A POSSIBLE RELATIONSHIP BETWEEN SERUM HOMOCYSTEINE LEVEL AND IgA NEPHROPATHY IN CHILDREN
Objective: The evidences from experimental and epidemiological studies suggests that elevated serum homocysteine levels may lead to renal injury and may be a significant risk factor for the development of chronic kidney disease. The aim of this study was to investigate a possible relationship betwee...
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Istanbul University Press
2021-09-01
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| Series: | İstanbul Tıp Fakültesi Dergisi |
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| Online Access: | https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/9080E8B82A7A4857B80B67C9BC3175C5 |
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| author | Cemile Pehlivanoğlu Zeynep Nagehan Yürük Yıldırım Alev Yılmaz Asuman Gedikbaşı Nurinisa Karagöz Nurver Akıncı Aysel Kıyak Gül Özçelik Mesude Yasemin Özlük Işın Kılıçaslan Ayşe Ayşim Özağarı Bağdagül Yavaş Aksu Sevinç Emre |
| author_facet | Cemile Pehlivanoğlu Zeynep Nagehan Yürük Yıldırım Alev Yılmaz Asuman Gedikbaşı Nurinisa Karagöz Nurver Akıncı Aysel Kıyak Gül Özçelik Mesude Yasemin Özlük Işın Kılıçaslan Ayşe Ayşim Özağarı Bağdagül Yavaş Aksu Sevinç Emre |
| author_sort | Cemile Pehlivanoğlu |
| collection | DOAJ |
| description | Objective: The evidences from experimental and epidemiological studies suggests that elevated serum homocysteine levels may lead to renal injury and may be a significant risk factor for the development of chronic kidney disease. The aim of this study was to investigate a possible relationship between serum homocysteine level and crescent formation in children with IgA nephropathy and Henoch-Schonlein purpura nephritis. Material and Methods: A total of 31 patients diagnosed as biopsy proven IgA nephropathy and Henoch-Schonlein purpura nephritis and idiopathic crescentic glomerulonephritis in three Pediatric Nephrology centers within the last five years and 25 healthy controls were enrolled in the study. Results: Homocysteine levels of patients were higher than the upper limit of normal value and also higher than the controls (p=0.0001). There was no significant difference between the patients with or without crescent formation regarding homocysteine levels (p>0.05). Presence or severity of proteinuria was not related to homocysteine levels (p>0.05). Conclusion: Serum homocysteine levels are elevated in patients with IgA nephropathy and Henoch-Schonlein purpura nephritis.Our results suggest that elevated serum homocysteine levels may be related to segmental glomerulosclerosis in these patient groups. |
| format | Article |
| id | doaj-art-4f2d621e206a450c973647c677224dc4 |
| institution | Kabale University |
| issn | 1305-6441 |
| language | English |
| publishDate | 2021-09-01 |
| publisher | Istanbul University Press |
| record_format | Article |
| series | İstanbul Tıp Fakültesi Dergisi |
| spelling | doaj-art-4f2d621e206a450c973647c677224dc42025-08-20T03:52:47ZengIstanbul University Pressİstanbul Tıp Fakültesi Dergisi1305-64412021-09-0184456857310.26650/IUITFD.2021.847530123456A POSSIBLE RELATIONSHIP BETWEEN SERUM HOMOCYSTEINE LEVEL AND IgA NEPHROPATHY IN CHILDRENCemile Pehlivanoğlu0https://orcid.org/0000-0002-6949-8922Zeynep Nagehan Yürük Yıldırım1https://orcid.org/0000-0003-2891-2231Alev Yılmaz2https://orcid.org/0000-0003-1743-1491Asuman Gedikbaşı3https://orcid.org/0000-0001-7121-6077Nurinisa Karagöz4https://orcid.org/0000-0002-4575-4100Nurver Akıncı5https://orcid.org/0000-0002-8355-4214Aysel