The contributions of T cell-mediated immunity to protection from vaccine-preventable diseases: A primer
In the face of the ever-present burden of emerging and reemerging infectious diseases, there is a growing need to comprehensively assess individual- and population-level immunity to vaccine-preventable diseases (VPDs). Many of these efforts, however, focus exclusively on antibody-mediated immunity,...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Human Vaccines & Immunotherapeutics |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/21645515.2024.2395679 |
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| author | Janna R. Shapiro Mario Corrado Julie Perry Tania H. Watts Shelly Bolotin |
| author_facet | Janna R. Shapiro Mario Corrado Julie Perry Tania H. Watts Shelly Bolotin |
| author_sort | Janna R. Shapiro |
| collection | DOAJ |
| description | In the face of the ever-present burden of emerging and reemerging infectious diseases, there is a growing need to comprehensively assess individual- and population-level immunity to vaccine-preventable diseases (VPDs). Many of these efforts, however, focus exclusively on antibody-mediated immunity, ignoring the role of T cells. Aimed at clinicians, public health practioners, and others who play central roles in human vaccine research but do not have formal training in immunology, we review how vaccines against infectious diseases elicit T cell responses, what types of vaccines elicit T cell responses, and how T cell responses are measured. We then use examples to demonstrate six ways that T cells contribute to protection from VPD, including directly mediating protection, enabling antibody responses, reducing disease severity, increasing cross-reactivity, improving durability, and protecting special populations. We conclude with a discussion of challenges and solutions to more widespread consideration of T cell responses in clinical vaccinology. |
| format | Article |
| id | doaj-art-4f44dd7efce44d47a82d7bfc48fa6aef |
| institution | DOAJ |
| issn | 2164-5515 2164-554X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj-art-4f44dd7efce44d47a82d7bfc48fa6aef2025-08-20T03:21:46ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2024-12-0120110.1080/21645515.2024.2395679The contributions of T cell-mediated immunity to protection from vaccine-preventable diseases: A primerJanna R. Shapiro0Mario Corrado1Julie Perry2Tania H. Watts3Shelly Bolotin4Department of Immunology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, CanadaDivision of General Internal Medicine, University of Toronto, Toronto, ON, CanadaCenter for Vaccine Preventable Diseases, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, CanadaDepartment of Immunology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, CanadaCenter for Vaccine Preventable Diseases, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, CanadaIn the face of the ever-present burden of emerging and reemerging infectious diseases, there is a growing need to comprehensively assess individual- and population-level immunity to vaccine-preventable diseases (VPDs). Many of these efforts, however, focus exclusively on antibody-mediated immunity, ignoring the role of T cells. Aimed at clinicians, public health practioners, and others who play central roles in human vaccine research but do not have formal training in immunology, we review how vaccines against infectious diseases elicit T cell responses, what types of vaccines elicit T cell responses, and how T cell responses are measured. We then use examples to demonstrate six ways that T cells contribute to protection from VPD, including directly mediating protection, enabling antibody responses, reducing disease severity, increasing cross-reactivity, improving durability, and protecting special populations. We conclude with a discussion of challenges and solutions to more widespread consideration of T cell responses in clinical vaccinology.https://www.tandfonline.com/doi/10.1080/21645515.2024.2395679Vaccinescell-mediated immunityCD4 T cellsCD8 T cellsimmunogenicityvaccine-preventable diseases |
| spellingShingle | Janna R. Shapiro Mario Corrado Julie Perry Tania H. Watts Shelly Bolotin The contributions of T cell-mediated immunity to protection from vaccine-preventable diseases: A primer Human Vaccines & Immunotherapeutics Vaccines cell-mediated immunity CD4 T cells CD8 T cells immunogenicity vaccine-preventable diseases |
| title | The contributions of T cell-mediated immunity to protection from vaccine-preventable diseases: A primer |
| title_full | The contributions of T cell-mediated immunity to protection from vaccine-preventable diseases: A primer |
| title_fullStr | The contributions of T cell-mediated immunity to protection from vaccine-preventable diseases: A primer |
| title_full_unstemmed | The contributions of T cell-mediated immunity to protection from vaccine-preventable diseases: A primer |
| title_short | The contributions of T cell-mediated immunity to protection from vaccine-preventable diseases: A primer |
| title_sort | contributions of t cell mediated immunity to protection from vaccine preventable diseases a primer |
| topic | Vaccines cell-mediated immunity CD4 T cells CD8 T cells immunogenicity vaccine-preventable diseases |
| url | https://www.tandfonline.com/doi/10.1080/21645515.2024.2395679 |
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