Modulating mitochondria with natural extract compounds: from bench to clinical therapeutic opportunities for COPD
Chronic obstructive pulmonary disease (COPD) is a chronic respiratory disease that leads to death and disability worldwide, and it is caused by hereditary and environmental factors. It is characterized by chronic inflammation, emphysema, and irreversible limitation of airflow. Dual or triple therapy...
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1531302/full |
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| author | Qiao Wang Ziling Zeng Linlin Guo Kent E. Williams Yun Zhang Yun Zhang Hongmei Tang Hang Hu Hang Hu Gang Qin Kaijin Wang Xing Wang |
| author_facet | Qiao Wang Ziling Zeng Linlin Guo Kent E. Williams Yun Zhang Yun Zhang Hongmei Tang Hang Hu Hang Hu Gang Qin Kaijin Wang Xing Wang |
| author_sort | Qiao Wang |
| collection | DOAJ |
| description | Chronic obstructive pulmonary disease (COPD) is a chronic respiratory disease that leads to death and disability worldwide, and it is caused by hereditary and environmental factors. It is characterized by chronic inflammation, emphysema, and irreversible limitation of airflow. Dual or triple therapy with a traditional approach can provide relief from COPD symptoms by reducing the frequency and severity of the outbreaks, but there are no current therapies to reverse the long-term decline in lung function. Although ICS rescue inhalers demonstrate efficacy in acute attacks, these cannot be utilized for chronic management of COPD due to adverse effects. Therefore, novel agents and therapeutic strategies are urgently needed to address this disease. It is believed that malfunctioning mitochondria are associated with COPD pathogenesis, contributing to inflammation, apoptosis, and cellular senescence. A better understanding of these mechanisms could provide novel therapeutic approaches for maintaining lung and skeletal muscle function. Many natural extract compounds show therapeutic potential for COPD and are associated with few adverse reactions. Notably, these natural compounds can improve mitochondrial function and exhibit a variety of anti-inflammatory, antioxidant, and immunomodulatory properties. In this review, we systemically summarize the pathogenic role of impaired mitochondria in COPD and the potential mechanisms by which natural extract compounds may ameliorate these impairments. |
| format | Article |
| id | doaj-art-4f4af7648bf54758b62bfcb59dfc683a |
| institution | OA Journals |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-4f4af7648bf54758b62bfcb59dfc683a2025-08-20T01:55:21ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-05-011610.3389/fphar.2025.15313021531302Modulating mitochondria with natural extract compounds: from bench to clinical therapeutic opportunities for COPDQiao Wang0Ziling Zeng1Linlin Guo2Kent E. Williams3Yun Zhang4Yun Zhang5Hongmei Tang6Hang Hu7Hang Hu8Gang Qin9Kaijin Wang10Xing Wang11Inflammation & Allergic Diseases Research Unit, The Affiliated Hospital of Southwest Medical University, Luzhou, ChinaInflammation & Allergic Diseases Research Unit, The Affiliated Hospital of Southwest Medical University, Luzhou, ChinaDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, United StatesIndiana University School of Medicine, Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, IN, United StatesInflammation & Allergic Diseases Research Unit, The Affiliated Hospital of Southwest Medical University, Luzhou, ChinaDepartment of Respiratory and Critical Care Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, ChinaInflammation & Allergic Diseases Research Unit, The Affiliated Hospital of Southwest Medical University, Luzhou, ChinaDepartment of Respiratory and Critical Care Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, ChinaDepartment of Respiratory and Critical Care Medicine, Bishan Hospital of Chongqing, Bishan Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Otolaryngology Head and Neck Surgery, The Affiliated Hospital of Southwest Medical University, Luzhou, ChinaDepartment of Respiratory and Critical Care Medicine, Bishan Hospital of Chongqing, Bishan Hospital of Chongqing Medical University, Chongqing, ChinaInflammation & Allergic Diseases Research Unit, The Affiliated Hospital of Southwest Medical University, Luzhou, ChinaChronic obstructive pulmonary disease (COPD) is a chronic respiratory disease that leads to death and disability worldwide, and it is caused by hereditary and environmental factors. It is characterized by chronic inflammation, emphysema, and irreversible limitation of airflow. Dual or triple therapy with a traditional approach can provide relief from COPD symptoms by reducing the frequency and severity of the outbreaks, but there are no current therapies to reverse the long-term decline in lung function. Although ICS rescue inhalers demonstrate efficacy in acute attacks, these cannot be utilized for chronic management of COPD due to adverse effects. Therefore, novel agents and therapeutic strategies are urgently needed to address this disease. It is believed that malfunctioning mitochondria are associated with COPD pathogenesis, contributing to inflammation, apoptosis, and cellular senescence. A better understanding of these mechanisms could provide novel therapeutic approaches for maintaining lung and skeletal muscle function. Many natural extract compounds show therapeutic potential for COPD and are associated with few adverse reactions. Notably, these natural compounds can improve mitochondrial function and exhibit a variety of anti-inflammatory, antioxidant, and immunomodulatory properties. In this review, we systemically summarize the pathogenic role of impaired mitochondria in COPD and the potential mechanisms by which natural extract compounds may ameliorate these impairments.https://www.frontiersin.org/articles/10.3389/fphar.2025.1531302/fullMitochondriamtROScigarette smokelung diseasenatural extract compoundCOPD |
| spellingShingle | Qiao Wang Ziling Zeng Linlin Guo Kent E. Williams Yun Zhang Yun Zhang Hongmei Tang Hang Hu Hang Hu Gang Qin Kaijin Wang Xing Wang Modulating mitochondria with natural extract compounds: from bench to clinical therapeutic opportunities for COPD Frontiers in Pharmacology Mitochondria mtROS cigarette smoke lung disease natural extract compound COPD |
| title | Modulating mitochondria with natural extract compounds: from bench to clinical therapeutic opportunities for COPD |
| title_full | Modulating mitochondria with natural extract compounds: from bench to clinical therapeutic opportunities for COPD |
| title_fullStr | Modulating mitochondria with natural extract compounds: from bench to clinical therapeutic opportunities for COPD |
| title_full_unstemmed | Modulating mitochondria with natural extract compounds: from bench to clinical therapeutic opportunities for COPD |
| title_short | Modulating mitochondria with natural extract compounds: from bench to clinical therapeutic opportunities for COPD |
| title_sort | modulating mitochondria with natural extract compounds from bench to clinical therapeutic opportunities for copd |
| topic | Mitochondria mtROS cigarette smoke lung disease natural extract compound COPD |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1531302/full |
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