Tissue Factor in Dermatitis Herpetiformis and Bullous Pemphigoid: Link between Immune and Coagulation System in Subepidermal Autoimmune Bullous Diseases
Dermatitis herpetiformis (DH) and bullous pemphigoid (BP) are skin diseases associated with eosinophilic and neutrophilic infiltrations. Although chemokines are critical for the selective accumulation and activation of various leukocyte subsets in the inflammatory process, there are few findings con...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2015/870428 |
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| author | Agnieszka Zebrowska Malgorzata Wagrowska-Danilewicz Marian Danilewicz Joanna Wieczfinska Ewa Pniewska Michal Zebrowski Elzbieta Waszczykowska Anna Wozniacka Makandjou-Ola Eusebio Miroslawa Pietruczuk Rafal Pawliczak |
| author_facet | Agnieszka Zebrowska Malgorzata Wagrowska-Danilewicz Marian Danilewicz Joanna Wieczfinska Ewa Pniewska Michal Zebrowski Elzbieta Waszczykowska Anna Wozniacka Makandjou-Ola Eusebio Miroslawa Pietruczuk Rafal Pawliczak |
| author_sort | Agnieszka Zebrowska |
| collection | DOAJ |
| description | Dermatitis herpetiformis (DH) and bullous pemphigoid (BP) are skin diseases associated with eosinophilic and neutrophilic infiltrations. Although chemokines are critical for the selective accumulation and activation of various leukocyte subsets in the inflammatory process, there are few findings concerning inflammatory cells and production of coagulation factors in blistering diseases. Skin biopsies were taken from 14 patients with DH, 27 with BP, and 20 control subjects. The localization and expression of tissue factor (TF) in skin lesions and perilesional skin were studied by immunohistochemistry and confirmed by Western Blot. Moreover the plasma concentrations of TF were measured by immunoassays. D dimers, fibrinogen, and selected coagulation parameters were measured by routine methods. Expression of TF in the epidermis and in inflammatory influxed cells in dermis was detected in skin biopsies from BP patients. Examined TF expression was detected in perilesional skin of all BP patients too. The expression of TF was not observed in biopsies from healthy people and DH patients. The findings of the study show an increased expression of tissue factor in the lesional and perilesional skin of patients with bullous pemphigoid. The difference in chemokine pattern expression and variations in the cellular infiltration in BP and DH cause variable expression of TF. |
| format | Article |
| id | doaj-art-4f50c2d8686c4c63ad89a22fd77b001c |
| institution | DOAJ |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-4f50c2d8686c4c63ad89a22fd77b001c2025-08-20T03:20:16ZengWileyMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/870428870428Tissue Factor in Dermatitis Herpetiformis and Bullous Pemphigoid: Link between Immune and Coagulation System in Subepidermal Autoimmune Bullous DiseasesAgnieszka Zebrowska0Malgorzata Wagrowska-Danilewicz1Marian Danilewicz2Joanna Wieczfinska3Ewa Pniewska4Michal Zebrowski5Elzbieta Waszczykowska6Anna Wozniacka7Makandjou-Ola Eusebio8Miroslawa Pietruczuk9Rafal Pawliczak10Department of Dermatology and Venereology, Medical University of Lodz, Hallera Square 1, 90-497 Lodz, PolandLaboratory of Nephropathology, Medical University of Lodz, Pomorska 251 Street, 92-213 Lodz, PolandLaboratory of Nephropathology, Medical University of Lodz, Pomorska 251 Street, 92-213 Lodz, PolandDepartment of Immunopathology, Faculty of Biomedical Sciences and Postgraduate Training, Medical University of Lodz, Zeligowskiego 7/9, 90-752 Lodz, PolandDepartment of Immunopathology, Faculty of Biomedical Sciences and Postgraduate Training, Medical University of Lodz, Zeligowskiego 7/9, 90-752 Lodz, PolandDepartment of Social Medicine, Medical University of Lodz, Zeligowskiego 7/9, 90-752 Lodz, PolandDepartment of Dermatology and Venereology, Medical University of Lodz, Hallera Square 1, 90-497 Lodz, PolandDepartment of Dermatology and Venereology, Medical University of Lodz, Hallera Square 1, 90-497 Lodz, PolandDepartment of Laboratory Diagnostics, Medical University of Lodz, Kopcinskiego 22, 90-153 Lodz, PolandDepartment of Laboratory Diagnostics, Medical University of Lodz, Kopcinskiego 22, 90-153 Lodz, PolandDepartment of Immunopathology, Faculty of Biomedical Sciences and Postgraduate Training, Medical University of Lodz, Zeligowskiego 7/9, 90-752 Lodz, PolandDermatitis herpetiformis (DH) and bullous pemphigoid (BP) are skin diseases associated with eosinophilic and neutrophilic infiltrations. Although chemokines are critical for the selective accumulation and activation of various leukocyte subsets in the inflammatory process, there are few findings concerning inflammatory cells and production of coagulation factors in blistering diseases. Skin biopsies were taken from 14 patients with DH, 27 with BP, and 20 control subjects. The localization and expression of tissue factor (TF) in skin lesions and perilesional skin were studied by immunohistochemistry and confirmed by Western Blot. Moreover the plasma concentrations of TF were measured by immunoassays. D dimers, fibrinogen, and selected coagulation parameters were measured by routine methods. Expression of TF in the epidermis and in inflammatory influxed cells in dermis was detected in skin biopsies from BP patients. Examined TF expression was detected in perilesional skin of all BP patients too. The expression of TF was not observed in biopsies from healthy people and DH patients. The findings of the study show an increased expression of tissue factor in the lesional and perilesional skin of patients with bullous pemphigoid. The difference in chemokine pattern expression and variations in the cellular infiltration in BP and DH cause variable expression of TF.http://dx.doi.org/10.1155/2015/870428 |
| spellingShingle | Agnieszka Zebrowska Malgorzata Wagrowska-Danilewicz Marian Danilewicz Joanna Wieczfinska Ewa Pniewska Michal Zebrowski Elzbieta Waszczykowska Anna Wozniacka Makandjou-Ola Eusebio Miroslawa Pietruczuk Rafal Pawliczak Tissue Factor in Dermatitis Herpetiformis and Bullous Pemphigoid: Link between Immune and Coagulation System in Subepidermal Autoimmune Bullous Diseases Mediators of Inflammation |
| title | Tissue Factor in Dermatitis Herpetiformis and Bullous Pemphigoid: Link between Immune and Coagulation System in Subepidermal Autoimmune Bullous Diseases |
| title_full | Tissue Factor in Dermatitis Herpetiformis and Bullous Pemphigoid: Link between Immune and Coagulation System in Subepidermal Autoimmune Bullous Diseases |
| title_fullStr | Tissue Factor in Dermatitis Herpetiformis and Bullous Pemphigoid: Link between Immune and Coagulation System in Subepidermal Autoimmune Bullous Diseases |
| title_full_unstemmed | Tissue Factor in Dermatitis Herpetiformis and Bullous Pemphigoid: Link between Immune and Coagulation System in Subepidermal Autoimmune Bullous Diseases |
| title_short | Tissue Factor in Dermatitis Herpetiformis and Bullous Pemphigoid: Link between Immune and Coagulation System in Subepidermal Autoimmune Bullous Diseases |
| title_sort | tissue factor in dermatitis herpetiformis and bullous pemphigoid link between immune and coagulation system in subepidermal autoimmune bullous diseases |
| url | http://dx.doi.org/10.1155/2015/870428 |
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