Synthesis and Characterization of Theranostic Poly(HPMA)-c(RGDyK)-DOTA-Cu Copolymer Targeting Tumor Angiogenesis: Tumor Localization Visualized by Positron Emission Tomography
Poly(HPMA)-c(RGDyK)-DOTA- 64 Cu copolymers were synthesized and characterized for tumor localization in vivo as a theranostic scaffold for cancer imaging and anticancer drug delivery targeting tumor angiogenesis. Tumor localization of the poly(HPMA)-c(RGDyK)-DOTA- 64 Cu copolymers was visualized in...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2013-05-01
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| Series: | Molecular Imaging |
| Online Access: | https://doi.org/10.2310/7290.2012.00038 |
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| author | Jianchao Yuan Haiyuan Zhang Harpreet Kaur David Oupicky Fangyu Peng |
| author_facet | Jianchao Yuan Haiyuan Zhang Harpreet Kaur David Oupicky Fangyu Peng |
| author_sort | Jianchao Yuan |
| collection | DOAJ |
| description | Poly(HPMA)-c(RGDyK)-DOTA- 64 Cu copolymers were synthesized and characterized for tumor localization in vivo as a theranostic scaffold for cancer imaging and anticancer drug delivery targeting tumor angiogenesis. Tumor localization of the poly(HPMA)-c(RGDyK)-DOTA- 64 Cu copolymers was visualized in mice bearing human prostate cancer xenografts by positron emission tomography (PET) using a microPET scanner. PET quantitative analysis demonstrated that tumor 64 Cu radioactivity (2.75 ± 0.34 %ID/g) in tumor-bearing mice 3 hours following intravenous injection of the poly(HPMA)-c(RGDyK)-DOTA- 64 Cu copolymers was significantly higher than the tumor 64 Cu radioactivity (1.29 ± 0.26 %ID/g) in tumor-bearing mice injected with the nontargeted poly(HPMA)-DOTA- 64 Cu copolymers ( p = .004). The poly(HPMA)-c(RGDyK)-DOTA- 64 Cu copolymers hold potential as a theranostic scaffold for cancer imaging and radiochemotherapy of prostate cancer targeting tumor angiogenesis by noninvasive tracking with PET. |
| format | Article |
| id | doaj-art-4f376e0f0b8f475781e58cb847ee57fc |
| institution | DOAJ |
| issn | 1536-0121 |
| language | English |
| publishDate | 2013-05-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Molecular Imaging |
| spelling | doaj-art-4f376e0f0b8f475781e58cb847ee57fc2025-08-20T02:43:14ZengSAGE PublishingMolecular Imaging1536-01212013-05-011210.2310/7290.2012.0003810.2310_7290.2012.00038Synthesis and Characterization of Theranostic Poly(HPMA)-c(RGDyK)-DOTA-Cu Copolymer Targeting Tumor Angiogenesis: Tumor Localization Visualized by Positron Emission TomographyJianchao YuanHaiyuan ZhangHarpreet KaurDavid OupickyFangyu PengPoly(HPMA)-c(RGDyK)-DOTA- 64 Cu copolymers were synthesized and characterized for tumor localization in vivo as a theranostic scaffold for cancer imaging and anticancer drug delivery targeting tumor angiogenesis. Tumor localization of the poly(HPMA)-c(RGDyK)-DOTA- 64 Cu copolymers was visualized in mice bearing human prostate cancer xenografts by positron emission tomography (PET) using a microPET scanner. PET quantitative analysis demonstrated that tumor 64 Cu radioactivity (2.75 ± 0.34 %ID/g) in tumor-bearing mice 3 hours following intravenous injection of the poly(HPMA)-c(RGDyK)-DOTA- 64 Cu copolymers was significantly higher than the tumor 64 Cu radioactivity (1.29 ± 0.26 %ID/g) in tumor-bearing mice injected with the nontargeted poly(HPMA)-DOTA- 64 Cu copolymers ( p = .004). The poly(HPMA)-c(RGDyK)-DOTA- 64 Cu copolymers hold potential as a theranostic scaffold for cancer imaging and radiochemotherapy of prostate cancer targeting tumor angiogenesis by noninvasive tracking with PET.https://doi.org/10.2310/7290.2012.00038 |
| spellingShingle | Jianchao Yuan Haiyuan Zhang Harpreet Kaur David Oupicky Fangyu Peng Synthesis and Characterization of Theranostic Poly(HPMA)-c(RGDyK)-DOTA-Cu Copolymer Targeting Tumor Angiogenesis: Tumor Localization Visualized by Positron Emission Tomography Molecular Imaging |
| title | Synthesis and Characterization of Theranostic Poly(HPMA)-c(RGDyK)-DOTA-Cu Copolymer Targeting Tumor Angiogenesis: Tumor Localization Visualized by Positron Emission Tomography |
| title_full | Synthesis and Characterization of Theranostic Poly(HPMA)-c(RGDyK)-DOTA-Cu Copolymer Targeting Tumor Angiogenesis: Tumor Localization Visualized by Positron Emission Tomography |
| title_fullStr | Synthesis and Characterization of Theranostic Poly(HPMA)-c(RGDyK)-DOTA-Cu Copolymer Targeting Tumor Angiogenesis: Tumor Localization Visualized by Positron Emission Tomography |
| title_full_unstemmed | Synthesis and Characterization of Theranostic Poly(HPMA)-c(RGDyK)-DOTA-Cu Copolymer Targeting Tumor Angiogenesis: Tumor Localization Visualized by Positron Emission Tomography |
| title_short | Synthesis and Characterization of Theranostic Poly(HPMA)-c(RGDyK)-DOTA-Cu Copolymer Targeting Tumor Angiogenesis: Tumor Localization Visualized by Positron Emission Tomography |
| title_sort | synthesis and characterization of theranostic poly hpma c rgdyk dota cu copolymer targeting tumor angiogenesis tumor localization visualized by positron emission tomography |
| url | https://doi.org/10.2310/7290.2012.00038 |
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