Big lessons from the little Akkermansia muciniphila in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is the most frequently occurring type of liver tumor and is considered one of the most common primary malignant neoplasms. The prognosis for HCC is dismal because of its complicated etiology and high level of medication resistance. Immunotherapy is presently regarded a...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-02-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1524563/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849721753419382784 |
|---|---|
| author | Yanguang Yang Yanguang Yang Xinli Shi Xinli Shi |
| author_facet | Yanguang Yang Yanguang Yang Xinli Shi Xinli Shi |
| author_sort | Yanguang Yang |
| collection | DOAJ |
| description | Hepatocellular carcinoma (HCC) is the most frequently occurring type of liver tumor and is considered one of the most common primary malignant neoplasms. The prognosis for HCC is dismal because of its complicated etiology and high level of medication resistance. Immunotherapy is presently regarded as one of the most effective therapeutic options for HCC; nevertheless, because of the disturbance of intestinal flora, immunotherapy shows low antitumor efficacy. An increasing body of research indicates that intestinal flora, particularly Akkermansia muciniphila (A. muciniphila), is vital for the treatment of tumors. Studies have demonstrated that the diminished effectiveness of immunotherapy in cancer patients is associated with a reduction in A. muciniphila levels, suggesting that increasing A. muciniphila levels significantly enhance the efficacy of immunotherapy. A. muciniphila functions as a gut probiotic and can treat and prevent a wide range of illnesses, including cancer. Consequently, preserving A. muciniphila abundance is enough to prevent and lower the danger of developing cancer disorders. In this review, we critically evaluate the current body of research on A. muciniphila, with a primary focus on its biological properties and functions. The different illnesses that A. muciniphila treats were then discussed, particularly the way it works with liver cancer. This review aims to give a novel treatment plan for patients with HCC as well as a theoretical foundation for improving HCC immunotherapy. |
| format | Article |
| id | doaj-art-4f3a98b148ac4bfa81cfd5463735b0a8 |
| institution | DOAJ |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-4f3a98b148ac4bfa81cfd5463735b0a82025-08-20T03:11:33ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-02-011610.3389/fimmu.2025.15245631524563Big lessons from the little Akkermansia muciniphila in hepatocellular carcinomaYanguang Yang0Yanguang Yang1Xinli Shi2Xinli Shi3Laboratory of Integrated Medicine Tumor Immunology, Shanxi University of Chinese Medicine, Taiyuan, ChinaDepartment of Pathobiology and Immunology, Hebei University of Chinese Medicine, Shijiazhuang, ChinaLaboratory of Integrated Medicine Tumor Immunology, Shanxi University of Chinese Medicine, Taiyuan, ChinaDepartment of Pathobiology and Immunology, Hebei University of Chinese Medicine, Shijiazhuang, ChinaHepatocellular carcinoma (HCC) is the most frequently occurring type of liver tumor and is considered one of the most common primary malignant neoplasms. The prognosis for HCC is dismal because of its complicated etiology and high level of medication resistance. Immunotherapy is presently regarded as one of the most effective therapeutic options for HCC; nevertheless, because of the disturbance of intestinal flora, immunotherapy shows low antitumor efficacy. An increasing body of research indicates that intestinal flora, particularly Akkermansia muciniphila (A. muciniphila), is vital for the treatment of tumors. Studies have demonstrated that the diminished effectiveness of immunotherapy in cancer patients is associated with a reduction in A. muciniphila levels, suggesting that increasing A. muciniphila levels significantly enhance the efficacy of immunotherapy. A. muciniphila functions as a gut probiotic and can treat and prevent a wide range of illnesses, including cancer. Consequently, preserving A. muciniphila abundance is enough to prevent and lower the danger of developing cancer disorders. In this review, we critically evaluate the current body of research on A. muciniphila, with a primary focus on its biological properties and functions. The different illnesses that A. muciniphila treats were then discussed, particularly the way it works with liver cancer. This review aims to give a novel treatment plan for patients with HCC as well as a theoretical foundation for improving HCC immunotherapy.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1524563/fullhepatocellular carcinomaAkkermansia muciniphilaimmunotherapytraditional Chinese medicineintestinal flora |
| spellingShingle | Yanguang Yang Yanguang Yang Xinli Shi Xinli Shi Big lessons from the little Akkermansia muciniphila in hepatocellular carcinoma Frontiers in Immunology hepatocellular carcinoma Akkermansia muciniphila immunotherapy traditional Chinese medicine intestinal flora |
| title | Big lessons from the little Akkermansia muciniphila in hepatocellular carcinoma |
| title_full | Big lessons from the little Akkermansia muciniphila in hepatocellular carcinoma |
| title_fullStr | Big lessons from the little Akkermansia muciniphila in hepatocellular carcinoma |
| title_full_unstemmed | Big lessons from the little Akkermansia muciniphila in hepatocellular carcinoma |
| title_short | Big lessons from the little Akkermansia muciniphila in hepatocellular carcinoma |
| title_sort | big lessons from the little akkermansia muciniphila in hepatocellular carcinoma |
| topic | hepatocellular carcinoma Akkermansia muciniphila immunotherapy traditional Chinese medicine intestinal flora |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1524563/full |
| work_keys_str_mv | AT yanguangyang biglessonsfromthelittleakkermansiamuciniphilainhepatocellularcarcinoma AT yanguangyang biglessonsfromthelittleakkermansiamuciniphilainhepatocellularcarcinoma AT xinlishi biglessonsfromthelittleakkermansiamuciniphilainhepatocellularcarcinoma AT xinlishi biglessonsfromthelittleakkermansiamuciniphilainhepatocellularcarcinoma |