Scalable and efficient electrochemical bromination of arenes with Faradaic efficiencies surpassing 90%
Abstract Developing cost-effective and environmentally friendly approaches to synthesize brominated chemicals, which are important intermediates for the synthesis of various useful molecules such as pharmaceuticals, surfactants, pesticides, and biologically active heterocyclic compounds, is of great...
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| Format: | Article |
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Nature Portfolio
2025-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-025-57329-0 |
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| author | Bing Zhang Wei Liu Zhu Liu Yuhou Pei Di Li Hongbin Yang Chuntian Qiu Yang Fan Yinghua Xu Jie Ding Lei Yu Bin Liu Chenliang Su |
| author_facet | Bing Zhang Wei Liu Zhu Liu Yuhou Pei Di Li Hongbin Yang Chuntian Qiu Yang Fan Yinghua Xu Jie Ding Lei Yu Bin Liu Chenliang Su |
| author_sort | Bing Zhang |
| collection | DOAJ |
| description | Abstract Developing cost-effective and environmentally friendly approaches to synthesize brominated chemicals, which are important intermediates for the synthesis of various useful molecules such as pharmaceuticals, surfactants, pesticides, and biologically active heterocyclic compounds, is of great significance. Herein, we present a highly efficient electrochemical bromine evolution reaction over vacancy rich Co3O4 using cheap NaBr as the bromine source for the synthesis of valuable brominated fine chemicals and pharmaceuticals under ambient conditions. The introduction of oxygen vacancy onto Co3O4 can greatly enhance the activity and selectivity of bromine evolution reaction by optimizing Br* intermediate adsorption and desorption, enabling bromination of a series of bioactive molecules and pharmaceuticals at high yields. |
| format | Article |
| id | doaj-art-4f384a556445450aa70c717df93871e2 |
| institution | DOAJ |
| issn | 2041-1723 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-4f384a556445450aa70c717df93871e22025-08-20T02:49:35ZengNature PortfolioNature Communications2041-17232025-03-0116111010.1038/s41467-025-57329-0Scalable and efficient electrochemical bromination of arenes with Faradaic efficiencies surpassing 90%Bing Zhang0Wei Liu1Zhu Liu2Yuhou Pei3Di Li4Hongbin Yang5Chuntian Qiu6Yang Fan7Yinghua Xu8Jie Ding9Lei Yu10Bin Liu11Chenliang Su12International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of Education, Institute of Microscale Optoelectronics, Shenzhen UniversityInternational Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of Education, Institute of Microscale Optoelectronics, Shenzhen UniversityZJU-Hangzhou Global Scientific and Technological Innovation Center, Zhejiang UniversityZJU-Hangzhou Global Scientific and Technological Innovation Center, Zhejiang UniversityZJU-Hangzhou Global Scientific and Technological Innovation Center, Zhejiang UniversityDepartment of Materials Science and Engineering, Department of Chemistry, Hong Kong Institute for Clean Energy (HKICE) & Center of Super Diamond and Advanced Films (COSDAF), City University of Hong KongInternational Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of Education, Institute of Microscale Optoelectronics, Shenzhen UniversityInternational Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of Education, Institute of Microscale Optoelectronics, Shenzhen UniversityCollege of Chemical Engineering, Zhejiang University of TechnologyDepartment of Materials Science and Engineering, Department of Chemistry, Hong Kong Institute for Clean Energy (HKICE) & Center of Super Diamond and Advanced Films (COSDAF), City University of Hong KongCollege of Chemistry and Chemical Engineering, Yangzhou UniversityDepartment of Materials Science and Engineering, Department of Chemistry, Hong Kong Institute for Clean Energy (HKICE) & Center of Super Diamond and Advanced Films (COSDAF), City University of Hong KongInternational Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of Education, Institute of Microscale Optoelectronics, Shenzhen UniversityAbstract Developing cost-effective and environmentally friendly approaches to synthesize brominated chemicals, which are important intermediates for the synthesis of various useful molecules such as pharmaceuticals, surfactants, pesticides, and biologically active heterocyclic compounds, is of great significance. Herein, we present a highly efficient electrochemical bromine evolution reaction over vacancy rich Co3O4 using cheap NaBr as the bromine source for the synthesis of valuable brominated fine chemicals and pharmaceuticals under ambient conditions. The introduction of oxygen vacancy onto Co3O4 can greatly enhance the activity and selectivity of bromine evolution reaction by optimizing Br* intermediate adsorption and desorption, enabling bromination of a series of bioactive molecules and pharmaceuticals at high yields.https://doi.org/10.1038/s41467-025-57329-0 |
| spellingShingle | Bing Zhang Wei Liu Zhu Liu Yuhou Pei Di Li Hongbin Yang Chuntian Qiu Yang Fan Yinghua Xu Jie Ding Lei Yu Bin Liu Chenliang Su Scalable and efficient electrochemical bromination of arenes with Faradaic efficiencies surpassing 90% Nature Communications |
| title | Scalable and efficient electrochemical bromination of arenes with Faradaic efficiencies surpassing 90% |
| title_full | Scalable and efficient electrochemical bromination of arenes with Faradaic efficiencies surpassing 90% |
| title_fullStr | Scalable and efficient electrochemical bromination of arenes with Faradaic efficiencies surpassing 90% |
| title_full_unstemmed | Scalable and efficient electrochemical bromination of arenes with Faradaic efficiencies surpassing 90% |
| title_short | Scalable and efficient electrochemical bromination of arenes with Faradaic efficiencies surpassing 90% |
| title_sort | scalable and efficient electrochemical bromination of arenes with faradaic efficiencies surpassing 90 |
| url | https://doi.org/10.1038/s41467-025-57329-0 |
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