Genetic characteristics and potential pathogenic agents in Campylobacter upsaliensis based on genomic analysis
Campylobacter upsaliensis was the most common Campylobacter species in pets’ gastrointestinal tracts and has been isolated from patients with bacteremia, hemolytic-uremic syndrome, spontaneous abortion, and Guillain-Barré syndrome. However, the genetic characteristics and the full extent of its sign...
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Taylor & Francis Group
2024-12-01
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| Series: | Emerging Microbes and Infections |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/22221751.2023.2294857 |
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| author | Hairui Wang Yixin Gu Changyan Ju Ying Li Xiaoli Chen Guilan Zhou Xin Zhang Chang Liu Jing Chen Yue Han Jianzhong Zhang Zhujun Shao Maojun Zhang |
| author_facet | Hairui Wang Yixin Gu Changyan Ju Ying Li Xiaoli Chen Guilan Zhou Xin Zhang Chang Liu Jing Chen Yue Han Jianzhong Zhang Zhujun Shao Maojun Zhang |
| author_sort | Hairui Wang |
| collection | DOAJ |
| description | Campylobacter upsaliensis was the most common Campylobacter species in pets’ gastrointestinal tracts and has been isolated from patients with bacteremia, hemolytic-uremic syndrome, spontaneous abortion, and Guillain-Barré syndrome. However, the genetic characteristics and the full extent of its significance as a human pathogen remain to be fully understood. This study involved an investigation for genomic analysis of 154 strains from different sources and additional antimicrobial resistance profiles of 26 strains for this species. The genomes contained 1,558–1,971 CDS and the genome sizes were estimated to vary from 1.53 Mb to 1.86 Mb, with an average GC content of 34.71%. The entire analyzed genomes could be divided into three clades (A, B, and C) based on ANI and phylogenomic analysis. Significantly, nearly all strains in Clade B were isolated from patient samples, and the virulence-related sequences FlgD, GmhA, and CdtC might serve as determining factors for the classification of Clade B. Half of the tested isolates had MIC values over 64 μg mL−1 for nalidixic acid, gentamicin, and streptomycin. Isolates from pets in China carried more resistant elements in the genomes. This study both provided a comprehensive profile of C. upsaliensis for its genomic features and suggested some pathogenic agents for human infection with this species. |
| format | Article |
| id | doaj-art-4f49ff179d2b4fcea67dbe38b4341af4 |
| institution | OA Journals |
| issn | 2222-1751 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Emerging Microbes and Infections |
| spelling | doaj-art-4f49ff179d2b4fcea67dbe38b4341af42025-08-20T02:37:32ZengTaylor & Francis GroupEmerging Microbes and Infections2222-17512024-12-0113110.1080/22221751.2023.2294857Genetic characteristics and potential pathogenic agents in Campylobacter upsaliensis based on genomic analysisHairui Wang0Yixin Gu1Changyan Ju2Ying Li3Xiaoli Chen4Guilan Zhou5Xin Zhang6Chang Liu7Jing Chen8Yue Han9Jianzhong Zhang10Zhujun Shao11Maojun Zhang12National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People’s Republic of ChinaNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People’s Republic of ChinaNanshan Center for Disease Control and Prevention, Shenzhen, People’s Republic of ChinaShunyi District Center for Disease Control and Prevention, Beijing, People’s Republic of ChinaNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People’s Republic of ChinaNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People’s Republic of ChinaNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People’s Republic of ChinaNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People’s Republic of ChinaMeilianzhonghe Veterinary Hospital Companion Branch, Beijing, People’s Republic of ChinaMeilianzhonghe Veterinary Hospital Jingxi Branch, Beijing, People’s Republic of ChinaNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People’s Republic of ChinaNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People’s Republic of ChinaNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People’s Republic of ChinaCampylobacter upsaliensis was the most common Campylobacter species in pets’ gastrointestinal tracts and has been isolated from patients with bacteremia, hemolytic-uremic syndrome, spontaneous abortion, and Guillain-Barré syndrome. However, the genetic characteristics and the full extent of its significance as a human pathogen remain to be fully understood. This study involved an investigation for genomic analysis of 154 strains from different sources and additional antimicrobial resistance profiles of 26 strains for this species. The genomes contained 1,558–1,971 CDS and the genome sizes were estimated to vary from 1.53 Mb to 1.86 Mb, with an average GC content of 34.71%. The entire analyzed genomes could be divided into three clades (A, B, and C) based on ANI and phylogenomic analysis. Significantly, nearly all strains in Clade B were isolated from patient samples, and the virulence-related sequences FlgD, GmhA, and CdtC might serve as determining factors for the classification of Clade B. Half of the tested isolates had MIC values over 64 μg mL−1 for nalidixic acid, gentamicin, and streptomycin. Isolates from pets in China carried more resistant elements in the genomes. This study both provided a comprehensive profile of C. upsaliensis for its genomic features and suggested some pathogenic agents for human infection with this species.https://www.tandfonline.com/doi/10.1080/22221751.2023.2294857Campylobacter upsaliensispathogenic agentcomparative genomicsvirulence factorantimicrobial resistance |
| spellingShingle | Hairui Wang Yixin Gu Changyan Ju Ying Li Xiaoli Chen Guilan Zhou Xin Zhang Chang Liu Jing Chen Yue Han Jianzhong Zhang Zhujun Shao Maojun Zhang Genetic characteristics and potential pathogenic agents in Campylobacter upsaliensis based on genomic analysis Emerging Microbes and Infections Campylobacter upsaliensis pathogenic agent comparative genomics virulence factor antimicrobial resistance |
| title | Genetic characteristics and potential pathogenic agents in Campylobacter upsaliensis based on genomic analysis |
| title_full | Genetic characteristics and potential pathogenic agents in Campylobacter upsaliensis based on genomic analysis |
| title_fullStr | Genetic characteristics and potential pathogenic agents in Campylobacter upsaliensis based on genomic analysis |
| title_full_unstemmed | Genetic characteristics and potential pathogenic agents in Campylobacter upsaliensis based on genomic analysis |
| title_short | Genetic characteristics and potential pathogenic agents in Campylobacter upsaliensis based on genomic analysis |
| title_sort | genetic characteristics and potential pathogenic agents in campylobacter upsaliensis based on genomic analysis |
| topic | Campylobacter upsaliensis pathogenic agent comparative genomics virulence factor antimicrobial resistance |
| url | https://www.tandfonline.com/doi/10.1080/22221751.2023.2294857 |
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