Tumoroid Model Reveals Synergistic Impairment of Metabolism by Iron Chelators and Temozolomide in Chemo‐Resistant Patient‐derived Glioblastoma Cells

Tumoroid Model Reveals Synergistic Impairment of Metabolism by Iron Chelators and Temozolomide in Chemo‐Resistant Patient‐derived Glioblastoma Cells

Abstract Chemoresistance poses a significant clinical challenge in managing glioblastoma (GBM), limiting the long‐term success of traditional treatments. Here, a 3D tumoroid model is used to investigate the metabolic sensitivity of temozolomide (TMZ)‐resistant GBM cells to iron chelation by deferoxa...

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Bibliographic Details
Main Authors: Meitham Amereh, Amir Seyfoori, Shahla Shojaei, Sarah Lane, Tian Zhao, Mahdieh Shokrollahi Barough, Julian J. Lum, Patrick B. Walter, Mohsen Akbari
Format: Article
Language:English
Published: Wiley 2025-05-01
Series:Advanced Science
Subjects:
chemoresistance
glioblastoma
iron metabolism
metabolic sensitivity
tumoroid model
Online Access:https://doi.org/10.1002/advs.202412505
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