Relationship between patent ductus arteriosus and platelet indices in newborn: a systematic review and meta-analysis
BackgroundThe role of platelet indices in the early hours of life and their potential association with patent ductus arteriosus (PDA) have been subjects of investigation in recent studies. This study aimed to investigate the relationship between PAD and platelet indices in newborn.MethodsA systemati...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-03-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2025.1455183/full |
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| author | Yanbing An Gaowa Arigong Wuyun Zhao Rina Su Xiaoyun Wang |
| author_facet | Yanbing An Gaowa Arigong Wuyun Zhao Rina Su Xiaoyun Wang |
| author_sort | Yanbing An |
| collection | DOAJ |
| description | BackgroundThe role of platelet indices in the early hours of life and their potential association with patent ductus arteriosus (PDA) have been subjects of investigation in recent studies. This study aimed to investigate the relationship between PAD and platelet indices in newborn.MethodsA systematic review and meta-analysis and were preformed based on Chinese databases CNKI and Wanfang database, as well as the international databases PubMed, Web of Science, Cochrane Library, and Embase from their inception to January 31, 2024.ResultsThis study included 32 literatures, with 20 of English and 12 of Chinese ones. The meta regression analysis showed that neonates with PDA tend to exhibit lower platelet count (PLT) and plateletcrit (PCT), as well as higher platelet large cell ratio (P-LCR) (all P < 0.05), while platelet mass, platelet distribution width (PDW), and mean platelet volume (MPV) remain comparable (all P > 0.05).ConclusionPDA neonates might have decreased PLT and PCT, while increased P-LCR. These dynamic shifts in platelet indices provide fresh insights into the pathophysiology of PDA and have potential to serve as important indicators for early identification, disease assessment, and personalized treatment decisions in clinical practice. |
| format | Article |
| id | doaj-art-4f2f73b863a646faa0d1f64cb8d3ec6d |
| institution | DOAJ |
| issn | 2296-2360 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj-art-4f2f73b863a646faa0d1f64cb8d3ec6d2025-08-20T02:41:20ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602025-03-011310.3389/fped.2025.14551831455183Relationship between patent ductus arteriosus and platelet indices in newborn: a systematic review and meta-analysisYanbing An0Gaowa Arigong1Wuyun Zhao2Rina Su3Xiaoyun Wang4Department of Neonatology, Inner Mongolia Maternal and Child Health Hospital, Hohhot, ChinaDepartment of Neonatology, Inner Mongolia Maternal and Child Health Hospital, Hohhot, ChinaDepartment of Nursing, Inner Mongolia Maternal and Child Health Hospital, Hohhot, ChinaDepartment of Nursing, Inner Mongolia Maternal and Child Health Hospital, Hohhot, ChinaDepartment of Nursing, Inner Mongolia Maternal and Child Health Hospital, Hohhot, ChinaBackgroundThe role of platelet indices in the early hours of life and their potential association with patent ductus arteriosus (PDA) have been subjects of investigation in recent studies. This study aimed to investigate the relationship between PAD and platelet indices in newborn.MethodsA systematic review and meta-analysis and were preformed based on Chinese databases CNKI and Wanfang database, as well as the international databases PubMed, Web of Science, Cochrane Library, and Embase from their inception to January 31, 2024.ResultsThis study included 32 literatures, with 20 of English and 12 of Chinese ones. The meta regression analysis showed that neonates with PDA tend to exhibit lower platelet count (PLT) and plateletcrit (PCT), as well as higher platelet large cell ratio (P-LCR) (all P < 0.05), while platelet mass, platelet distribution width (PDW), and mean platelet volume (MPV) remain comparable (all P > 0.05).ConclusionPDA neonates might have decreased PLT and PCT, while increased P-LCR. These dynamic shifts in platelet indices provide fresh insights into the pathophysiology of PDA and have potential to serve as important indicators for early identification, disease assessment, and personalized treatment decisions in clinical practice.https://www.frontiersin.org/articles/10.3389/fped.2025.1455183/fullnewbornpatent ductus arteriosusplateletrelationshipmeta-analysis |
| spellingShingle | Yanbing An Gaowa Arigong Wuyun Zhao Rina Su Xiaoyun Wang Relationship between patent ductus arteriosus and platelet indices in newborn: a systematic review and meta-analysis Frontiers in Pediatrics newborn patent ductus arteriosus platelet relationship meta-analysis |
| title | Relationship between patent ductus arteriosus and platelet indices in newborn: a systematic review and meta-analysis |
| title_full | Relationship between patent ductus arteriosus and platelet indices in newborn: a systematic review and meta-analysis |
| title_fullStr | Relationship between patent ductus arteriosus and platelet indices in newborn: a systematic review and meta-analysis |
| title_full_unstemmed | Relationship between patent ductus arteriosus and platelet indices in newborn: a systematic review and meta-analysis |
| title_short | Relationship between patent ductus arteriosus and platelet indices in newborn: a systematic review and meta-analysis |
| title_sort | relationship between patent ductus arteriosus and platelet indices in newborn a systematic review and meta analysis |
| topic | newborn patent ductus arteriosus platelet relationship meta-analysis |
| url | https://www.frontiersin.org/articles/10.3389/fped.2025.1455183/full |
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