Clinical characteristics of megaloblastic anemia with pancytopenia
Objectives In this study, we aimed to explore the clinical characteristics of patients with megaloblastic anemia and pancytopenia.Methods Data on patient characteristics, laboratory examinations, clinical manifestations, and associated diseases were collected from Changzhou Hospital of Traditional C...
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Taylor & Francis Group
2024-12-01
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| Series: | Hematology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/16078454.2024.2420407 |
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| author | Lin Tang Jing Miao Jinbi Wang |
| author_facet | Lin Tang Jing Miao Jinbi Wang |
| author_sort | Lin Tang |
| collection | DOAJ |
| description | Objectives In this study, we aimed to explore the clinical characteristics of patients with megaloblastic anemia and pancytopenia.Methods Data on patient characteristics, laboratory examinations, clinical manifestations, and associated diseases were collected from Changzhou Hospital of Traditional Chinese Medicine. The participants were divided into two groups according to routine blood test results: megaloblastic anemia patients with pancytopenia (Group A) and megaloblastic anemia patients with simple anemia (Group B).Results The number of patients with fever and bleeding in Group A was much higher than that in Group B. Inpatient days and hospitalization costs in Group A were higher than those in Group B. White blood cell count, red blood cell count, haemoglobin level, and platelet count in Group A were lower than those in Group B. There were no significant differences in mean corpuscular volume (MCV), mean corpuscular haemoglobin (MCH), and serum levels of lactate dehydrogenase (LDH), total bilirubin (TBIL), direct bilirubin (DBIL), indirect bilirubin (IBIL), albumin (ALB), vitamin B12, folic acid, and ferritin between the two groups. The incidence of associated diseases, particularly pulmonary infections, was significantly higher in Group A than in Group B. There was no significant difference in the degree of bone marrow hyperplasia between the two groups.Conclusion Patients with pancytopenia and megaloblastic anemia often developed infection and bleeding, which caused more severe anemia, higher hospitalization costs, and longer inpatient days. Early diagnosis and active treatment are required to reduce patient complications and costs. |
| format | Article |
| id | doaj-art-4f4b2c7b183946d494c5be4c74957be4 |
| institution | OA Journals |
| issn | 1607-8454 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Hematology |
| spelling | doaj-art-4f4b2c7b183946d494c5be4c74957be42025-08-20T01:59:10ZengTaylor & Francis GroupHematology1607-84542024-12-0129110.1080/16078454.2024.2420407Clinical characteristics of megaloblastic anemia with pancytopeniaLin Tang0Jing Miao1Jinbi Wang2Department of Hematology, Changzhou Hospital of Traditional Chinese Medicine, Changzhou, People’s Republic of ChinaDepartment of Hematology, Changzhou Hospital of Traditional Chinese Medicine, Changzhou, People’s Republic of ChinaDepartment of Hematology, Changzhou Hospital of Traditional Chinese Medicine, Changzhou, People’s Republic of ChinaObjectives In this study, we aimed to explore the clinical characteristics of patients with megaloblastic anemia and pancytopenia.Methods Data on patient characteristics, laboratory examinations, clinical manifestations, and associated diseases were collected from Changzhou Hospital of Traditional Chinese Medicine. The participants were divided into two groups according to routine blood test results: megaloblastic anemia patients with pancytopenia (Group A) and megaloblastic anemia patients with simple anemia (Group B).Results The number of patients with fever and bleeding in Group A was much higher than that in Group B. Inpatient days and hospitalization costs in Group A were higher than those in Group B. White blood cell count, red blood cell count, haemoglobin level, and platelet count in Group A were lower than those in Group B. There were no significant differences in mean corpuscular volume (MCV), mean corpuscular haemoglobin (MCH), and serum levels of lactate dehydrogenase (LDH), total bilirubin (TBIL), direct bilirubin (DBIL), indirect bilirubin (IBIL), albumin (ALB), vitamin B12, folic acid, and ferritin between the two groups. The incidence of associated diseases, particularly pulmonary infections, was significantly higher in Group A than in Group B. There was no significant difference in the degree of bone marrow hyperplasia between the two groups.Conclusion Patients with pancytopenia and megaloblastic anemia often developed infection and bleeding, which caused more severe anemia, higher hospitalization costs, and longer inpatient days. Early diagnosis and active treatment are required to reduce patient complications and costs.https://www.tandfonline.com/doi/10.1080/16078454.2024.2420407Megaloblastic anemiapancytopeniavitamin B12folic acidbone marrow hyperplasiainpatient days |
| spellingShingle | Lin Tang Jing Miao Jinbi Wang Clinical characteristics of megaloblastic anemia with pancytopenia Hematology Megaloblastic anemia pancytopenia vitamin B12 folic acid bone marrow hyperplasia inpatient days |
| title | Clinical characteristics of megaloblastic anemia with pancytopenia |
| title_full | Clinical characteristics of megaloblastic anemia with pancytopenia |
| title_fullStr | Clinical characteristics of megaloblastic anemia with pancytopenia |
| title_full_unstemmed | Clinical characteristics of megaloblastic anemia with pancytopenia |
| title_short | Clinical characteristics of megaloblastic anemia with pancytopenia |
| title_sort | clinical characteristics of megaloblastic anemia with pancytopenia |
| topic | Megaloblastic anemia pancytopenia vitamin B12 folic acid bone marrow hyperplasia inpatient days |
| url | https://www.tandfonline.com/doi/10.1080/16078454.2024.2420407 |
| work_keys_str_mv | AT lintang clinicalcharacteristicsofmegaloblasticanemiawithpancytopenia AT jingmiao clinicalcharacteristicsofmegaloblasticanemiawithpancytopenia AT jinbiwang clinicalcharacteristicsofmegaloblasticanemiawithpancytopenia |