Pancreatic Acinar Cell Carcinoma in the Setting of a BRCA1 Germline Mutation
Pancreatic acinar cell carcinoma (PACC) is a rare neoplasm of the exocrine pancreas. PACC’s molecular and genetic features are poorly elucidated compared with pancreatic ductal cell carcinoma. Here, we present the patient case of a woman in her late 60s, with a BRCA1 germline mutation and a medical...
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| Format: | Article |
| Language: | English |
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American College of Physicians
2022-09-01
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| Series: | Annals of Internal Medicine: Clinical Cases |
| Online Access: | https://www.acpjournals.org/doi/10.7326/aimcc.2022.0596 |
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| author | Leticia Campoverde Monika Vyas Andrea Bullock |
| author_facet | Leticia Campoverde Monika Vyas Andrea Bullock |
| author_sort | Leticia Campoverde |
| collection | DOAJ |
| description | Pancreatic acinar cell carcinoma (PACC) is a rare neoplasm of the exocrine pancreas. PACC’s molecular and genetic features are poorly elucidated compared with pancreatic ductal cell carcinoma. Here, we present the patient case of a woman in her late 60s, with a BRCA1 germline mutation and a medical history of breast and lung adenocarcinomas diagnosed with PACC. A literature search identified only 2 reported cases of PACC associated with a BRCA1 germline mutation. |
| format | Article |
| id | doaj-art-4f523e3ff32e4bd799ec592f7aba0c36 |
| institution | OA Journals |
| issn | 2767-7664 |
| language | English |
| publishDate | 2022-09-01 |
| publisher | American College of Physicians |
| record_format | Article |
| series | Annals of Internal Medicine: Clinical Cases |
| spelling | doaj-art-4f523e3ff32e4bd799ec592f7aba0c362025-08-20T02:11:46ZengAmerican College of PhysiciansAnnals of Internal Medicine: Clinical Cases2767-76642022-09-011710.7326/aimcc.2022.0596Pancreatic Acinar Cell Carcinoma in the Setting of a BRCA1 Germline MutationLeticia Campoverde0Monika Vyas1Andrea Bullock21Internal Medicine Residency Training Program, Division of Internal Medicine, Jackson Memorial Hospital-University of Miami, Miami, Florida2Medical Oncology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts3Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MassachusettsPancreatic acinar cell carcinoma (PACC) is a rare neoplasm of the exocrine pancreas. PACC’s molecular and genetic features are poorly elucidated compared with pancreatic ductal cell carcinoma. Here, we present the patient case of a woman in her late 60s, with a BRCA1 germline mutation and a medical history of breast and lung adenocarcinomas diagnosed with PACC. A literature search identified only 2 reported cases of PACC associated with a BRCA1 germline mutation.https://www.acpjournals.org/doi/10.7326/aimcc.2022.0596 |
| spellingShingle | Leticia Campoverde Monika Vyas Andrea Bullock Pancreatic Acinar Cell Carcinoma in the Setting of a BRCA1 Germline Mutation Annals of Internal Medicine: Clinical Cases |
| title | Pancreatic Acinar Cell Carcinoma in the Setting of a BRCA1 Germline Mutation |
| title_full | Pancreatic Acinar Cell Carcinoma in the Setting of a BRCA1 Germline Mutation |
| title_fullStr | Pancreatic Acinar Cell Carcinoma in the Setting of a BRCA1 Germline Mutation |
| title_full_unstemmed | Pancreatic Acinar Cell Carcinoma in the Setting of a BRCA1 Germline Mutation |
| title_short | Pancreatic Acinar Cell Carcinoma in the Setting of a BRCA1 Germline Mutation |
| title_sort | pancreatic acinar cell carcinoma in the setting of a brca1 germline mutation |
| url | https://www.acpjournals.org/doi/10.7326/aimcc.2022.0596 |
| work_keys_str_mv | AT leticiacampoverde pancreaticacinarcellcarcinomainthesettingofabrca1germlinemutation AT monikavyas pancreaticacinarcellcarcinomainthesettingofabrca1germlinemutation AT andreabullock pancreaticacinarcellcarcinomainthesettingofabrca1germlinemutation |