OSMR induces M2 polarization of glioblastoma associated macrophages through JAK/STAT3 signaling pathway

OSMR induces M2 polarization of glioblastoma associated macrophages through JAK/STAT3 signaling pathway

IntroductionVerify whether Onconstatin M receptor (OSMR) plays a regulatory role in the growth of glioblastoma (GBM) and explore its specific regulatory mechanism.MethodsIn vitro investigations were carried out using OSMR knockdown and treatment with JAK agonist Butyzamide (JAKa). Evaluate cell prol...

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Bibliographic Details
Main Authors: Changcheng Xiao, Liming Tan, Xiaofei Liu, Min Zhou, Ping Chen, Zhao Wang, Bing Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Oncology
Subjects:
OSMR
glioblastoma
JAK/STAT3 signaling pathway
macrophage
M2 polarization
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1538649/full
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