Case Report: combined surgical and pharmacological management of basal ganglia cryptococcal meningoencephalitis
IntroductionCryptococcal meningoencephalitis involving the basal ganglia is exceedingly rare and poses diagnostic and therapeutic challenges due to its tumor-mimicking presentation. This case underscores the necessity of a multidisciplinary approach integrating surgical intervention and targeted ant...
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| Format: | Article |
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Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1601269/full |
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| author | Xiao-Yu Zheng Ping Chen Dong-Yue Li Ke-En Chen Jian-Cheng Liao Meng-Hui Li Mao-Ying Zhang |
| author_facet | Xiao-Yu Zheng Ping Chen Dong-Yue Li Ke-En Chen Jian-Cheng Liao Meng-Hui Li Mao-Ying Zhang |
| author_sort | Xiao-Yu Zheng |
| collection | DOAJ |
| description | IntroductionCryptococcal meningoencephalitis involving the basal ganglia is exceedingly rare and poses diagnostic and therapeutic challenges due to its tumor-mimicking presentation. This case underscores the necessity of a multidisciplinary approach integrating surgical intervention and targeted antifungal therapy.Case presentationA 47-years-old immunocompetent female presented with progressive headache and left-sided hemiparesis. Neuroimaging identified a basal ganglia mass initially misdiagnosed as a neoplastic lesion.InterventionsSurgical resection under neuroelectrophysiological monitoring was combined with amphotericin B, flucytosine, and fluconazole.OutcomesComplete lesion excision, symptom resolution, and mild memory deficits at 4-years follow-up.LessonsCombined therapy is pivotal for CM with parenchymal involvement; early surgery may mitigate irreversible neurological sequelae. |
| format | Article |
| id | doaj-art-4f43d2432e194983abfc5e38f8e591cf |
| institution | DOAJ |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-4f43d2432e194983abfc5e38f8e591cf2025-08-20T02:57:16ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-08-011210.3389/fmed.2025.16012691601269Case Report: combined surgical and pharmacological management of basal ganglia cryptococcal meningoencephalitisXiao-Yu Zheng0Ping Chen1Dong-Yue Li2Ke-En Chen3Jian-Cheng Liao4Meng-Hui Li5Mao-Ying Zhang6Department of Intensive-Care Unit, The First Affiliated Hospital of Jinan University, Guangzhou, ChinaDepartment of Intensive-Care Unit, The First Affiliated Hospital of Jinan University, Guangzhou, ChinaDepartment of Neurosurgery, The First Affiliated Hospital of Jinan University, Guangzhou, ChinaDepartment of Neurosurgery, The First Affiliated Hospital of Jinan University, Guangzhou, ChinaDepartment of Neurosurgery, The First Affiliated Hospital of Jinan University, Guangzhou, ChinaDepartment of Neurosurgery, The First Affiliated Hospital of Jinan University, Guangzhou, ChinaDepartment of Intensive-Care Unit, The First Affiliated Hospital of Jinan University, Guangzhou, ChinaIntroductionCryptococcal meningoencephalitis involving the basal ganglia is exceedingly rare and poses diagnostic and therapeutic challenges due to its tumor-mimicking presentation. This case underscores the necessity of a multidisciplinary approach integrating surgical intervention and targeted antifungal therapy.Case presentationA 47-years-old immunocompetent female presented with progressive headache and left-sided hemiparesis. Neuroimaging identified a basal ganglia mass initially misdiagnosed as a neoplastic lesion.InterventionsSurgical resection under neuroelectrophysiological monitoring was combined with amphotericin B, flucytosine, and fluconazole.OutcomesComplete lesion excision, symptom resolution, and mild memory deficits at 4-years follow-up.LessonsCombined therapy is pivotal for CM with parenchymal involvement; early surgery may mitigate irreversible neurological sequelae.https://www.frontiersin.org/articles/10.3389/fmed.2025.1601269/fullcryptococcal meningoencephalitisbasal gangliacombined therapycase reportneurosurgical intervention |
| spellingShingle | Xiao-Yu Zheng Ping Chen Dong-Yue Li Ke-En Chen Jian-Cheng Liao Meng-Hui Li Mao-Ying Zhang Case Report: combined surgical and pharmacological management of basal ganglia cryptococcal meningoencephalitis Frontiers in Medicine cryptococcal meningoencephalitis basal ganglia combined therapy case report neurosurgical intervention |
| title | Case Report: combined surgical and pharmacological management of basal ganglia cryptococcal meningoencephalitis |
| title_full | Case Report: combined surgical and pharmacological management of basal ganglia cryptococcal meningoencephalitis |
| title_fullStr | Case Report: combined surgical and pharmacological management of basal ganglia cryptococcal meningoencephalitis |
| title_full_unstemmed | Case Report: combined surgical and pharmacological management of basal ganglia cryptococcal meningoencephalitis |
| title_short | Case Report: combined surgical and pharmacological management of basal ganglia cryptococcal meningoencephalitis |
| title_sort | case report combined surgical and pharmacological management of basal ganglia cryptococcal meningoencephalitis |
| topic | cryptococcal meningoencephalitis basal ganglia combined therapy case report neurosurgical intervention |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1601269/full |
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