Prevalence and impact of molecular variation in the three-prime repair exonuclease 1 TREX1 and its implications for oncology
Abstract Background The three-prime repair exonuclease 1, TREX1, degrades cytosolic DNA to prevent aberrant immune activation. Its inactivation results in DNA accumulation in the cytosol and induction of the cGAS-STING DNA sensing pathway, interferon signaling, and inflammation. Germline pathogenic...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-06-01
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| Series: | Human Genomics |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40246-025-00785-y |
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