Kıyak6https://orcid.org/0000-0003-1073-000XGül Özçelik7https://orcid.org/0000-0001-9394-2977Mesude Yasemin Özlük8https://orcid.org/0000-0002-7191-0488Işın Kılıçaslan9https://orcid.org/0000-0002-4206-9941Ayşe Ayşim Özağarı10https://orcid.org/0000-0003-2343-1236Bağdagül Yavaş Aksu11https://orcid.org/0000-0003-3274-8024Sevinç Emre12https://orcid.org/0000-0002-9708-9480İstanbul Üniversitesi, İstanbul, Türkiyeİstanbul Üniversitesi, İstanbul, Türkiyeİstanbul Üniversitesi, İstanbul, Türkiyeİstanbul Üniversitesi, İstanbul, Türkiyeİstanbul Üniversitesi, İstanbul, TürkiyeSağlık Bakanlığı, Ankara, TurkiyeSağlık Bilimleri Üniversitesi, Istanbul, TurkiyeSağlık Bilimleri Üniversitesi, Istanbul, Turkiyeİstanbul Üniversitesi, İstanbul, Türkiyeİstanbul Üniversitesi, İstanbul, TürkiyeSağlık Bilimleri Üniversitesi, Istanbul, Turkiyeİstanbul Üniversitesi, İstanbul, Türkiyeİstanbul Üniversitesi, İstanbul, TürkiyeObjective: The evidences from experimental and epidemiological studies suggests that elevated serum homocysteine levels may lead to renal injury and may be a significant risk factor for the development of chronic kidney disease. The aim of this study was to investigate a possible relationship between serum homocysteine level and crescent formation in children with IgA nephropathy and Henoch-Schonlein purpura nephritis. Material and Methods: A total of 31 patients diagnosed as biopsy proven IgA nephropathy and Henoch-Schonlein purpura nephritis and idiopathic crescentic glomerulonephritis in three Pediatric Nephrology centers within the last five years and 25 healthy controls were enrolled in the study. Results: Homocysteine levels of patients were higher than the upper limit of normal value and also higher than the controls (p=0.0001). There was no significant difference between the patients with or without crescent formation regarding homocysteine levels (p>0.05). Presence or severity of proteinuria was not related to homocysteine levels (p>0.05). Conclusion: Serum homocysteine levels are elevated in patients with IgA nephropathy and Henoch-Schonlein purpura nephritis.Our results suggest that elevated serum homocysteine levels may be related to segmental glomerulosclerosis in these patient groups.https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/9080E8B82A7A4857B80B67C9BC3175C5iga nephropathyhomocysteinecrescent |
| spellingShingle | Cemile Pehlivanoğlu Zeynep Nagehan Yürük Yıldırım Alev Yılmaz Asuman Gedikbaşı Nurinisa Karagöz Nurver Akıncı Aysel Kıyak Gül Özçelik Mesude Yasemin Özlük Işın Kılıçaslan Ayşe Ayşim Özağarı Bağdagül Yavaş Aksu Sevinç Emre A POSSIBLE RELATIONSHIP BETWEEN SERUM HOMOCYSTEINE LEVEL AND IgA NEPHROPATHY IN CHILDREN İstanbul Tıp Fakültesi Dergisi iga nephropathy homocysteine crescent |
| title | A POSSIBLE RELATIONSHIP BETWEEN SERUM HOMOCYSTEINE LEVEL AND IgA NEPHROPATHY IN CHILDREN |
| title_full | A POSSIBLE RELATIONSHIP BETWEEN SERUM HOMOCYSTEINE LEVEL AND IgA NEPHROPATHY IN CHILDREN |
| title_fullStr | A POSSIBLE RELATIONSHIP BETWEEN SERUM HOMOCYSTEINE LEVEL AND IgA NEPHROPATHY IN CHILDREN |
| title_full_unstemmed | A POSSIBLE RELATIONSHIP BETWEEN SERUM HOMOCYSTEINE LEVEL AND IgA NEPHROPATHY IN CHILDREN |
| title_short | A POSSIBLE RELATIONSHIP BETWEEN SERUM HOMOCYSTEINE LEVEL AND IgA NEPHROPATHY IN CHILDREN |
| title_sort | possible relationship between serum homocysteine level and iga nephropathy in children |
| topic | iga nephropathy homocysteine crescent |
| url | https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/9080E8B82A7A4857B80B67C9BC3175C5 |
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