involved is not fully understood. Here, we used Olink proteomics to comprehensively analyze the aberrant infla...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Emerging Microbes and Infections |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/22221751.2022.2150566 |
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| author | Lin-Yu Wan Hui-Huang Huang Cheng Zhen Si-Yuan Chen Bing Song Wen-Jing Cao Li-Li Shen Ming-Ju Zhou Xiao-Chang Zhang Ruonan Xu Xing Fan Ji-Yuan Zhang Ming Shi Chao Zhang Yan-Mei Jiao Jin-Wen Song Fu-Sheng Wang |
| author_facet | Lin-Yu Wan Hui-Huang Huang Cheng Zhen Si-Yuan Chen Bing Song Wen-Jing Cao Li-Li Shen Ming-Ju Zhou Xiao-Chang Zhang Ruonan Xu Xing Fan Ji-Yuan Zhang Ming Shi Chao Zhang Yan-Mei Jiao Jin-Wen Song Fu-Sheng Wang |
| author_sort | Lin-Yu Wan |
| collection | DOAJ |
| description | Chronic inflammation and T cell dysregulation persist in individuals infected with human immunodeficiency virus type 1 (HIV-1), even after successful antiretroviral treatment. The mechanism involved is not fully understood. Here, we used Olink proteomics to comprehensively analyze the aberrant inflammation-related proteins (IRPs) in chronic HIV-1-infected individuals, including in 24 treatment-naïve individuals, 33 immunological responders, and 38 immunological non-responders. T cell dysfunction was evaluated as T cell exhaustion, activation, and differentiation using flow cytometry. We identified a cluster of IRPs (cluster 7), including CXCL11, CXCL9, TNF, CXCL10, and IL18, which was closely associated with T cell dysregulation during chronic HIV-1 infection. Interestingly, IRPs in cluster 5, including ST1A1, CASP8, SIRT2, AXIN1, STAMBP, CD40, and IL7, were negatively correlated with the HIV-1 reservoir size. We also identified a combination of CDCP1, CXCL11, CST5, SLAMF1, TRANCE, and CD5, which may be useful for distinguishing immunological responders and immunological non-responders. In conclusion, the distinct inflammatory milieu is closely associated with immune restoration of T cells, and our results provide insight into immune dysregulation during chronic HIV-1 infection. |
| format | Article |
| id | doaj-art-4f52b506b44e49eeadf5c41cc28f051e |
| institution | DOAJ |
| issn | 2222-1751 |
| language | English |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Emerging Microbes and Infections |
| spelling | doaj-art-4f52b506b44e49eeadf5c41cc28f051e2025-08-20T02:59:13ZengTaylor & Francis GroupEmerging Microbes and Infections2222-17512023-12-0112110.1080/22221751.2022.2150566Distinct inflammation-related proteins associated with T cell immune recovery during chronic HIV-1 infectionLin-Yu Wan0Hui-Huang Huang1Cheng Zhen2Si-Yuan Chen3Bing Song4Wen-Jing Cao5Li-Li Shen6Ming-Ju Zhou7Xiao-Chang Zhang8Ruonan Xu9Xing Fan10Ji-Yuan Zhang11Ming Shi12Chao Zhang13Yan-Mei Jiao14Jin-Wen Song15Fu-Sheng Wang16The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, ChinaDepartment of Infectious Diseases, the Fifth Medical Center of Chinese PLA General Hospital, National Clinical Research Center for Infectious Diseases, Beijing, ChinaDepartment of Infectious Diseases, the Fifth Medical Center of Chinese PLA General Hospital, National Clinical Research Center for Infectious Diseases, Beijing, ChinaDepartment of Infectious Diseases, the Fifth Medical Center of Chinese PLA General Hospital, National Clinical Research Center for Infectious Diseases, Beijing, ChinaDepartment of Infectious Diseases, the Fifth Medical Center of Chinese PLA General Hospital, National Clinical Research Center for Infectious Diseases, Beijing, ChinaThe First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, ChinaDepartment of Clinical Medicine, Bengbu Medical College, Bengbu, ChinaDepartment of Infectious Diseases, the Fifth Medical Center of Chinese PLA General Hospital, National Clinical Research Center for Infectious Diseases, Beijing, ChinaBeijing Institute of Radiation Medicine, Beijing, ChinaDepartment of Infectious