Mechanosensitive channel engineering: A study on the mixing and matching of YnaI and MscS sensor paddles and pores

Abstract Osmotically varying environments are challenging for bacterial cells. Sudden drops in osmolytes cause an increased membrane tension and rupture the cells in the absence of protective mechanisms. One family of protective proteins are mechanosensitive channels of small conductance that open i...

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Bibliographic Details
Main Authors: Vanessa J. Flegler, Akiko Rasmussen, Rainer Hedrich, Tim Rasmussen, Bettina Böttcher
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-63253-0
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