Case Report: combined surgical and pharmacological management of basal ganglia cryptococcal meningoencephalitis
IntroductionCryptococcal meningoencephalitis involving the basal ganglia is exceedingly rare and poses diagnostic and therapeutic challenges due to its tumor-mimicking presentation. This case underscores the necessity of a multidisciplinary approach integrating surgical intervention and targeted ant...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1601269/full |
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| Summary: | IntroductionCryptococcal meningoencephalitis involving the basal ganglia is exceedingly rare and poses diagnostic and therapeutic challenges due to its tumor-mimicking presentation. This case underscores the necessity of a multidisciplinary approach integrating surgical intervention and targeted antifungal therapy.Case presentationA 47-years-old immunocompetent female presented with progressive headache and left-sided hemiparesis. Neuroimaging identified a basal ganglia mass initially misdiagnosed as a neoplastic lesion.InterventionsSurgical resection under neuroelectrophysiological monitoring was combined with amphotericin B, flucytosine, and fluconazole.OutcomesComplete lesion excision, symptom resolution, and mild memory deficits at 4-years follow-up.LessonsCombined therapy is pivotal for CM with parenchymal involvement; early surgery may mitigate irreversible neurological sequelae. |
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| ISSN: | 2296-858X |