Diseases, the Fifth Medical Center of Chinese PLA General Hospital, National Clinical Research Center for Infectious Diseases, Beijing, ChinaDepartment of Infectious Diseases, the Fifth Medical Center of Chinese PLA General Hospital, National Clinical Research Center for Infectious Diseases, Beijing, ChinaDepartment of Infectious Diseases, the Fifth Medical Center of Chinese PLA General Hospital, National Clinical Research Center for Infectious Diseases, Beijing, ChinaDepartment of Infectious Diseases, the Fifth Medical Center of Chinese PLA General Hospital, National Clinical Research Center for Infectious Diseases, Beijing, ChinaDepartment of Infectious Diseases, the Fifth Medical Center of Chinese PLA General Hospital, National Clinical Research Center for Infectious Diseases, Beijing, ChinaDepartment of Infectious Diseases, the Fifth Medical Center of Chinese PLA General Hospital, National Clinical Research Center for Infectious Diseases, Beijing, ChinaDepartment of Infectious Diseases, the Fifth Medical Center of Chinese PLA General Hospital, National Clinical Research Center for Infectious Diseases, Beijing, ChinaThe First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, ChinaChronic inflammation and T cell dysregulation persist in individuals infected with human immunodeficiency virus type 1 (HIV-1), even after successful antiretroviral treatment. The mechanism involved is not fully understood. Here, we used Olink proteomics to comprehensively analyze the aberrant inflammation-related proteins (IRPs) in chronic HIV-1-infected individuals, including in 24 treatment-naïve individuals, 33 immunological responders, and 38 immunological non-responders. T cell dysfunction was evaluated as T cell exhaustion, activation, and differentiation using flow cytometry. We identified a cluster of IRPs (cluster 7), including CXCL11, CXCL9, TNF, CXCL10, and IL18, which was closely associated with T cell dysregulation during chronic HIV-1 infection. Interestingly, IRPs in cluster 5, including ST1A1, CASP8, SIRT2, AXIN1, STAMBP, CD40, and IL7, were negatively correlated with the HIV-1 reservoir size. We also identified a combination of CDCP1, CXCL11, CST5, SLAMF1, TRANCE, and CD5, which may be useful for distinguishing immunological responders and immunological non-responders. In conclusion, the distinct inflammatory milieu is closely associated with immune restoration of T cells, and our results provide insight into immune dysregulation during chronic HIV-1 infection.https://www.tandfonline.com/doi/10.1080/22221751.2022.2150566HIV-1InflammationHIV-1 reservoirCXCL9CXCL10CXCL11 |
| spellingShingle | Lin-Yu Wan Hui-Huang Huang Cheng Zhen Si-Yuan Chen Bing Song Wen-Jing Cao Li-Li Shen Ming-Ju Zhou Xiao-Chang Zhang Ruonan Xu Xing Fan Ji-Yuan Zhang Ming Shi Chao Zhang Yan-Mei Jiao Jin-Wen Song Fu-Sheng Wang Distinct inflammation-related proteins associated with T cell immune recovery during chronic HIV-1 infection Emerging Microbes and Infections HIV-1 Inflammation HIV-1 reservoir CXCL9 CXCL10 CXCL11 |
| title | Distinct inflammation-related proteins associated with T cell immune recovery during chronic HIV-1 infection |
| title_full | Distinct inflammation-related proteins associated with T cell immune recovery during chronic HIV-1 infection |
| title_fullStr | Distinct inflammation-related proteins associated with T cell immune recovery during chronic HIV-1 infection |
| title_full_unstemmed | Distinct inflammation-related proteins associated with T cell immune recovery during chronic HIV-1 infection |
| title_short | Distinct inflammation-related proteins associated with T cell immune recovery during chronic HIV-1 infection |
| title_sort | distinct inflammation related proteins associated with t cell immune recovery during chronic hiv 1 infection |
| topic | HIV-1 Inflammation HIV-1 reservoir CXCL9 CXCL10 CXCL11 |
| url | https://www.tandfonline.com/doi/10.1080/22221751.2022.2150566 |
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