Apathy and Reduced Speed of Processing Underlie Decline in Verbal Fluency following DBS
Objective. Reduced verbal fluency is a strikingly uniform finding following deep brain stimulation (DBS) for Parkinson’s disease (PD). The precise cognitive mechanism underlying this reduction remains unclear, but theories have suggested reduced motivation, linguistic skill, and/or executive functio...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2017-01-01
|
| Series: | Behavioural Neurology |
| Online Access: | http://dx.doi.org/10.1155/2017/7348101 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849693748656603136 |
|---|---|
| author | Jennifer A. Foley Tom Foltynie Ludvic Zrinzo Jonathan A. Hyam Patricia Limousin Lisa Cipolotti |
| author_facet | Jennifer A. Foley Tom Foltynie Ludvic Zrinzo Jonathan A. Hyam Patricia Limousin Lisa Cipolotti |
| author_sort | Jennifer A. Foley |
| collection | DOAJ |
| description | Objective. Reduced verbal fluency is a strikingly uniform finding following deep brain stimulation (DBS) for Parkinson’s disease (PD). The precise cognitive mechanism underlying this reduction remains unclear, but theories have suggested reduced motivation, linguistic skill, and/or executive function. It is of note, however, that previous reports have failed to consider the potential role of any changes in speed of processing. Thus, the aim of this study was to examine verbal fluency changes with a particular focus on the role of cognitive speed. Method. In this study, 28 patients with PD completed measures of verbal fluency, motivation, language, executive functioning, and speed of processing, before and after DBS. Results. As expected, there was a marked decline in verbal fluency but also in a timed test of executive functions and two measures of speed of processing. Verbal fluency decline was associated with markers of linguistic and executive functioning, but not after speed of processing was statistically controlled for. In contrast, greater decline in verbal fluency was associated with higher levels of apathy at baseline, which was not associated with changes in cognitive speed. Discussion. Reduced generativity and processing speed may account for the marked reduction in verbal fluency commonly observed following DBS. |
| format | Article |
| id | doaj-art-4f4cf02eac7c4935a70a9bc2b71b31cf |
| institution | DOAJ |
| issn | 0953-4180 1875-8584 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Behavioural Neurology |
| spelling | doaj-art-4f4cf02eac7c4935a70a9bc2b71b31cf2025-08-20T03:20:18ZengWileyBehavioural Neurology0953-41801875-85842017-01-01201710.1155/2017/73481017348101Apathy and Reduced Speed of Processing Underlie Decline in Verbal Fluency following DBSJennifer A. Foley0Tom Foltynie1Ludvic Zrinzo2Jonathan A. Hyam3Patricia Limousin4Lisa Cipolotti5National Hospital for Neurology and Neurosurgery, Queen Square, London, UKNational Hospital for Neurology and Neurosurgery, Queen Square, London, UKNational Hospital for Neurology and Neurosurgery, Queen Square, London, UKNational Hospital for Neurology and Neurosurgery, Queen Square, London, UKNational Hospital for Neurology and Neurosurgery, Queen Square, London, UKNational Hospital for Neurology and Neurosurgery, Queen Square, London, UKObjective. Reduced verbal fluency is a strikingly uniform finding following deep brain stimulation (DBS) for Parkinson’s disease (PD). The precise cognitive mechanism underlying this reduction remains unclear, but theories have suggested reduced motivation, linguistic skill, and/or executive function. It is of note, however, that previous reports have failed to consider the potential role of any changes in speed of processing. Thus, the aim of this study was to examine verbal fluency changes with a particular focus on the role of cognitive speed. Method. In this study, 28 patients with PD completed measures of verbal fluency, motivation, language, executive functioning, and speed of processing, before and after DBS. Results. As expected, there was a marked decline in verbal fluency but also in a timed test of executive functions and two measures of speed of processing. Verbal fluency decline was associated with markers of linguistic and executive functioning, but not after speed of processing was statistically controlled for. In contrast, greater decline in verbal fluency was associated with higher levels of apathy at baseline, which was not associated with changes in cognitive speed. Discussion. Reduced generativity and processing speed may account for the marked reduction in verbal fluency commonly observed following DBS.http://dx.doi.org/10.1155/2017/7348101 |
| spellingShingle | Jennifer A. Foley Tom Foltynie Ludvic Zrinzo Jonathan A. Hyam Patricia Limousin Lisa Cipolotti Apathy and Reduced Speed of Processing Underlie Decline in Verbal Fluency following DBS Behavioural Neurology |
| title | Apathy and Reduced Speed of Processing Underlie Decline in Verbal Fluency following DBS |
| title_full | Apathy and Reduced Speed of Processing Underlie Decline in Verbal Fluency following DBS |
| title_fullStr | Apathy and Reduced Speed of Processing Underlie Decline in Verbal Fluency following DBS |
| title_full_unstemmed | Apathy and Reduced Speed of Processing Underlie Decline in Verbal Fluency following DBS |
| title_short | Apathy and Reduced Speed of Processing Underlie Decline in Verbal Fluency following DBS |
| title_sort | apathy and reduced speed of processing underlie decline in verbal fluency following dbs |
| url | http://dx.doi.org/10.1155/2017/7348101 |
| work_keys_str_mv | AT jenniferafoley apathyandreducedspeedofprocessingunderliedeclineinverbalfluencyfollowingdbs AT tomfoltynie apathyandreducedspeedofprocessingunderliedeclineinverbalfluencyfollowingdbs AT ludviczrinzo apathyandreducedspeedofprocessingunderliedeclineinverbalfluencyfollowingdbs AT jonathanahyam apathyandreducedspeedofprocessingunderliedeclineinverbalfluencyfollowingdbs AT patricialimousin apathyandreducedspeedofprocessingunderliedeclineinverbalfluencyfollowingdbs AT lisacipolotti apathyandreducedspeedofprocessingunderliedeclineinverbalfluencyfollowingdbs |